Circadian rhythm and melatonin

The paper develops a data-driven model of the circadian clock in Neurospora crassa using luciferase reporter data to estimate parameters and reveal the role of FRQ maturation in circadian rhythms.

This study analyzes the circadian nuclear and cytoplasmic transcriptomes in mouse liver to understand temporal regulation of RNA processing and stability.

This study examines how fentanyl affects sleep architecture and how the circadian factor NPAS2 influences these changes during withdrawal in male mice.

The paper analyzes a baboon diurnal transcriptome atlas to show that 53.4% of genes are rhythmically expressed and that circadian gene networks exhibit daytime and nighttime modes with distinct biological functions.

The paper introduces the PAICE suite to detect circadian oscillations in RNA and protein data, revealing post-transcriptional regulation and spliceosome timing in mouse macrophages.

The paper investigates whether light affects human prefrontal cortex activity through a pathway similar to that in animals, finding luminance-dependent signals in multiple brain regions.

This study uses microendoscopic Ca2+ imaging to show that SCN neurons in vivo exhibit both fast Ca2+ spikes and slow baseline changes, revealing diverse activity patterns within a coordinated circadian network.

The paper analyzes synaptic connectivity in Drosophila lateral neuron clock cells to identify distinct connectomic types and their roles in circadian timekeeping.

This paper identifies the role of PER phosphodegron residues in temperature compensation of the Drosophila circadian clock through genetic and biochemical experiments.

The paper updates a circadian clock model for Arabidopsis to predict phenotype effects of gene mis-regulation using metabolic and physiological data.

This study shows that overexpression of HSP40 in pacemaker neurons rescues circadian dysfunction in a Drosophila Huntington's Disease model by restoring circadian proteins and reducing Huntingtin inclusion load.

The paper identifies two light sensors in Platynereis dumerilii that distinguish moonlight from sunlight to adjust a circadian clock to moon phase.

This study investigates how PDF receptor signaling is terminated in Drosophila, showing that phosphorylation sites in its C-terminal tail regulate behavioral rhythms and that specific mutations alter these rhythms in a day-length-dependent manner.

The paper experimentally demonstrates period doubling and quadrupling in a synthetic genetic oscillator under external perturbations.

The paper investigates the association between Clock gene polymorphism and annual cycle timing in stonechats across different populations, finding population-specific links between repeat length and timing.

This study shows that IGF-I regulates circadian feeding behavior and metabolism via hypothalamic orexin neurons in mice.

The paper shows that circadian pacemaker neurons in Drosophila exhibit co-phasic rhythms in basal calcium levels and fast calcium fluctuations, driven by IP3R and T-type channels respectively.

This study identifies M1 ipRGCs as the primary driver of photoaversion in neonatal mice by showing their unique photosensitivity and behavioral relevance.

The paper shows that a natural allele of the timeless gene allows Drosophila to synchronize circadian clocks to temperature cycles in constant light.

The paper investigates molecular rhythm alterations in the prefrontal cortex and nucleus accumbens of individuals with opioid use disorder, finding distinct rhythmic transcript patterns and associations with sleep and neurotransmitter systems.

This study directly measures the light response of the human SCN and finds that light suppresses SCN activity across multiple wavelengths, suggesting a need to revise light exposure strategies.

The paper quantifies circadian interactions and protein abundance to reveal mechanisms maintaining the circadian clock's operational stability.

The paper shows that chloride levels in Drosophila pacemaker neurons regulate circadian rhythms via a WNK-Fray signaling cascade and potassium channel activity.

This study shows that KCC and NKCC cotransporters regulate GABA responses and locomotor activity in Drosophila under constant light and long days through a feedback loop involving Wnk and Fray kinases.

The paper develops a unified model, dCiRC, to predict circadian entrainment phase by integrating parametric and non-parametric aspects of circadian clock responses to light.

This study identifies Clock and cycle as neuroprotective circadian regulators in Drosophila photoreceptors that prevent retinal degeneration and oxidative stress during aging.

This study shows that circadian rhythm disruption in mice leads to visual dysfunction, including retinal thinning and reduced visual acuity, with behavior-dependent effects on retinal proteins.

This study shows that manipulating SCN neural activity in mice affects anxiety-like behavior but not depressive-like behavior, with dampened activity rhythms correlating with increased anxiety.

The paper shows that magnetic fields and lithium affect circadian rhythms through radical pair mechanisms in cryptochromes, reproducing experimental results and predicting isotope-dependent lithium effects.

The paper develops a spatio-temporal model to analyze circadian gene expression dynamics in single cells, revealing spatial and temporal differences in oscillation robustness and regulatory profiles in mouse SCN tissue.