Hydrogels: synthesis, properties, applications

OcuPair, a novel photo-crosslinkable dendrimer-hyaluronic acid hydrogel bandage/bioadhesive for corneal injuries and temporary corneal repair

The paper develops OcuPair, a hydrogel bandage for corneal injuries that seals wounds and maintains eye stability, showing effectiveness in ex vivo and animal models.

Crosslinker-free in situ hydrogel induces self-aggregation of human dental pulp stem cells with enhanced antibacterial activity

This paper develops an injectable hydrogel with antibacterial properties for tissue engineering applications, showing good biocompatibility and ability to form 3D cell aggregates.

Tunable bicontinuous macroporous cell culture scaffolds via kinetically controlled phase separation

This paper develops tunable macroporous hydrogels via phase separation for cell culture, showing improved cell spreading and migration in porous systems.

Enabling Hydrogel Coating on Silicone Breast Implants with Poly(Vinyl Acetate) Primer Layer

This study introduces a PVAc primer layer to improve hydrogel adhesion on silicone implants, validated with two commercial hydrogels.

Dynamic Hydrogel Crosslink Strength Controls Yielding Characteristics and Cell Viability During Injection

This study investigates how dynamic hydrogel crosslink strength affects yielding behavior and cell viability during injection, finding that slower yielding transitions enhance cell protection.

A thiol--ene click-based strategy to customize injectable polymer--nanoparticle hydrogel properties for therapeutic delivery

This paper develops a thiol-ene click chemistry strategy to modify HPMC for tunable PNP hydrogel properties, enabling controlled drug and cell delivery.

Multi-reactive hydrogel nanovials for temporal control of secretion capture from antibody-secreting cells

This paper introduces multi-reactive hydrogel nanovials that enable temporal control of secretion capture from antibody-secreting cells, achieving high-purity isolation of antigen-specific hybridomas.

Biocompatible Composite Hydrogel with On-Demand Swelling-Shrinking Properties for 4D Bioprinting

This paper develops a high-swelling composite hydrogel, SwellMA, for 4D bioprinting, showing superior swelling capacity and on-demand swelling-shrinking behavior.

A screening setup to streamline in vitro Engineered Living Material cultures with the host

The paper develops a 96-well plate-based screening method to evaluate ELM growth and host compatibility in vitro.

Engineering tissue-mimetic hydrogels with continuous viscoelastic gradient for programmed cell migration

This paper develops hydrogels with continuous viscoelastic gradients to study cell migration influenced by local viscosity and elasticity rather than stiffness.

Anti-fibrotic Effects of Atorvastatin Delivered via Keratin-based Hydrogels

This paper investigates the anti-fibrotic effects of atorvastatin-loaded keratin hydrogels by evaluating their drug release, cytotoxicity, and impact on fibroblast proliferation.

Measurement of covalent bond formation in light-curing hydrogels predicts physical stability under flow

The paper measures covalent bond formation in light-curing hydrogels using NMR to predict their stability under fluid flow.

Design of PEG-based hydrogels as soft ionic conductors

This study designs PEG-based hydrogels with ionic conductivity by optimizing salt concentration, water content, and network structure to achieve desired mechanical and conductive properties.

Spatiotemporally Programmed Release of Aptamer Tethered Dual Angiogenic Growth Factors

This paper develops a biomaterial platform that spatially controls the release of multiple angiogenic growth factors in a time-controlled manner.

Intervening to preserve function in ischemic cardiomyopathy with a porous hydrogel and extracellular matrix composite in a rat myocardial infarction model

This study evaluates a hydrogel with porosity and extracellular matrix digest in a rat myocardial infarction model, showing improved cardiac function and neovascularization compared to other hydrogels and PBS.

Highly porous granular hydrogels reinforced by electrospun hydrogel fibers for long-term stability

This study develops a highly porous granular hydrogel scaffold reinforced with hydrogel fibers to maintain stability and support cell growth.

Crosslinker Architectures Impact Viscoelasticity in Dynamic Covalent Hydrogels

This study investigates how different crosslinker architectures affect the viscoelastic properties of dynamic covalent hydrogels, showing that side-chain and telechelic crosslinkers lead to distinct mechanical behaviors.

Probing the effects of polysaccharide hydrogel composition on the viability and pro-angiogenic function of human adipose-derived stromal cells

This study evaluates how different polysaccharide hydrogel compositions affect the viability and pro-angiogenic function of human adipose-derived stromal cells in vitro and in vivo.

Programmable soft DNA hydrogels stimulate cellular endocytic pathways and proliferation

This paper develops DNA-based hydrogels that stimulate cellular endocytic pathways and proliferation by mimicking in vivo environments through programmable supramolecular structures.

Optimising the viscoelastic properties of hyaluronic acid hydrogels through colloidal particle interactions: a response surface methodology approach

This study optimizes hyaluronic acid hydrogel viscoelasticity using colloidal particle interactions and response surface methodology, finding mixed nanoparticles yield the highest complex viscosity.

IGF-1 Peptide Mimetic-functionalized Hydrogels Enhance MSC Survival and Immunomodulatory Activity

This study shows that IGF-1 peptide mimetics functionalized on hydrogels enhance MSC survival and reduce inflammation in human intervertebral disc cells.

Development of self-healing hydrogels to support choroidal endothelial cell transplantation for the treatment of early age related macular degeneration

This paper develops self-healing hydrogels to support choroidal endothelial cell transplantation in a rat model, showing improved cell retention compared to cell suspensions.

Engineered 3D Hydrogel Matrices to Modulate Trophoblast Stem Cell-Derived Placental Organoid Phenotype

This study uses engineered 3D hydrogels to generate placental organoids and shows they support trophoblast viability and differentiation comparable to Matrigel.

Mechanical characterization of soft biomaterials: which time and spatial scale to choose?

This study compares mechanical testing techniques for soft gels, highlighting the importance of time and spatial scales in characterizing biomaterials.

PenTag, a Versatile Platform for Synthesizing Protein-Polymer Biohybrid Materials

PenTag enables specific, covalent conjugation of proteins to ligands for biohybrid material synthesis, demonstrating applications in hydrogels and computational systems.

Understanding the dynamics of complex in-situ enzyme-catalyzed reactions undergoing mechanical stress

The paper develops a computational method to study how mechanical stress affects enzyme-catalyzed reactions with complex kinetics.

A photoreceptor-based hydrogel with red light-responsive reversible sol-gel transition as transient cellular matrix

This paper develops a red light-responsive hydrogel that allows reversible control of stiffness for cell positioning in microfluidic systems.

Engineering a material-genetic interface as safety switch for embedded therapeutic cells

The paper develops a material-genetic interface as a safety switch for engineered cells in hydrogels to control therapeutic agent production based on the presence of the embedding material.

Tough Hydrogel-Based Biocontainment of Engineered Organisms for Continuous, Self-Powered Sensing and Computation

This paper develops a hydrogel-based containment system for genetically modified microorganisms to enable safe, retrievable, and functional biosensing applications.

Foreign body responses in central nervous system mimic natural wound responses and alter biomaterial functions

This study investigates CNS foreign body responses (FBRs) and shows they mimic wound responses, altering biomaterial functions based on interface properties.