Hydrogels: synthesis, properties, applications

Genetic Manipulation of Mammalian Cells in Microphysiological Hydrogels

This study demonstrates the use of GelMA hydrogels for 3D cell culture with in situ genetic manipulation and spatially controlled gene expression.

Controlled release of microorganisms from engineered living materials

This paper demonstrates a method to release probiotics from hydrogels using mechanical fracture, enabling sustained and controllable release of metabolically active microbes.

A Light Sensitive Hyaluronic Acid-based Hydrogel for 3D Culturing, Differentiation, and Harvesting of Mesenchymal Stromal Cells

This paper introduces a light-sensitive hyaluronic acid hydrogel for 3D cell culturing, differentiation, and harvesting of mesenchymal stromal cells, showing it can modulate cell behavior through light exposure.

Hydrogel-embedded precision-cut lung slices support ex vivo culture of in vivo-induced premalignant lung lesions

This study shows that hydrogel-embedded precision-cut lung slices can maintain premalignant lung lesions for six weeks and respond to a cancer prevention agent.

Development and Characterization of 3D Printable Caprine derived dECM/DAS Crosslinked Hydrogels for Tissue Engineering Applications

This study develops a tunable hydrogel combining caprine-derived dECM and DAS for tissue engineering, showing improved mechanical properties and hemocompatibility.

Engineering Controlled Microporosity in Liquid-Core Soft Compartments via Compositional Tuning of Aqueous Immiscible Systems for Facilitated Cell Migration

This paper develops liquid-core soft compartments with tunable microporosity to enhance cell migration for tissue engineering.

Reinforced polymer-nanoparticle hydrogels for subcutaneous and sustained delivery of trastuzumab

This paper develops a hydrogel platform for subcutaneous delivery of trastuzumab, achieving sustained release over 3 days in vitro and in vivo.

An injectable granular hydrogel stabilized by electrostatic interactions between hyaluronic acid-based microparticles and soluble gelatin exhibits poroelasticity and strain-stiffening

This paper develops an electrostatically stabilized granular hydrogel with poroelasticity and strain-stiffening for biomedical applications like 3D bioprinting and wound healing.

Engineering Sustained-Release Broadly Neutralizing Antibody Formulations

This paper develops a hydrogel depot system to prolong the release of broadly neutralizing antibodies, showing improved pharmacokinetics and reduced immune cell-mediated release through co-formulation with anti-inflammatory agents.

Genetically Programmable Adhesive Protein Hydrogels for Sealing Perforating Corneal Trauma

This paper develops a genetically programmable protein hydrogel for sealing corneal perforations in animal models, showing effective adhesion and biocompatibility.

NIR Phosphorescent Oxygen Sensors in Natural Hydrogel Matrices

This study evaluates the impact of sterilization and treatment methods on oxygen-sensitive microparticles embedded in natural hydrogel matrices, finding E-beam sterilization most reliable for alginate and BSA matrices.

Applying computational protein design to engineer affibodies for affinity-controlled delivery of vascular endothelial growth factor and platelet-derived growth factor

This paper engineers affibodies with tunable affinities for VEGF and PDGF using computational design and yeast display to improve controlled protein release from hydrogels.

Expansion of functional human salivary acinar cell spheroids with reversible thermo-ionically crosslinked 3D hydrogels

This study evaluates AG-based hydrogels for expanding human salivary gland spheroids, finding AGHA gels support larger, viable, and functionally active spheroids with sustained protein expression.

Advancing Therapeutic Solutions: Poloxamer-based Thermosensitive Injectable Hydrogels containing a Self-assembling Peptide for In situ Gelation in an Osteoarthritis Murine Model

This paper develops a poloxamer-based hydrogel with a self-assembling peptide for rapid in situ gelation and sustained drug delivery in an osteoarthritis mouse model.

An injectable chitosan hydrogel localizes and tunably releases immunotherapeutics intratumorally eliminating both treated and abscopal murine triple negative breast tumors

This paper demonstrates that XCSgel, an injectable hydrogel, can localize and release immunotherapeutics to eliminate primary and abscopal murine triple-negative breast tumors with a single injection.

Hydrogels with Independently Controlled Adhesion Ligand Mobility and Viscoelasticity Increase Cell Adhesion and Spreading

This paper designs a hydrogel platform with independently controllable adhesion ligand mobility and viscoelasticity, showing that dual presentation of RGD ligands on both covalent and dynamic networks maximizes endothelial cell adhesion and spreading.

Focused Ultrasound Crosslinkable Granular Hydrogels

This paper develops a FUS-responsive granular hydrogel system that stabilizes through crosslinking and porosity control, showing potential for minimally invasive tissue regeneration.

Evaluation of adipose-derived stromal cell infused modified-hyaluronic acid scaffolds for post cancer breast reconstruction

This study evaluates modified hyaluronic acid scaffolds infused with adipose-derived stromal cells for post-cancer breast reconstruction, showing favorable biomechanical properties and tissue integration in vitro and in vivo.

Photocrosslinkable and biodegradable hydrogels for the controlled delivery of exosomes

This study develops photocrosslinkable, biodegradable alginate hydrogels for controlled exosome delivery, showing that degradation rates influence exosome release kinetics.

Injectable adhesive hydrogel-drug complexes synchronize the release of chemoimmunotherapy to treat brain tumors in mice

This study develops injectable hydrogel-drug complexes that synchronize chemoimmunotherapy release to treat brain tumors in mice, achieving long-term survival and protection from rechallenge.

A Mechanically Resilient Soft Hydrogel Improves Drug Delivery for Treating Post-Traumatic Osteoarthritis in Physically Active Joints

This paper develops a mechanically resilient hydrogel for drug delivery in physically active joints, showing sustained release and reduced cartilage degeneration in a mouse model of post-traumatic osteoarthritis.

Promoting Polarization and Differentiation of Primary Human Salivary Gland Stem/Progenitor Cells in Protease-Degradable Hydrogels via ROCK Inhibition

Heparin flexibility within the extracellular matrix determines the bioactivity of bound vascular endothelial growth factor

This study shows that heparin flexibility in the extracellular matrix affects VEGF mobility and bioactivity by influencing its interaction with VEGF receptor 2.

GelMA as scaffold material for epithelial cells to emulate the small intestinal microenvironment.

This study evaluates GelMA as a scaffold material for intestinal epithelial cells, finding it suitable for permeability, mechanical strength, and biocompatibility.

Fabrication & characterization of hyaluronic acid/eucalyptus hydrogels loaded with PLGA nanoparticles with methotrexate as an Injectable therapy for rheumatoid arthritis

This study develops hyaluronic acid/eucalyptus hydrogels loaded with PLGA nanoparticles containing methotrexate as an injectable therapy for rheumatoid arthritis, showing improved stability and biocompatibility.

Clustered VEGF Nanoparticles in Microporous Annealed Particle (MAP) Hydrogel Accelerates Functional Recovery and Brain Tissue Repair after Stroke

This study develops VEGF-coated heparin nanoparticles in MAP hydrogels to promote brain repair after stroke, showing improved tissue formation and functional recovery without free heparin.

Lithographic structuring of thermoresponsive hydrogel on a micron scale

This paper develops a method to create thermoresponsive hydrogel microstructures that dynamically expand and contract in response to temperature changes, mimicking extracellular environment dynamics.

PEARL: Protein Eluting Alginate with Recombinant Lactobacilli

This study develops PEARL, an engineered living material using encapsulated recombinant lactobacilli in alginate beads for controlled protein release over 14 days.

Tunable porosity in a hydrogel with extreme vibration damping properties

This paper develops hydrogels with tunable porosity and extreme vibration damping properties using dialysis casting, showing significant improvements in dynamic modulus and damping effectiveness.

Resorbable alginate embolic microsphere for Musculoskeletal embolization applications

This paper develops resorbable alginate microspheres with controlled degradation for musculoskeletal embolization, showing they induce recoverable ischemic necrosis in targeted vessels.