Cellular Mechanics and Interactions

The paper uses photocrosslinking to alter tissue stiffness in embryonic lungs and shows it inhibits epithelial budding morphogenesis.

The paper develops a model combining active fluid theory with experimental data to predict cell shape changes in epithelial tissues.

The paper explains spiral epithelial cell migration on corneas using a soft active matter model that incorporates cell division, extrusion, and collective migration.

This study shows that stiffening the tumor microenvironment via collagen alignment and crosslinking promotes M2 macrophage polarization, enhances immune suppression, and supports cancer cell growth.

This study shows that substrate stiffness affects neuronal maturation by regulating Piezo1-mediated TTR activity, delaying synapse formation and electrical maturation.

This study shows that D-chiral collagen-mimetic peptides reduce cell spreading and adhesion by destabilizing integrin interactions, highlighting the role of ECM chirality in cell migration.

This study shows SLK and Ezrin affect actin cytoskeleton organization independently of phosphorylation, revealing non-enzymatic roles for Ezrin in cytoskeletal dynamics.

This study shows that the shape of engineered eggshells influences vascular network organization in chick chorioallantoic membrane by altering vessel morphology and flow dynamics.

The paper shows dynamic forces from tissue movements shape the Kupffers vesicle in zebrafish embryos, confirmed by modeling and laser ablation experiments.

This study shows how muscle contractions and anisotropic tension drive polarized elongation of epidermal adherens junctions in C. elegans embryos.

This paper develops and characterizes 50 nm diameter genetically encoded multimeric nanoparticles (GEMs) for improved nanorheology studies.

The paper quantifies cell flows during avian gastrulation using a Dynamic Morphoskeleton model and identifies the mechanistic roles of attractors and repellers in shaping the embryo.

The paper investigates how substrate rigidity affects oscillatory behavior in zebrafish presomitic mesoderm cells, finding a switch-like transition at a critical rigidity threshold.

The paper investigates how WRC recruitment at tricellular junctions via Sidekick and Lar drives protrusive activity, enabling cell intercalation and tissue elongation in Drosophila.

This study identifies Vangl1 as a key mediator of flow-dependent cell dynamics in vascular remodeling through planar cell polarity signaling.

This study investigates how matrix stiffness and obesity-associated signaling influence PANC-1 pancreatic cancer cell behavior in vitro, showing increased invasiveness and amoeboid morphology under combined conditions.

This study shows PLEKHA7 regulates ECM remodeling and cell behavior via miRNA-mediated control of MMP1 and LOX in colon epithelial cells.

This study uses a continuum mechanics framework to show that epithelial tissues regulate energy expenditure to maintain efficient migration, and demonstrates this through electrotaxis experiments.

This study investigates the migratory behavior of enucleated and non-enucleated cells, showing that locomotion is regulated by systemic, self-organized dynamics.

This study shows that substrate stiffness affects the collective expansion of Myxococcus xanthus colonies, with adventurous motility playing a key role in sensing and responding to surface stiffness.

This study shows that cell-matrix forces increase during the loss of naive pluripotency in mESCs and are required for this process.

This study identifies fascin-1's role in promoting anchorage-independent proliferation through a novel signaling complex called PASS, which drives Rac1/PAK/JNK signaling in cancer cells.

The paper investigates how cells adapt to transport oversized parasitic cargo by reprogramming mechanical forces and subcellular architecture during migration.

This paper develops a biophysical model to predict F-actin stress fiber localization and force during cell migration using cell trajectory data from time lapse microscopy.

This study investigates how differences in cellular mechanics and ECM dynamics contribute to the distinct development of wing and haltere in Drosophila.

The paper demonstrates that membrane curvature catalyzes actin nucleation through the condensation and activation of N-WASP by FBP17, revealing a curvature-guided mechanism for actin remodeling.

The paper quantitatively analyzes cell migration trajectories across species and stimuli, finding that directional movement results from systemic, integrative cellular processes rather than individual molecular components.

The paper introduces a method combining lightsheet microscopy with optical visco-elastography to analyze single-cell mechanics and fluorescence in 3D live tissues, revealing new insights into cellular interactions.

This study shows that cancer cell-derived extracellular matrix promotes fibroblast differentiation into cancer-associated fibroblasts by increasing expression of CAF markers.