Ultrasound and Hyperthermia Applications

Transcranial focused ultrasound modulates visual thalamus in a nonhuman primate model

This study shows that transcranial focused ultrasound can modulate visual thalamus and affect connected cortical areas in a nonhuman primate model.

Noninvasive ultrasound targeted modulation of calcium influx in splenic immunocytes potentiates antineoplastic immunity attenuating hepatocellular carcinoma proliferation

This study uses ultrasound to modulate calcium influx in splenic immunocytes, enhancing antitumor immunity and significantly suppressing hepatocellular carcinoma growth.

Dual-Targeted Microbubbles Promote Apoptosis of M1 Macrophages by Inhibiting Telomerase Activity for Atherosclerosis Therapy

This study develops a dual-targeted microbubble system that inhibits telomerase activity in M1 macrophages, promoting apoptosis and slowing atherosclerosis progression.

Transcranial focused ultrasound stimulation of the anterior temporal lobe enhances semantic memory by modulating brain morphology, neurochemistry and neural dynamics

This study shows that transcranial ultrasound stimulation of the anterior temporal lobe improves semantic memory by altering brain structure, chemistry, and function.

Ultrasound Directly Activates Sparse Neurons and Modulates Visual Circuits in Deafened Mice

This study shows ultrasound directly activates sparse neurons in deafened mice, modulates visual circuits, and confirms direct mechanical effects independent of auditory input.

Ultrasonic Modulation of Astrocytic and Neuronal Calcium Dynamics in Mouse Cortex

This study investigates how low-frequency focused ultrasound affects astrocyte and neuronal calcium dynamics in mouse cortex, finding state-dependent effects with greater astrocytic response in awake mice.

Portable transcranial therapeutic ultrasound enhances targeted gene delivery for Parkinson's disease: from rodent models to non-human primates

Portable therapeutic ultrasound enhanced AAV9 delivery to the brain in mice and rhesus macaques compared to systemic injection alone.

Empirical Model of Focused Ultrasound-mediated Treatment for Chemotherapy Delivery

This study develops an empirical model linking drug particle properties and FUS parameters to therapeutic effectiveness in brain tumor treatment.

Integrated Ultrasound Neuromodulation and Optical Neuroimaging in Awake Mice using a Transparent Ultrasound Transducer Cranial Window

This paper introduces a transparent ultrasound transducer cranial window for integrating ultrasound neuromodulation and optical neuroimaging in awake mice, showing increased cerebral blood flow and hemoglobin with stimulation.

Focused Ultrasound modulates dopamine in a mesolimbic reward circuit

This study shows that low-intensity focused ultrasound at 13 W/cm2 reduces dopamine release in the nucleus accumbens core by ~50% for up to 2 hours without causing tissue damage.

Characterisation of Gas Vesicles as Cavitation Nuclei for Ultrasound Therapy using Passive Acoustic Mapping

This study characterizes gas vesicles as cavitation nuclei for ultrasound therapy using passive acoustic mapping and finds that cavitation activity diminishes rapidly after the first pulse.

Acoustic pH sensor for dynamic ultrasound imaging of cellular acidification

The paper introduces an acoustic pH sensor called pHonon for deep tissue imaging of cellular acidification using nonlinear ultrasound.

Characterization of Microbubble Cavitation in Theranostic Ultrasound-mediated Blood-Brain Barrier Opening and Gene Delivery

This study characterizes microbubble cavitation in theranostic ultrasound-mediated BBB opening and gene delivery, finding that longer pulses and specific microbubble sizes enhance cavitation and transgene expression.

Combined Nanodrops Imaging and Ultrasound Localization Microscopy for Detecting Intracerebral Hemorrhage

This paper introduces a combined imaging technique using ultrasound localization microscopy and nanodrop imaging to detect intracerebral hemorrhage in rodent models.

Spinal Cord Ultrasound Stimulation Modulates Corticospinal Excitability

This study investigates how spinal cord ultrasound stimulation affects corticospinal excitability using varying acoustic parameters and finds that high intensity and high PRF reduce motor-evoked potential amplitudes.

Programmable Assembly and Steering of Microbubble Droplets using Ultrasound

This paper introduces a new microbubble design that enables controlled assembly and acoustic steering for biomedical applications.

Label free, capillary-scale blood flow mapping in vivo reveals that low intensity focused ultrasound evokes persistent dilation in cortical microvasculature

This study uses an in vivo optical approach to show that low intensity focused ultrasound causes persistent microvascular dilation without microbubbles, suggesting vascular mechanisms may contribute to long-term neuromodulatory effects.

Characterization of focused ultrasound blood-brain barrier disruption effect on inflammation as a function of treatment parameters

This study examines how FUS intensity and microbubble dose affect BBB disruption, microhemorrhage, and inflammation in mice brains, and evaluates sex differences and repeated treatment effects.

Acoustic tumor paint for real-time imaging, surgical guidance and recurrence monitoring of brain tumors with ultrasound

In vivo Imaging and Pharmacokinetics of Percutaneously Injected Ultrasound and X-ray Imageable Thermosensitive Hydrogel loaded with Doxorubicin versus Free Drug in Swine

This study evaluates a thermosensitive hydrogel loaded with doxorubicin for targeted drug delivery in swine, showing reduced systemic exposure and improved localization compared to free drug injection.

Characterizing microbubble-mediated permeabilization in a vessel-on-a-chip model

This study uses a microvessel-on-a-chip model to compare the effects of short and long ultrasound cycles on vascular permeability and sonoporation induced by microbubbles.

TRPC6 is a mechanosensitive channel essential for ultrasound neuromodulation in mammalian brain

This study identifies TRPC6 as a critical mechanosensitive channel required for ultrasound-induced neuromodulation in mammalian neurons.

Ultrasound-activated microbubbles mediate F-actin disruptions and endothelial gap formation during sonoporation

This study shows ultrasound-activated microbubbles disrupt F-actin and create endothelial gaps, facilitating drug delivery through sonoporation.

Effect of Microbubble Size, Composition and Multiple Sonication Points on Sterile Inflammatory Response in Focused Ultrasound-Mediated Blood-Brain Barrier Opening

This study examines how microbubble size, composition, and sonication points affect blood-brain barrier opening and sterile inflammatory response in mice.

Non-invasive imaging of cell-based therapies using acoustic reporter genes

This paper develops a non-invasive ultrasound-based method to track cell-based therapies using acoustic reporter genes in primary mammalian cells.

Ventricle stimulation as a potential gold-standard control stimulation site for transcranial focused ultrasound stimulation

This paper evaluates ventricle-focused ultrasound stimulation as a control for transcranial FUS, finding it does not alter brain structure or function and is indistinguishable from sham stimulation.

Microscopic deconstruction of cortical circuit stimulation by transcranial ultrasound

This study uses TUS and calcium imaging in awake mice to show focal effects on cortical activity and proposes a circuit model explaining these effects.

Tumor Priming by Ultrasound Mechanogenetics for with SynNotch CAR T Therapy

This paper develops a system using ultrasound to remotely stimulate gene expression in tumors, enabling precise CAR T cell activation for immunotherapy.

Repeated low-intensity focused ultrasound induces microglial profile changes in the TgF344-AD rat model of Alzheimer's disease

This study investigates the effects of repeated low-intensity focused ultrasound (LiFUS) with microbubbles on microglial profiles in a rat model of Alzheimer's disease, finding both short-term and long-term changes in inflammation and amyloid levels.

Examination of low-intensity focused ultrasound parameters for human neuromodulation

This study examines how different parameters of low-intensity focused ultrasound affect human brain activity, finding inhibition in some cases and no excitation.