3D Printing in Biomedical Research

Curved by Design: Applying Microfluidic Principles for Nonplanar and Planar Suspended Tissue Patterning to the Development of Bladder Models with Tunable Mechanics

The paper develops the STEAM platform for creating suspended 3D bladder models with tunable mechanics and spatial complexity.

Bifunctional methacryloyl-norbornene gelatin chemistry enables tunable bioinks for soft tissue engineering via digital light processing

This paper develops a bifunctional gelatin-based bioink for 3D bioprinting, showing improved tunability and cell viability compared to existing formulations.

A mechanically actuated lung microvascular model reveals that breathing-like deformation enhances tumor cell extravasation

Defining a Biofabrication Window for Visible-Light Photocrosslinkable Protein Bioinks in Extrusion Bioprinting

The paper defines optimal photocrosslinking conditions for three protein-based bioinks in extrusion bioprinting, showing their cytocompatibility and structural fidelity.

Microdomes: Micro-engineered Microdome arrays enable standardised and shear-free 3D biology with full-spectrum optical imaging compatibility

The paper introduces Microdomes, a 3D biology platform that enables shear-free handling and full-spectrum optical imaging of spheroids and organoids.

Engineering a Multilayer Microfluidic Airway-On-A-Chip with Tunable GelMA Hydrogel for Physiologically Relevant Aerosol Exposure Studies

This paper develops a microfluidic airway-on-a-chip with GelMA hydrogel for studying smoke-induced airway responses, showing inflammatory and fibrotic effects from TGF-β1 and wood smoke exposure.

Modelling and measuring effects of shear stress in extrusion bioprinting of endothelial- epithelial cell co-cultures

The paper develops a workflow combining rheology, CFD modeling, and experiments to assess shear stress effects on cell viability during extrusion bioprinting of co-cultures.

A mammary-specific microfluidic device for studying post-radiotherapy vascular-immune cell interactions

This paper develops a mammary-specific microfluidic device to study how radiotherapy affects vascular-immune interactions and promotes pre-metastatic niche formation.

A fibril-inducing support-bath enables embedded 3D printing of aligned collagen-rich constructs

This paper introduces a fibril-inducing support bath that enables embedded 3D printing of aligned collagen-rich constructs with improved print fidelity and post-deposition stability.

3D bioprinting of engineered living materials in support slurries for complex free-standing structures

This paper presents a low-cost, open-source 3D bioprinting platform for creating complex bacterial structures with high dimensional accuracy and viability.

Small Intestinal Submucosa (SIS)-dECM Bioink with Extrusion-Induced Collagen Organization for Tympanic Membrane Tissue Engineering

This study develops a bioink using decellularized small intestinal submucosa to create a printable scaffold that promotes collagen organization for tympanic membrane regeneration.

Modeling Risk Group 4 virus infection and antiviral treatment in microfluidic lung organ-on-chips in maximum containment laboratories

The paper demonstrates the use of microfluidic lung organ-on-chips to model NiV infection and evaluate antiviral treatments in a biosafety level 4 lab.

Programmable bioprinting of tumor microenvironment arrays reveals laminin-dependent drug sensitivity

This study introduces a programmable bioprinting toolhead that creates tumor microenvironment gradient arrays, revealing that laminin-511 enhances drug-induced cell death in breast cancer models.

Bioprinted Human Primary Arteries Recapitulate Inflammatory Activation and Pharmacologic Rescue

This study develops a bioprinted artery-on-a-chip model to study inflammatory responses and test drug efficacy in human arteries.

Optimizing 3D Spheroid Formation in Microwells via a Simple Pluronic F127 Coating

This paper evaluates the use of Pluronic F127 coating to enhance spheroid formation in microwells by reducing cell-substrate adhesion.

Spatial control of light-responsive proteins and optogenetics within hydrogels via volumetric bioprinting

This study uses volumetric bioprinting to enable post-printing optogenetic stimulation of cells within hydrogel constructs, demonstrating spatial control over light-responsive proteins and gene expression.

Patterned ELR-Gelatin Hydrogels Enable Rapid Endothelial Monolayer Formation via Bioactive Matrix Chemistry and Surface Topography

Scalable 3D Bioprinting of Human Islets in a Pancreatic Decellularized Extracellular Matrix-Enriched Bioink for Beta-Cell Replacement Therapy

This paper develops a 3D bioprinting method using decellularized extracellular matrix-enriched bioinks to create functional human islet constructs for beta-cell replacement therapy in type 1 diabetes.

Engineered cell-like vesicles instruct keratocyte differentiation for corneal biofabrication and regeneration

The paper uses growth factor-loaded vesicles to direct keratocyte differentiation in 3D corneal constructs without repeated soluble growth factor supplementation.

Photoinitiator-free visible-light bioprinting: minimising radical-induced oxidative stress and DNA damage in gelatin hydrogels

This paper introduces a photoinitiator-free gelatin hydrogel system that enables visible-light-induced crosslinking, reducing oxidative stress and DNA damage in cell culture.

A Compact, Standalone & Battery-Powered 3D Organoid-on-Chip System with Programmable Flow Control

The paper introduces a compact, battery-powered organoid-on-chip system with programmable flow control, validated for culturing pancreatic cancer organoids and showing enhanced proliferation and drug response.

Microfluidic Tissue Array Platform for Personalized Drug Screening Using Tumor Explants or Biopsies

This paper develops a microfluidic tissue array platform for personalized drug screening using tumor explants or biopsies, showing reduced tumor cell viability and proliferative cell retention after treatment.

Degradable porous PLGA/PCL membrane enable a lung alveoli-on-a-chip for modeling particulate-induced alveolar injury

This paper develops a degradable PLGA/PCL membrane for a lung alveoli-on-a-chip system to model particulate-induced alveolar injury and assess therapeutic responses.

Tomographic Printing in a Chip: A Versatile Platform for Biomimetic 3D Organ-on-Chip

This paper introduces a new 3D organ-on-chip platform using tomographic volumetric additive manufacturing integrated into microfluidic chips, enabling rapid and reproducible fabrication of complex biological models.

Computational fluid dynamics enables predictable scale-up of perfusion bioreactors for microvessel production

This paper uses computational fluid dynamics to guide the scaling of perfusion bioreactors, showing that maintaining interstitial flow ensures reproducible microvessel networks across 30-fold volume increases.

Bespoke sustainable 3D-printed labware for enhanced handling and standardization of tumor spheroid migration and invasion assays

The paper introduces a 3D-printed platform for standardized tumor spheroid invasion assays, reducing variability and enhancing reproducibility.

Comparison of hiPSC-derived hepatic organoids and liver-on-a-chip systems reveal microenvironment-driven maturation

This study compares hiPSC-derived hepatic organoids and liver-on-a-chip systems, showing that microfluidic flow enhances hepatic maturation and metabolic specialization.

Self-Actuating 4D Cell-Strand Bioprinting

This paper introduces a self-actuating 4D cell-strand bioprinting platform that generates complex tissue architectures through autonomous cell contractile force-driven morphing.

Ovarian cancer-on-chip for patient-specific profiling of treatment responses to sequential chemotherapy and PD-L1 blockade

This paper develops an OvCa-on-chip platform to profile patient-specific treatment responses to chemotherapy and PD-L1 blockade.

Spatiotemporal bioprinting of microtissues and growth factors within a support bath to engineer anisotropic, zonally defined meniscal grafts

This paper develops a bioprinting method to create zonally defined meniscal grafts using growth factors and MSC-derived microtissues, resulting in scaffold-free tissues with region-specific ECM composition.