Retinoids in leukemia and cellular processes

Tumor suppressor-like mutations mark a dosage-constrained dependency in leukemia

The paper shows that oncogene-imposed dosage constraints can lead to mutations resembling tumor suppressor loss, which are essential in APL.

AN OPTIMIZED METHOD TO DIFFERENTIATE HL60 CELLS INTO NEUTROPHIL-LIKE CELLS

The paper introduces an optimized differentiation protocol for HL60 cells to generate neutrophil-like cells with improved morphology and functionality compared to traditional methods.

Biological differences in promyelocytic leukemia (PML) proteins between PML-nuclear bodies (PML-NBs) and extranuclear PML bodies (EnPBs) in arsenite-exposed cells.

This study examines how arsenite exposure affects PML protein solubility and SUMOylation, leading to changes in PML-NBs and EnPBs in cultured cells.

PML-driven sumoylation of PML/RARA-bound co-repressors drives immortalization of primary hematopoietic progenitors

The paper shows that PML/RARA fusion promotes hematopoietic progenitor immortalization via PML-driven sumoylation of NCoR, enhancing transcriptional repression and contributing to APL pathogenesis.

Retinoic acid production via the ray-finned fish gene beta-carotene oxygenase 1-like is essential for juvenile development

This study shows that bco1l is essential for VA production in betta fish larvae, leading to developmental defects when knocked out.

New structural insights into the control of the retinoic acid receptors RAR/RXR by DNA, ligands and transcriptional coregulators

This study reveals how DNA sequence and ligand binding influence the structural dynamics of RAR/RXR-coregulator complexes through integrative structural analysis.

Targeting USP2 induces degradation of PML-RARα with or without drug-resistant mutations in acute promyelocytic leukemia

This study shows that inhibiting USP2 reduces PML-RAR protein levels in APL cells, including those with drug-resistant mutations, and induces apoptosis.

FGR Src Family Kinase Causes Signaling and Phenotypic Shift Mimicking Retinoic Acid-Induced Differentiation of Leukemic Cells

The paper shows that FGR Src-family kinase induces differentiation in leukemic cells similar to retinoic acid, by mimicking its signaling and phenotypic effects.

Loss of the systemic vitamin A transporter RBPR2 affects the quantitative balance between chromophore and opsins in visual pigment synthesis

This study shows that loss of RBPR2 affects retinoid homeostasis and visual pigment synthesis, leading to visual function defects in mice under vitamin A deficiency.

VITAMIN A DEFICIENCY CAUSES APOPTOSIS IN THE MAMMARY GLAND OF RATS

This study shows that vitamin A deficiency in rats leads to mammary gland dysfunction through increased inflammation, apoptosis, and reduced cell proliferation, which can be reversed with a vitamin A sufficient diet.

Acute promyelocytic leukemia with torque teno mini virus (TTMV)::RARA fusion: an approach to screening and diagnosis

The paper describes a clinicopathologic approach and tools for diagnosing APL with TTMV::RARA fusion using NGS assays, identifying four cases with poor treatment outcomes.

Enhanced loss of retinoic acid network genes in Xenopus laevis achieves a tighter signal regulation

The paper investigates gene loss in the retinoic acid network of Xenopus laevis and finds that enhanced loss of RA metabolism genes leads to tighter network regulation.

Retinoic acid fluctuation activates an uneven, direction-dependent network-wide robustness response in early embryogenesis

The paper investigates RA network robustness during embryogenesis, finding direction-dependent trade-offs in feedback responses that affect developmental outcomes.

A novel retinoic acid analog, 4-Amino-2-Trifluoromethyl-Phenyl Retinate (ATPR) triggers differentiation and is effective in the treatment of Acute Promyelocytic Leukemia

This study investigates ATPR's therapeutic effect on APL by showing it induces differentiation and modulates PI3K/AKT, ERK, and Notch signaling in a xenograft model.

TNF-α differentially regulates cell cycle genes in promyelocytic and granulocytic HL-60/S4 cells

This study shows TNF-α induces different cell cycle gene responses in promyelocytic and granulocytic HL-60/S4 cells, with promyelocytes showing upregulation and granulocytes downregulation, and granulocytes shifting towards a macrophage-like transcriptome.