Zebrafish Biomedical Research Applications

Remembering the opponent: neuronal activation associated with social memory in Zebrafish

The paper investigates neuronal activation in zebrafish during social memory tasks, finding differential activation in specific telencephalic nuclei based on memory of previous agonistic encounters.

Behavioural pharmacology predicts disrupted signalling pathways and candidate therapeutics from zebrafish mutants of Alzheimer's disease risk genes

Exploration of phosphoproteomic association during epimorphic regeneration

This study maps phosphoproteomic changes during zebrafish caudal fin regeneration, identifying key signaling pathways and highlighting the role of phosphorylation in tissue regeneration.

Optogenetic interrogation of the lateral-line sensory system reveals mechanisms of pattern separation in the zebrafish brain

The paper uses optogenetic stimulation and calcium imaging in zebrafish to study how sensory inputs from neuromasts are processed in the brain, revealing nonlinear integration and sparse neuronal representations.

Anti-Parkinsonian Drugs Rescue Locomotor Deficits in JIP3 Knockout Zebrafish: Implications for Treating Patients with MAPK8IP3-related Neurodevelopmental Disorders

The paper identifies amantadine and levodopa as potential therapies for JIP3-related neurodevelopmental disorders using zebrafish models and AI-assisted drug screening.

Marigold: A machine learning-based web app for zebrafish pose tracking

Marigold is a web-based tool for zebrafish behavior analysis that enables high-throughput tracking of pose and kinematic parameters across diverse experimental setups.

LEVERAGING TRANSFER LEARNING FOR HIGH-ACCURACY PHENOTYPIC SCREENING IN ZEBRAFISH IMAGE ANALYSIS

This paper presents a transfer learning method for classifying zebrafish images before and after drug treatment, achieving high accuracy in detecting phenotypic changes.

p16.1 and p16.2, new HSPC markers, play redundant roles in zebrafish T-cell lymphopoiesis

The paper identifies p16.1 and p16.2 as new HSPC markers in zebrafish that redundantly support T-cell lymphopoiesis, with compensation via upregulated chemotaxis genes in double mutants.

Crispant analysis in zebrafish as a tool for rapid functional screening of disease-causing genes for bone fragility

This study uses zebrafish crispant screening to functionally validate disease-causing genes for bone fragility disorders, showing consistent skeletal phenotypes and differential gene expression in affected models.

Serotonergic mediation of orienting and defensive responses in zebrafish

This study shows that serotonergic signaling in zebrafish modulates the shift from orienting to defensive responses when exposed to alarm cues.

Developing a zebrafish xenograft model of diffuse midline glioma

This paper develops a zebrafish xenograft model for diffuse midline glioma by transplanting human DMG cells into zebrafish embryos to enable high-throughput drug screening.

Development of sensorimotor responses in larval zebrafish: a comparison between wild-type and GCaMP6s transgenic line

The paper compares sensorimotor responses in wild-type and GCaMP6s transgenic zebrafish larvae, finding a developmental switch in light and vibration responses but no major difference in response maturation.

An Image Processing Tool for Automated Quantification of Bacterial Burdens in Zebrafish Larvae

The paper develops an automated image processing tool to quantify bacterial burdens in zebrafish larvae by detecting their borders to distinguish internal from external bacteria.

Identification of potential sepsis therapeutic drugs using a zebrafish rapid screening approach

This study identifies three FDA-approved drugs that rescue zebrafish from sepsis-like endotoxicity with no neurobehavioral side effects.

Transsynaptic labeling and transcriptional control of zebrafish neural circuits

This study maps transsynaptic connections in zebrafish neural circuits using a modified trans-Tango method and validates findings with optogenetic experiments.

Engineering an fgfr4 knockout zebrafish to study its role in development and disease

This study generates and characterizes fgfr4 knockout zebrafish to investigate FGFR4's role in development and disease.

Social isolation reduces oxygen consumption, speed of movement and social preference in wild-type Zebrafish (Danio rerio)

Environmental Enrichment Reduces adgrl3.1-Related Anxiety and Attention Deficits but Not Impulsivity

This study shows environmental enrichment reduces anxiety and attention deficits but not impulsivity in adgrl3.1 knockout zebrafish, indicating genetic and environmental interactions in behavioral traits.

Physical constraints on the positions and dimensions of the zebrafish swim bladder by surrounding bones

This study shows that the size and position of the zebrafish swim bladder are physically constrained by surrounding bones during development.

Uncovering multiscale structure in the variability of larval zebrafish navigation

The paper develops a method to analyze behavioral variability in larval zebrafish by identifying motor strategies and their transitions across different environmental cues.

Social Isolation Intensifies adgrl3.1-Related Externalizing and Internalizing Behaviors in Zebrafish

The paper examines how social isolation interacts with a genetic mutation to intensify both externalizing and internalizing behaviors in zebrafish.

LabEmbryoCam: An opensource phenotyping system for developing aquatic animals

LabEmbryoCam is an open-source phenotyping system for timelapse imaging of aquatic embryos, enabling automated analysis of developmental traits.

FEHAT: Efficient, Large scale and Automated Heartbeat Detection in Medaka Fish Embryos.

FEHAT automatically detects heart rates in Medaka fish embryos from high-resolution videos, showing reliable performance across temperature perturbations.

Etomidate as an Effective Alternative Method of Euthanizing Adult Zebrafish (Danio Rerio)

This study evaluates etomidate concentrations and fish densities for euthanizing adult zebrafish, finding both concentrations effective with shorter times at higher concentrations and lower densities.

Identification of a specific granular marker of zebrafish eosinophils enables development of new tools for their study

The paper identifies a specific marker for zebrafish eosinophils and develops new tools to study their biology and function in disease.

Pallium tracks valence-specific chemosensory amplification of eye-body coordination in larval zebrafish

This study shows how chemosensory cues affect eye-body coordination in larval zebrafish, with aversive cues enhancing coordination and food cues promoting forward movement.

VICR: A Novel Software for Unbiased Video and Image Analysis in Scientific Research

VICR is a software tool for unbiased video and image analysis that segments and randomizes data to eliminate bias, demonstrated using zebrafish behavior studies.

Parental thermal conditions affect the brain activity response to alarm cue in larval zebrafish

This study shows that parental exposure to elevated temperature affects larval zebrafish brain activity response to alarm cues, with interactions between parental and offspring thermal conditions influencing response duration.

Anatomical and functional organization of the interpeduncular nucleus in larval zebrafish

This study characterizes the anatomical and functional organization of the interpeduncular nucleus in larval zebrafish using multiple imaging and histological techniques.

A complete account of the behavioral repertoire uncovers principles of larval zebrafish hunting behavior

The paper develops a mathematical model to capture the complete behavioral repertoire of larval zebrafish hunting, revealing principles of movement and orientation during prey interaction.