Fibroblast Growth Factor Research

FGF signaling regulates salivary gland branching morphogenesis by modulating cell adhesion

This study shows that FGF signaling regulates salivary gland branching by modulating cell adhesion, with non-canonical mechanisms involved.

Wengen, a Tumour Necrosis Factor Receptor, regulates the Fibroblast Growth Factor pathway by an unconventional mechanism

The paper shows that Wengen, a TNFR, regulates the FGFR pathway by an unconventional mechanism involving intracellular trafficking and interaction with Breathless.

Protein preference and elevated plasma FGF21 induced by dietary protein restriction is similar in both male and female mice

The paper finds that male and female mice show similar protein preference and plasma FGF21 responses to dietary protein restriction, with no effect of estrous cycle stage on preference or FGF21 levels during restriction.

FGF21 Counteracts Alcohol Intoxication by Activating Noradrenergic Neurons

This study shows FGF21 reduces ethanol-induced intoxication by activating noradrenergic neurons, improving recovery from ethanol exposure in mice.

GPI-anchored FGF directs cytoneme-mediated bidirectional signaling to self-regulate tissue-specific dispersion

The paper shows GPI-anchored FGF directs bidirectional cytoneme-mediated signaling between cells to regulate tissue-specific dispersion and signaling.

FGF21-FGFR4 signaling in cardiac myocytes promotes concentric cardiac hypertrophy in mouse models of diabetes

This study shows that FGF21-FGFR4 signaling in cardiac myocytes causes concentric hypertrophy in diabetic mice, suggesting it may contribute to HFpEF and that FGFR4 blockade could be a therapeutic target.

Quantitation of FGFR3 signaling via GRB2 recruitment on micropatterned surfaces

The paper quantifies FGFR3 signaling in live cells using micropatterned surfaces and GRB2 recruitment, showing ligand-dependent and mutant-specific activation patterns.

Bromodomain inhibition reveals FGF15/19 as a target of epigenetic regulation and metabolic control

The paper shows that inhibiting bromodomain proteins like BRD4 reduces FGF15/19 expression, leading to hyperglycemia, and that overexpressing FGF19 can reverse these effects.

Integrative Modelling of Signalling Network Dynamics Identifies Cell Type-selective Therapeutic Strategies for FGFR4-driven Cancers

The paper develops a computational model of FGFR4 signalling to identify cell type-selective combination therapies for FGFR4-driven cancers, revealing AKT and ERK reactivation as key resistance mechanisms.

Mice with High FGF21 Serum Levels Had a Reduced Preference for Morphine and an Attenuated Development of Acute Antinociceptive Tolerance and Physical Dependence

This study shows that mice with high FGF21 levels have reduced morphine preference and less acute opioid tolerance and dependence.

Characterization of a novel Fgf10CreERT2 knock-in mouse line targeting postnatal lung Fgf10 lineages

The paper describes the development and validation of a new Fgf10CreERT2 mouse line (Fgf10Ki-v2) that effectively targets Fgf10-positive cells in adult lungs, overcoming limitations of an earlier version.

Role of hypothalamic MAPK/ERK signaling in diabetes remission induced by the central action of fibroblast growth factor 1

This study shows that sustained hypothalamic MAPK/ERK signaling is essential for FGF1-induced diabetes remission in rodents.

FGF signaling in development beyond canonical pathways

This study investigates FGF signaling beyond canonical pathways by analyzing Fgfr1 and Fgfr2 mutations in mice, revealing novel kinase-dependent cell adhesion properties independent of traditional signaling cascades.

FGF signaling dynamics regulates epithelial patterning and morphogenesis

The paper investigates how FGF signaling dynamics influence epithelial morphogenesis by analyzing mammary organoids and using mathematical modeling.

FGF9 and FGF10 use distinct signaling pathways to direct lung epithelial specification and branching

This study shows FGF9 and FGF10 use distinct FGFRs and signaling pathways to regulate lung epithelial development and branching.

Fibroblast Growth Factor 21 (FGF21) creates sugar-specific taste aversion to fructose through action in the brain in mice.

This study shows that FGF21 suppresses fructose preference in mice but not glucose or sucrose, and this effect requires central β-klotho expression.

A pleiotropic role for FGF signaling in mammary gland stromal fibroblasts

This study identifies FGF signaling's role in mammary fibroblasts, showing it regulates proliferation, migration, ECM production/remodeling, and epithelial branching.

Fibroblast growth factor receptors function redundantly during zebrafish embryonic development

The paper analyzes fibroblast growth factor receptor mutants in zebrafish, revealing functional redundancy that ensures robustness in developmental signaling.

A common allele in FGF21 associated with preference for sugar consumption lowers body fat in the lower body and increases blood pressure

A common FGF21 allele is associated with lower body fat in the lower body, higher blood pressure, and increased carbohydrate intake in a large human cohort.