Fibroblast Growth Factor Research

A hypothalamus-liver-skeletal muscle axis controlled by JNK1 and FGF21 mediates olanzapine-induced insulin resistance in an intraperitoneal treatment in male mice

This study shows that intraperitoneal olanzapine treatment in male mice causes insulin resistance via a hypothalamus-liver-skeletal muscle axis involving JNK1 and FGF21, with PTP1B deficiency offering protection.

Fibroblast growth factor receptor substrate 2 interactome mapping reveals novel candidate interactors associated with migration and invasion

This study maps the FRS2 interactome in medulloblastoma cells, identifying novel proteins involved in cell migration and invasion, and highlights FRS2's role in tumor aggressiveness.

Cellular responses to FGF1 are modulated by palmitoylation of the docking protein FRS2α

This study shows that palmitoylation of FRS2α is essential for FGF1-induced signaling and cellular responses, including MAPK activation and neuronal differentiation.

Glycerol-3-phosphate activates ChREBP, FGF21 transcription and lipogenesis in Citrin Deficiency

This study identifies G3P-ChREBP as a mechanism linking Citrin Deficiency to metabolic dysfunction by activating FGF21 and lipogenesis, affecting food and alcohol choices.

Discovery and optimization of a guanylhydrazone-based small molecule to replace bFGF for cell culture applications

The paper identifies and optimizes a guanylhydrazone-based small molecule that mimics bFGF's function in cell culture, showing improved potency and thermal stability.

FGF21 Analogue PF-05231023 on Alcohol Consumption and Neuronal Activity in the Nucleus Accumbens

This study evaluates the effects of PF-05231023, an FGF21 analogue, on alcohol consumption and neuronal activity in the nucleus accumbens, showing reduced intake and altered neural responses.

The clinical antiprotozoal drug halofuginone promotes weight loss by elevating GDF15 and FGF21

This study shows halofuginone, an FDA-approved drug, reduces obesity in mice by increasing FGF21 and GDF15 levels, improving metabolic health.

FGF21 acts in the brain to drive macronutrient-specific changes in behavioral motivation and brain reward signaling

This study shows that FGF21 in the brain enhances the reward value of protein, increasing motivation to consume it during protein restriction.

Diverse Fgfr1 signaling pathways and endocytic trafficking regulate early mesoderm development

This study identifies diverse Fgfr1 signaling pathways and endocytic trafficking mechanisms that regulate early mesoderm development, revealing both canonical and non-canonical roles beyond traditional signaling cascades.

FRS2-independent GRB2 interaction with FGFR2 is not required for embryonic development

The paper shows that GRB2 binding to the C-terminal of FGFR2, independent of FRS2, is not essential for embryonic development or adult homeostasis.

Elucidating Fibroblast Growth Factor-induced kinome dynamics using targeted mass spectrometry and dynamic modeling

The paper quantifies kinase activity dynamics in response to FGF ligands and uses dynamic modeling to reveal pathway regulation and novel kinase involvement.

FGF signaling regulates salivary gland branching morphogenesis by modulating cell adhesion

This study shows that FGF signaling regulates salivary gland branching by modulating cell adhesion, with non-canonical mechanisms involved.

Protein preference and elevated plasma FGF21 induced by dietary protein restriction is similar in both male and female mice

The paper finds that male and female mice show similar protein preference and plasma FGF21 responses to dietary protein restriction, with no effect of estrous cycle stage on preference or FGF21 levels during restriction.

GPI-anchored FGF directs cytoneme-mediated bidirectional signaling to self-regulate tissue-specific dispersion

The paper shows GPI-anchored FGF directs bidirectional cytoneme-mediated signaling between cells to regulate tissue-specific dispersion and signaling.

FGF21-FGFR4 signaling in cardiac myocytes promotes concentric cardiac hypertrophy in mouse models of diabetes

This study shows that FGF21-FGFR4 signaling in cardiac myocytes causes concentric hypertrophy in diabetic mice, suggesting it may contribute to HFpEF and that FGFR4 blockade could be a therapeutic target.

Bromodomain inhibition reveals FGF15/19 as a target of epigenetic regulation and metabolic control

The paper shows that inhibiting bromodomain proteins like BRD4 reduces FGF15/19 expression, leading to hyperglycemia, and that overexpressing FGF19 can reverse these effects.

Mice with High FGF21 Serum Levels Had a Reduced Preference for Morphine and an Attenuated Development of Acute Antinociceptive Tolerance and Physical Dependence

This study shows that mice with high FGF21 levels have reduced morphine preference and less acute opioid tolerance and dependence.

FGF signaling in development beyond canonical pathways

This study investigates FGF signaling beyond canonical pathways by analyzing Fgfr1 and Fgfr2 mutations in mice, revealing novel kinase-dependent cell adhesion properties independent of traditional signaling cascades.

FGF9 and FGF10 use distinct signaling pathways to direct lung epithelial specification and branching

This study shows FGF9 and FGF10 use distinct FGFRs and signaling pathways to regulate lung epithelial development and branching.

A pleiotropic role for FGF signaling in mammary gland stromal fibroblasts

This study identifies FGF signaling's role in mammary fibroblasts, showing it regulates proliferation, migration, ECM production/remodeling, and epithelial branching.

Fibroblast growth factor receptors function redundantly during zebrafish embryonic development

The paper analyzes fibroblast growth factor receptor mutants in zebrafish, revealing functional redundancy that ensures robustness in developmental signaling.