Lung Cancer Research Studies

A gene program association study (GPAS) delineates novel patterns of lineage plasticity and aggressiveness in non-small cell lung cancer

The paper introduces GPAS to analyze gene co-expression modules in NSCLC, identifying lineage plasticity and aggressiveness patterns across different cancer subtypes.

DNA damage response signatures are associated with frontline chemotherapy response and routes of tumor evolution in extensive stage small cell lung cancer

This study identifies three distinct DDR phenotypes in SCLC associated with chemotherapy response and tumor evolution.

Comparative analysis of transcriptomic and proteomic expression between two non-small cell lung cancer subtypes

The paper compares transcriptomic and proteomic expression between two NSCLC subtypes to identify potential therapeutic targets and biomarkers.

Screening and identification of gene expression in large cohorts of clinical lung cancer samples unveils the major involvement of EZH2 and SOX2

The paper identifies EZH2 and SOX2 as key genes in LUAD through differential expression analysis and pathway enrichment, suggesting EZH2 as a potential therapeutic target.

Prognostic Significance of Potential Target Networks and P16INK4a In Early Diagnosis of Non-Small Cell Lung Cancer

This study identifies a prognostic signature involving p16INK4a and related genes in NSCLC, highlighting their potential as diagnostic and therapeutic biomarkers.

Patho-transcriptomic analysis of invasive mucinous adenocarcinoma of the lung (IMA): comparison with lung adenocarcinoma with signet ring cell features (SRCC)

This study compares the patho-transcriptomic profiles of invasive mucinous adenocarcinoma (IMA) and adenocarcinoma with signet ring cell features (SRCC), identifying distinct and shared gene expression patterns and potential therapeutic targets.

Data-driven structural analysis of Small Cell Lung Cancer transcription factor networksuggests potential subtype regulators and transition pathways

The paper analyzes the structure of SCLC transcription factor networks to identify subtype regulators and transition pathways using graph theory and RNA-seq data.

Comprehensive Analysis of Molecular Characteristics, Clinical Signifificance, and Cancer Immune Interactions of Patients by Anoikis-Related Genes in LUAD Combined with Single-cell Data

The paper identifies two LUAD clusters based on Anoikis-related genes, establishes a prognostic risk score, and shows its association with immune status and clinical outcomes using single-cell data.

Interrogating the Precancerous Evolution of Pathway Dysfunction in Lung Squamous Cell Carcinoma Using XTABLE

The paper introduces XTABLE, an open-source tool for analyzing PML transcriptomic data, and uses it to study chromosomal instability as a biomarker for LUSC progression and pathway onset.

Brief Report: Prognostic relevance of 3q amplification in squamous cell carcinoma of the lung

This study identifies a 25-gene minimal common region on 3q amplified in 44% of LUSC cases, associated with improved disease-specific survival and progression-free interval.

Study on the expression of RAD51 in non-small cell lung cancer based on bioinformatics

This study investigates RAD51 expression in non-small cell lung cancer using bioinformatics tools and finds it is highly expressed and associated with poor prognosis.

A comparative study of neuroendocrine heterogeneity in SCLC and NBL

This study compares neuroendocrine (NE) features in SCLC and NBL, finding similar molecular profiles and shared therapeutic responses but no significant survival association with NE scores.

Expression and relationship with immunity of LRFN4 in lung adenocarcinoma: Based on bioinformatics analysis

This study investigates LRFN4 expression and its association with immunity and prognosis in lung adenocarcinoma using bioinformatics analysis and experimental validation.

Selective Regulation of Tuft Cell-Like Small Cell Lung Cancer by Novel Transcriptional Co-activators C11orf53 and COLCA2

The paper identifies two understudied selectively essential genes, C11orf53 and COLCA2, as novel transcriptional co-activators in tuft cell-like SCLC, validated through computational ranking and experimental analysis.

Cancer Hallmarks Define a Continuum of Plastic Cell States between Small Cell Lung Cancer Archetypes

This study shows SCLC cells exist in a continuum of plastic states rather than discrete subtypes, with gene expression patterns linked to cancer hallmarks and potential therapeutic targets.

Transcriptional circuitry of NKX2-1 and SOX1 defines an unrecognized lineage subtype of small cell lung cancer

The paper identifies an epigenomic subtype of SCLC-A defined by NKX2-1 and SOX1 super-enhancers and their functional collaboration.

Comprehensive profiling of genomic and transcriptomic differences between risk groups of lung adenocarcinoma and lung squamous cell carcinoma

The paper identifies prognostic gene signatures and genomic differences between high-risk and low-risk groups in lung adenocarcinoma and squamous cell carcinoma using TCGA data.

Functional signatures in non-small-cell lung cancer: a systematic review and meta-analysis of sex-based differences in transcriptomic studies

This study performs a meta-analysis of transcriptomic data to identify sex-based differences in functional signatures of non-small-cell lung cancer, finding enrichment in immune response and purinergic signaling in females.

Genomic and TCR Repertoire Intratumor Heterogeneity of Small-cell Lung Cancer and its Impact on Survival

This study examines genomic and TCR repertoire heterogeneity in SCLC, finding that lower TCR heterogeneity and mutational burden correlate with better survival.

Systems biology analysis of publicly available transcriptomic data reveals a critical link between AKR1B10 gene expression, smoking and occurrence of lung cancer

The paper identifies AKR1B10 as a gene linked to smoking and lung cancer using transcriptomic data from six studies.

Systems-level network modeling of Small Cell Lung Cancer subtypes identifies master regulators and destabilizers

The paper identifies four SCLC subtypes using a systems approach, with NEv2 being a new subtype, and finds master regulators and destabilizers using BooleaBayes.

A comparative microarray analysis identifies a conserved gene expression signature between airway injury and lung cancer

The paper identifies a conserved gene expression signature linking airway injury and lung cancer using microarray analysis of murine and human samples.