Discover, rate, and verify biology preprints.

Repurposing the evolutionary fitness of marine bacteria for water-conserving conversion of lignin-derived carbon

The paper repurposes marine bacteria to convert lignin-derived carbon into valuable chemicals using seawater, achieving carbon and water conservation.

A T-cell engager platform induces deep plasma cell depletion in autoimmune dry eye

This paper introduces an in vivo TCE platform that depletes plasma cells in autoimmune dry eye models, showing efficacy and safety without ex vivo manufacturing.

A rapid, field-deployable paper-based biosensor for the detection of African swine fever virus in whole blood

This paper develops a portable biosensor for rapid ASFV detection in whole blood using microfluidic paper-based devices, achieving high sensitivity and specificity without DNA extraction.

Microbial production of the low-caloric sweetener D-allulose from D-glucose by evolutionary engineering

This paper evolves microbial strains to efficiently produce D-allulose from D-glucose, achieving a 15% yield at 30°C using engineered enzymes and a chassis strain.

Hybrid modeling framework for bioprocesses with minimal prior knowledge and limited data

This paper introduces a hybrid modeling framework that combines mechanistic ODEs with neural networks to model bioprocesses using minimal prior knowledge and limited data.

A Chairside Multimodal Platform for Temporomandibular Joint Biomechanical Assessment: Technical Evaluation and Illustrative Application

The paper develops a compact multimodal platform for synchronized TMJ biomechanical data acquisition and demonstrates its use in orthognathic surgery with submillimeter motion accuracy and excellent bite force linearity.

Characterization of time-dependent and history-dependent mechanical behaviour of human masseter muscle

This study investigates the time- and history-dependent mechanical behavior of human masseter muscle under cyclic tensile loading, showing strain-rate and preservation effects on stiffness and viscoelastic properties.

Vehiculation and functional delivery of lipophilic therapeutics and antibiotics via pulmonary surfactant in a lung-on-chip model

This study demonstrates the use of a lung-on-chip model to study drug vehiculation via pulmonary surfactant, showing effective delivery and suppression of Mycobacterium tuberculosis.

Injury Causes Altered Metabolism including O2 Consumption in Bovine and Human Chondrocytes

This study examines how mechanical injury alters metabolism in bovine and human chondrocytes, revealing differences in oxygen consumption and glutamine accumulation between healthy and osteoarthritic cells.

Engineering anaerobic fungal-bacterial consortia for direct conversion of lignocellulosic biomass into medium-chain fatty acids

This study engineers an anaerobic fungal-bacterial consortium to convert lignocellulosic biomass into medium-chain fatty acids without pretreatment, achieving a 21.0% conversion yield.

HipSAFE: automating hip fracture detection on ultrasound imaging using deep learning

HipSAFE uses deep learning to detect hip fractures on ultrasound images, achieving high accuracy comparable to x-rays, potentially improving triage in rural settings.

ZNF865 (BLST) Regulates Back Pain via Cell Senescence and DNA Damage Mechanisms

This study identifies ZNF865 as a regulator of cell senescence and DNA damage in intervertebral discs, showing its role in back pain and potential as a therapeutic target.

A dual-photoreactive adapter enables one-step DNA barcoding of antibody panels for multiplexed imaging

This paper introduces a dual-photoreactive adapter to enable rapid, one-step DNA barcoding of antibody panels for multiplexed imaging.

Ion Channel Nano-Diagnostics for ER+ Breast Cancer

This paper develops GAT1508-coated gold nanoparticles for detecting ER+ breast cancer cells through specific binding to GIRK1 channels, validated by flow cytometry and electrophysiology.

Deep learning based design of buried hydrogen bond networks with HBDesigner

This paper introduces HBDesigner, a deep learning tool for designing hydrogen-bond networks in proteins, showing improved performance over existing methods.

IMU-based upper limb kinematics validation: sensor fusion optimisation, sensor-to-segment alignment, and joint angle accuracy.

This paper validates an IMU-based framework for upper limb kinematics by optimizing sensor fusion, improving alignment, and evaluating joint angle accuracy across different alignment methods.

MR-ARFI and Beyond: Characterizing the Temporal Dynamics of Acoustic Radiation Force in Human Brain

This paper characterizes the temporal dynamics of acoustic radiation force in human brain tissue using MR-ARFI, finding that stiffer tissue exhibits shorter time constants and reduced displacement.

WHEN MICROSCALE TRANSPORT CONTROLS MACROSCALE TISSUE FREEZING: A PARAMETRIC REGIME ANALYSIS

This paper analyzes when microscale transport processes affect macroscale tissue freezing by expanding parameter space and introducing a dimensionless group to quantify model divergence.

A novel precision-cut lung slice stretch model using removable inflation materials

The paper introduces a novel PCLS model with removable hydrogel inflation to improve cyclic mechanical stretch studies and enable biochemical assays.

A Generative AI Framework to Predict Cardiomyocyte Contraction Function from Single Static Images.

This paper introduces a generative AI framework that predicts cardiomyocyte contraction from static images, achieving high accuracy and revealing structure-function relationships.