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Goal directed closed-loop training of network bursts in cortical cultures produces improved performance and error correction over days

The paper trains dissociated rat cortical cultures to control network burst initiation and error recovery over days using a closed-loop system, showing retention and consolidation of learned behaviors.

Cellulase catalysis on cell surfaces using Caulobacter S-layer display

This study uses Caulobacter S-layer display to express functional cellulases for lignocellulosic biomass conversion, demonstrating synergistic catalytic activities.

Mitochondrial and bioenergetic processes are enriched in large-but are reciprocally depleted in small extracellular vesicles

The paper shows that mitochondrial and bioenergetic processes are enriched in large EVs but depleted in small EVs using proteomics and gene-set enrichment analysis.

Fallopian Tube Organoid-Integrated Microfluidic Platform for Real-Time Imaging and Outflow Analysis

This paper develops a microfluidic platform integrating fallopian tube organoids to study epithelial function and disease, showing viable cultures and comparable cell health to intact organoids.

Hemodynamic Analysis of a Repaired Ascending Aorta with Preserved Aortic Root

The paper evaluates the hemodynamic impact of a novel STJ reconstruction in ATAA repair using computational modeling, showing restored sinus vortices post-surgery.

Synthetic Poly(2-Oxazoline) Chimera 'Lipo-Polymers' as Replacements for Key Lipids in Lipid Nanoparticles

This paper introduces synthetic polymer-based lipid alternatives for lipid nanoparticles, showing they can replace standard lipids while maintaining transfection activity.

Gut delivery of pentameric GLP-1 using genetically engineered Bacillus subtilis

This paper develops an engineered Bacillus subtilis spore system for sustained gastrointestinal delivery of pentameric GLP-1, showing glucose-lowering and weight-reduction effects in mice.

Integrating Metabolic Networks into Hybrid Bioprocess Models

This paper introduces FBA-Hyb, a hybrid model integrating metabolic networks into bioprocess modeling, achieving higher predictive accuracy and stoichiometric consistency.

Predicting post-TEVAR endoleaks: a pre-operative hemodynamic risk factor from patient-specific Fluid-Structure Interaction simulations

This study uses patient-specific Fluid-Structure Interaction simulations to predict post-TEVAR endoleaks by quantifying hemodynamic drag forces and proposing a risk factor R.

golgi: an open-source graphical platform for image-to-recruitment modeling of peripheral nerve stimulation

golgi provides an open-source platform for modeling peripheral nerve stimulation, enabling image-to-recruitment analysis with a graphical interface and reproducible results.

Microfluidic cultivation enables probiotic growth under thermal stress

This study demonstrates a microfluidic platform that enables probiotic bacteria to grow under thermal stress by creating tailored thermal environments.

Function-preserving CD8⁺ T Cell Immunogenicity minimization through protein design

The paper develops a computational framework to minimize CD8⁺ T cell immunogenicity in designed proteins while preserving function, using a de novo luciferase as a model.

An Innervated and Vascularized HNSCC-on-a-Chip Model Built on Defined and Tunable Engineered Extracellular Matrices

This paper develops an HNSCC-on-a-chip model with tunable engineered extracellular matrices, vasculature, and innervation to study tumor behavior and therapeutic responses.

Extending Musculoskeletal Modelling Validation Beyond Gait: Knee Loading and Kinematics During Daily Activities

This study validates musculoskeletal models across daily activities, finding good agreement in knee forces but discrepancies in kinematics and EMG during stair descent.

Tunable Magnetorheological Elastomer Substrates for Studying Mechano-Genetic Interactions in Hypertrophic Cardiomyopathy

This study uses tunable magnetorheological elastomer substrates to investigate mechano-genetic interactions in HCM by applying dynamic mechanical stress to hiPSC-derived cardiomyocytes with a MYBPC3 mutation.

High-Throughput FRET Affinity Screening Technique (HTFAST) For Cell-Free Expressed Binding Protein Characterization

HTFAST enables high-throughput, quantitative affinity measurement of cell-free expressed binders using FRET, validated with nanobodies and SARS-CoV-2 sdAbs.

Marrow-mimicry MEW scaffolds recapitulate erythroblastic islands for high-density cRBC biomanufacturing

This study develops marrow-mimic scaffolds that enhance cRBC production by supporting macrophage-erythroblast interactions in high-density cultures.

BaSiCPy: Scalable and Robust Shading Correction for Optical Microscopy Images

BaSiCPy improves illumination correction in microscopy images by addressing foreground correlations and enabling automated processing.

Computational Design and Evaluation of De Novo Protein Minibinders Targeting Specific Sites of STAT3

The paper designs and evaluates de novo protein minibinders targeting specific STAT3 sites using AI and AlphaFold3, identifying high-confidence binders with novel sequences.

Physiological Oscillations of Lateral Ventricular Volume Revealed by Fast fMRI: Effects of Aging and Vigilance

This study uses fast fMRI to analyze physiological oscillations of lateral ventricular volume in adults, finding age-related ventricular enlargement and increased fluctuation magnitude during drowsiness.