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Hierarchical chromatin polyvalency governs robust gene regulation and organogenesis

The paper shows that H2Aub, not H3K27me3, is the main repressor in chromatin polyvalency, and its disruption causes organogenesis defects in mouse embryos.

Cntnap2 deletion in mice causes developmentally transient alterations in auditory processing and persistent startle hyperreactivity

This study shows that Cntnap2 deletion in mice causes transient auditory brainstem changes and persistent startle hyperreactivity in males, similar to rats but with sex-specific effects.

Analyzing globin gene variation in gnomAD: implications for variant interpretation in hemoglobinopathies

The paper assesses changes in globin gene variant population evidence between gnomAD v2.1.1 and v4.1, showing increased variant discovery and improved ACMG/AMP criterion fulfillment.

Alignment-Free Microhaplotype Genotyping for GT-seq (Genotyping-in-Thousands by Sequencing) Using a Diploid Abundance Model

This paper introduces an alignment-free method for microhaplotype genotyping using GT-seq data, enabling robust inference of diploid genotypes from high-depth amplicon sequencing.

Cryptic diversity in Astyanax (Characiformes: Acestrorhamphidae) from the Magdalena basin, Colombia: Insights from molecular and morphometric evidence

The paper identifies cryptic diversity in Astyanax species from the Magdalena basin using molecular and morphometric analyses, revealing two distinct genetic groups and morphospecies.

Genetic Variation in Organ System Decline Across the Drosophila Genetics Reference Panel

The paper measures age-related organ system decline in 19 Drosophila lines to show genetic variation in physiological decline patterns across genotypes.

An Evolutionarily Conserved Ypk1/SGK1 Kinase Pathway Regulates the Unfolded Protein Response by Modulating the Ire1 Protein Abundance

Elexacaftor/tezacaftor/ivacaftor treatment is associated with epigenetic age deceleration in cystic fibrosis

This study shows that ETI treatment in CF patients reduces epigenetic age acceleration, linked to inflammation and disease activity.

Genome-wide association analysis reveals new loci for leaf water status, biomass and plant architectural traits in bread wheat under rainfed conditions

This study identifies genetic loci associated with drought-related traits in bread wheat using genome-wide association analysis.

How small is too small? Genetic signatures from naturally small populations of a large island vertebrate, the Turks and Caicos Rock Iguana

This study examines genetic diversity and population structure in small island populations of the Turks and Caicos rock iguana, finding low genetic diversity but limited inbreeding and suggesting a low threshold for population persistence.

DiffDomain-Spectrum identifies structurally reorganized TADs from sparse aggregated single-cell Hi-C contact maps

DiffDomain-Spectrum identifies reorganized TADs from sparse aggregated scHi-C maps by analyzing eigenvalue spectra and comparing to a null model, showing higher sensitivity than existing methods.

An ancestral mitochondrial DNA insertion disrupts RNAi and enables persistence of a novel mycovirus in Cryptococcus neoformans

This study identifies a mycovirus, CnTV1, that persists in RNAi-deficient Cryptococcus neoformans isolates due to a NUMT insertion disrupting Ago1, and shows RNAi is critical for viral control.

LAYERED GENOMIC COMPOSITION AND LINGUISTIC CONTINUITY IN GRECIA SALENTINA

The paper uses whole genome sequencing to analyze the genetic structure of a Greek-speaking community in Southern Italy, finding no strong evidence for external origins and supporting a model of continuous gene flow.

Fast and Slow Gene Expression Changes in Blood Following Acute Social Stress

This study identifies fast and slow gene expression changes in human blood after acute social stress, revealing distinct immune cell-related transcriptional responses and potential molecular mechanisms linking stress to psychiatric disorders.

GeneSIS: enhancing transferability of polygenic scores with variant-level gene-by-sex interaction effects

GeneSIS improves polygenic score transferability by incorporating gene-by-sex interactions, enhancing prediction accuracy in non-European populations for 32 traits.

Additive genes contribute to yield heterosis in rice

This study identifies additive genes as key contributors to yield heterosis in rice by analyzing their effects in homozygous and heterozygous backgrounds.

Systematic Engineering of Loss-of-Function Alleles in the Zebrafish Mitochondrial Proteome

The paper generates a systematic in vivo atlas of loss-of-function alleles in zebrafish mitochondrial genes, revealing their impact on bioenergetics and hair cell function.

From Nagelkerke's R2 to Liability-Scale Variance Explained for Polygenic Scores

This paper provides a new method to directly transform logistic regression results to liability-scale variance explained for polygenic scores, validated by simulation.

A mycovirus identified from an outbreak fungal species complex reveals a parallel antiviral system

The paper identifies a mycovirus in the Cryptococcus gattii species complex and reveals parallel antiviral mechanisms involving RNAi and a novel RNase III gene.

Human-specific remodeling of an endogenous retrovirus shapes structural diversity at acrocentric nucleolar organizer regions

The paper reconstructs the evolution of a human-specific endogenous retrovirus, K111, showing its role in shaping structural diversity at acrocentric nucleolar organizer regions through parental transmission and remodeling.