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The paper uses a novel transgenic reporter to study epigenetic reprogramming during zebrafish fin regeneration, identifying early chromatin remodeling events and key factors required for regeneration.

The paper develops a protein structure-based homology search pipeline to annotate kinetoplastid proteins, identifying 23,000 hypothetical proteins and uncovering previously undetected eukaryotic proteins.

The paper compares snRNA-seq data across species to identify cellular differences in the striatum, finding novel interneuron types in bats and differences in neuron-to-glia ratios between primates and non-primates.

CArP uses capture-based long-read sequencing to detect pathogens and AMR genes in complex samples, outperforming traditional methods in sensitivity.

This study investigates the role of alms1 in zebrafish, showing its impact on immune response and brain ageing through transcriptomic analysis and CRISPR/Cas9 depletion.

Azurify classifies somatic variants' clinical significance using machine learning and integrates with clinical data, achieving high accuracy in external validation.

This study evaluates alignment-free methods for viral sequence classification, showing high accuracy and efficiency on SARS-CoV-2, dengue, and HIV datasets.

This study analyzes genome rearrangements in chitons, revealing dynamic genomic changes despite morphological conservatism.

The paper shows that key pluripotency TFs exhibit bimodal DNA binding preferences based on GC-content and STRs, while c-Myc binding is dominated by GC-content and STRs in high-GC regions.

This study reveals the nonrandom 3D genomic organization of Trypanosoma cruzi nuclei through Hi-C data analysis, showing repetitive DNA and noncoding RNA influence chromatin structure and gene regulation.

The paper reports a high-quality haplotype-resolved genome assembly of a cassava line resistant to cassava brown streak disease, revealing structural variations linked to resistance.

The paper evaluates allele age estimators on whole exome datasets and finds a moderate performance decrease compared to whole genome data.

This study uses target enrichment sequencing to assess viral load and diversity in wildlife samples, showing a log-linear relationship between spike-in concentration and read depth.

The paper quantifies cell type-specific epigenomic variation in human breast epithelial cells and links it to genetic variants, showing most regulatory variants act in a single cell type.

The paper identifies an epigenetic signature associated with persister tumor cells in ovarian cancer that correlates with chemotherapy resistance and defines the persister state.

The paper analyzes the evolution and prevalence of dhfr and dhps resistance alleles and haplotypes across Africa using whole genome data from multiple countries.

The paper maps DNA binding and regulatory targets for nearly all yeast transcription factors, revealing that TF binding does not always correlate with gene regulation and many TFs have dual functions.

The paper analyzes defense systems in multidrug-resistant Klebsiella pneumoniae strains from Ghanaian hospitals, identifying CRISPR-Cas, restriction-modification, and toxin-antitoxin systems.

This study identifies a QTL and associated polymorphisms conferring resistance to alpha-cypermethrin in Anopheles funestus using genetic crosses and BSA mapping.