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This study examines how RAGE signaling and Type 2 Diabetes affect cortical bone mechanics, structure, and material properties in mice, showing sex-specific improvements with RAGE ablation.

This study identifies an aberrant FAP subpopulation in VML that drives fibrosis and presents potential targets for scarless muscle regeneration.

The paper uses volumetric imaging and single-cell RNAseq to study human dental pulp responses during tooth decay, identifying cellular mechanisms and progression stages.

This study tracks liver disease progression in PEX1-G844D mice, identifying peroxisomal dysfunction and metabolic changes that contribute to hepatosteatosis, inflammation, fibrosis, and cancer.

The paper identifies 2,3-linked sialic acids in the mammary glands of pregnant dairy heifers, suggesting susceptibility to H5N1 influenza virus infection.

This study identifies two distinct cell proliferation populations during liver regeneration in mice with acute liver injury using single-cell RNA-seq.

This study identifies TRPV4 as a cellular stiffness sensor linking matrix stiffness and atherosclerosis using human tissues and a mouse model.

Across nine Kenyan counties, Stomoxys flies fed on 15 vertebrate hosts, carried Anaplasma, Theileria/Babesia and Trypanosoma DNA, and transmitted T. vivax, T. evansi and Theileria mutans to mice.

This study uses PET imaging to show a strong positive correlation between mGluR5 and synaptic density in early AD patients and cognitively normal individuals, suggesting mGluR5 may mediate early synaptic loss in AD.

This study shows that bone pain in Fibrous dysplasia is intrinsic and not caused by abnormal sensory nerve sprouting or neuroma formation.

This study shows that Alzheimer's disease mice exhibit age-dependent, odorant-specific changes in olfactory sensitivity, with hyperosmia to esters at 2 months and hyposmia at 4 months.

This study shows LOX promotes actin-dependent neutrophil activation and cytotoxicity in diabetes, contributing to diabetic retinopathy through F-actin remodeling and granule clustering.

This study shows that VPS34-driven autophagy restricts cancer initiation by preventing transdifferentiation and reducing oncogenic KRAS promotion in pancreatic acinar cells.

This study shows that Dnmt3a mutations in clonal hematopoiesis drive metabolic diseases like obesity and diabetes in mice, especially under high-fat diet.

This study shows that silencing KRIT1 in endothelial cells under disturbed flow restores KLF2 and KLF4 expression, mimicking the transcriptomic profile of cells under laminar flow.

This study evaluates InstaPRESERVE Tissuesafe as an alternative to formalin for tissue fixation, showing comparable histology quality and reduced processing time.

This paper harmonizes TUNEL with multiplexed immunofluorescence to improve spatial contextualization of cell death in tissues.

This study shows that KUS121 reduces atherosclerosis by maintaining ATP levels and reducing ER stress in endothelial cells.

Cholesterol accumulation in hepatic lipid droplets drives inflammation and fibrosis in mouse and human MASH and is reversed by inhibiting cholesterol synthesis or knocking down Coasy or Hsd17b13.

This paper introduces an automated pipeline to quantify elastic fiber architecture in mouse aorta histology, enabling objective, high-throughput analysis of vascular structure.