C. Zhu

Mutations in the auxin importer gene Spp1/SvAUX1 reveal broad developmental effects in shoots, inflorescences, and flowers, with non-redundant roles among AUX1 homologs.

The paper identifies an AP-3-dependent pathway in yeast leading to vacuole membrane permeabilization and cell death, conserved in Cryptococcus neoformans.

The paper identifies lncEry, a long non-coding RNA that regulates mouse erythroid differentiation and maturation by interacting with WDR82 to control Klf1 and globin gene transcription.

The paper develops a classifier for DCIS recurrence using genomic data from two cohorts and identifies pathways and stroma-specific signatures associated with progression to invasive cancer.

The paper investigates how specific lignin chemistries in different vascular cell morphotypes affect biomechanics and water conduction, showing that changes in lignin composition alter cell wall properties and resilience to environmental stress.

This paper develops an artificial cytosol system using agarose-sucrose to create pH-sensitive liposomes that enhance drug delivery efficiency.

This paper develops an intranasal ASO therapy targeting SARS-CoV-2 RNA that effectively prevents viral replication in multiple models and variants.

This study evaluates a recombinant trimeric Spike protein vaccine with PIKA adjuvant, showing high neutralizing antibody titers and efficacy against COVID-19.

This study shows that combining glucose metabolism inhibition with MEK inhibition enhances apoptosis in pancreatic cancer cells by inducing ER stress.

The paper analyzes tumor microenvironment changes from normal to invasive breast cancer using imaging and machine learning, finding coordinated shifts in stromal cell location and function.

This study characterizes the dynamic changes in B-cell receptor repertoires of COVID-19 patients using next-generation sequencing, revealing clonotype overlap, lineage expansion, and V gene usage patterns.

This study establishes a mouse model of renal cell carcinoma showing that 9p21 loss drives aggressive tumor evolution with chromosomal instability and metastasis.

This study develops an in vivo optical imaging method to quantify long-chain fatty acid uptake in breast cancer models, showing reduced uptake with MYC downregulation and increased uptake with tumor aggressiveness.

This study evaluates the cardiac effects of azithromycin and hydroxychloroquine plus azithromycin in guinea pigs, finding QT interval prolongation and cardiac dysfunction with both treatments.

This study shows allantoin induces pruritus in CKD by activating MrgprD and TRPV1 in DRG neurons.

This study identifies structural variants in Brassica oleracea genomes that contribute to morphological divergence between cauliflower and cabbage.

This study identifies phosphorylated residues in RBM20, showing their role in splicing control and protein shuttling, and links their mutation to cardiac dysfunction.

This paper shows how Begomovirus uses a phosphatase to suppress plant immunity, enhancing virus transmission by herbivore vectors.

The study introduces a new PET radiotracer for profiling tumor protein oxidation as a prognostic indicator of resistance to radiation therapy.

This study shows Carmofur inhibits SARS-CoV-2 main protease by covalently binding to Cys145 and occupying the S2 subsite, with an EC50 of 24.30 M in cell-based viral replication assays.

The paper identifies core transcription factors regulating root growth in soybean under water deficit by integrating phylogenetic analysis and transcriptome data.

The paper reports the cryo-EM structure of 2019-nCoV RdRp complexed with cofactors, revealing key residues and remdesivir binding, aiding antiviral drug design.

The paper presents structures of the expressome in different states to elucidate mechanisms of transcription-translation coupling and collision in bacteria.

The paper compares fecal microbial compositions between female osteoporotic patients and healthy controls, identifying bacterial taxa associated with osteoporosis and demonstrating predictive power using a random forest model.

This study shows FRA1 modulates CMU proteins' cortical microtubule localization, affecting cellulose and matrix polysaccharide deposition in Arabidopsis.

This study identifies YAP1 as a context-specific driver for the squamous subtype of pancreatic ductal adenocarcinoma and shows WNT5A promotes tumor progression through YAP1 activation.

This study shows reticulon and CLIMP-63 regulate nanodomain organization and dynamics of peripheral ER tubules through STED microscopy and live imaging.

This study shows that an early nitric oxide burst mediated by nitric oxide synthase in ammonium-supplied rice roots reduces drought-induced oxidative damage by enhancing antioxidant defenses.

This study shows that NAD(P)HX repair deficiency in yeast and human cells causes metabolic perturbations, including NADHX accumulation, NAD+ depletion, and impaired mitochondrial function.