H. Chen

This study shows that the B.1.1.7 SARS-CoV-2 variant replicates and sheds more efficiently in hamsters' nasal cavities than earlier D614G variants with lower doses and shorter exposure.

The paper analyzes the genome of the estuarine oyster to show how climate history and physical forces shape genomic diversity and adaptive plasticity through gene expansion and regulatory selection.

The paper identifies a novel subtype of therapy-induced prostate cancer cells with hybrid E/M and stem-like traits, showing their dependency on HER2/3 signaling and resistance to AR inhibition.

This study identifies NPR1 and EDS1 as interacting coactivators that synergistically activate PR genes and plant defenses through Mediator complex recruitment and mutual stabilization.

This study investigates the role of EHHADH in DCA β-oxidation and its impact on hepatic cholesterol homeostasis in mice, finding that EHHADH deficiency leads to 3-hydroxydicarboxylic aciduria and altered cholesterol synthesis.

This study shows that SARS-CoV-2 vaccines induce neutralizing antibodies against SARS-CoV-1, SARS-CoV-2, and batCoVs in monkeys.

This study integrates plasma proteomics and single-cell immune features to classify COVID-19 severity and identify biological signatures of disease progression.

The paper calculates the mechanical energy required to cyclize a DNA origami tile with an inherent twist using molecular dynamics simulations.

This study develops a functionalized ECM scaffold with LXW7-DS-SILY to enhance neovascularization and diabetic wound healing in ZDF rats.

This study identifies altered gene expression and cell interactions in oocytes and cumulus cells of PCOS patients, highlighting dysregulated microtubule genes and transposable elements.

This study tracks the global spread of the carbapenem resistance gene blaNDM by analyzing genomic contexts and mobile genetic elements across 6000 bacterial genomes.

The paper analyzes single-cell transcriptomes during liver transplantation to understand ischemia-reperfusion injury and identifies a protective role for TNIP3 in Kupffer cells.

This study isolates and characterizes testicular extracellular vesicles, identifies their cargo, and shows their role in inter-compartmental communication during spermatogenesis.

This study maps the cellular dynamics and intercellular interactions in a mouse liver transplant model using single-cell RNA sequencing and CyTOF, revealing recipient cell dominance and macrophage-driven metabolic remodeling.

The paper investigates how CRISPR-Cas systems in prokaryotes may cause autoimmunity through cross-reactive spacer targeting, revealing a scaling relationship between spacer length and CRISPR repertoire size.

The paper identifies proinflammatory gut microbiome features in SLE patients through metagenomic analysis and shows potential autoimmunogenic mechanisms.

This study introduces a multi-enzyme directed evolution model to improve screening throughput and efficiency, revealing convergent evolution in two cytochrome P450 enzymes with distinct active sites achieving similar functions.

This study shows that the tomato NLR Sw-5b acts in both cytoplasm and nucleus to provide full resistance against tospovirus by blocking different infection stages.

This study evaluates DHEA extract from sweet potato on C. elegans lifespan, finding it extends life by 13.60% but not via calorie restriction, and suggests antioxidant and daf-16 activation mechanisms.

The paper introduces REPOST, a framework predicting potential virus hosts by analyzing receptor orthologs, achieving 95.74% accuracy for SARS-CoV-2.

This paper reports the discovery of a first-in-class, highly selective allosteric inhibitor of PRMT6, SGC6870, with potent activity and selectivity in vitro and in cells.

This study identifies PCSK9 as a target to enhance CD8+ T cell antitumor activity by modulating LDLR and TCR signaling in the tumor microenvironment.

The paper identifies two independent parental contributions to zygote polarization in Arabidopsis thaliana, involving maternal ERECTA and paternal SHORT SUSPENSOR (SSP) in activating the YDA MAP kinase pathway.

The paper identifies key host and viral RNA-binding proteins involved in SARS-CoV-2 infection and shows that drugs targeting these proteins can inhibit infection.

The paper investigates how Type I PRMTs and PRMT5 regulate splicing by analyzing transcriptomic changes and co-transcriptional splicing kinetics.

The paper analyzes public data to show that PDCD1 and CD274 expression in T cells and macrophages correlates with COVID-19 severity.

This paper evaluates the antiviral efficacy of GS441524 and GC376 combination therapy against SARS-CoV-2 in a mouse model, showing synergistic effects and protection with low-dose combined treatment.

This study establishes a comprehensive FcγR reporter cell assay to detect and quantify soluble immune complexes in experimental and clinical settings.

This study evaluates the cardiac effects of azithromycin and hydroxychloroquine plus azithromycin in guinea pigs, finding QT interval prolongation and cardiac dysfunction with both treatments.