H. Wang

This study develops an immunocytokine (LH01) combining anti-PD-L1 and IL-15 to enhance antitumor immunity and overcome resistance to PD-L1 blockade in mouse models.

This paper introduces DeepCAD-RT, a real-time denoising method for fluorescence time-lapse imaging that improves signal-to-noise ratio with fewer photons, demonstrated across multiple organisms and biological processes.

This study identifies critical ecological protection areas in Aksu City and Wensu County by simulating human activity impacts and analyzing resistance surfaces across different scenarios.

This study identifies SOX4 as a critical regulator of human endometrial decidualization by modulating PGR stability and FOXO1 expression, linking its dysregulation to infertility and pregnancy complications.

This study develops a chimeric mRNA vaccine that provides broad protection against Omicron and Delta variants of SARS-CoV-2 by combining RBDs from different variants.

The paper identifies two isomers of Safranin O in commercial preparations and characterizes their electrochemical and photophysical properties.

This study investigates the anaerobic biodegradation of chloroform and dichloromethane using a microbial enrichment culture, finding that oxidation of dichloromethane supports further dechlorination of chloroform.

This study identifies a unique phosphonate utilization mechanism in diatom Phaeodactylum tricornutum involving uptake via clathrin-mediated endocytosis and incorporation into membrane phospholipids.

This paper develops an mRNA vaccine targeting the Omicron variant's RBD, showing it induces Omicron-specific neutralizing antibodies but not against wildtype or Delta strains.

The paper shows fish oil nano-emulsions trigger ferroptosis and autophagy in macrophages via catalase-catalyzed superoxide production, leading to oxidative damage.

The paper analyzes VDR genomic interactions in African American prostate cancer cells and identifies BAZ1A as a regulator of VDR-dependent transcriptional responses.

This study evaluates the effectiveness of various vaccine boosters against the Omicron variant following prime vaccinations with inactivated or adenovirus-vectored vaccines, finding that certain boosters significantly enhance neutralizing activity.

This study shows Harringtonine inhibits SARS-CoV-2 membrane fusion by targeting both the viral S protein and host TMPRSS2, effectively blocking infection in delta and Omicron variants.

This study maps chromatin reprogramming and transcriptional regulation during hexaploid wheat embryogenesis, revealing epigenetic mechanisms governing cell fate and organogenesis.

This study uses nuclear and plastid sequences to reconstruct the phylogeny of Diabelia, revealing hybridization, divergence times, and biogeographic patterns in the Sino-Japanese region.

A human antibody, VacW-209, broadly neutralizes SARS-CoV-2 variants including Omicron by targeting a conserved epitope, highlighting the importance of such antibodies in pandemic control.

The paper identifies the AlgU sigma factor regulon in planta and shows its overlap with PTI-regulated genes in Pseudomonas syringae pv. tomato DC3000.

This study uses single-molecule fluorescence microscopy to show that stable 5'UTR hairpins reduce 60S recruitment and translation efficiency by destabilizing 40S-mRNA interactions.

This study investigates how m7G cap-eIF4E interactions influence polysome formation kinetics using single-molecule tracking in wheat germ and HeLa extracts.

This study shows TXNRD3 is essential for male fertility by regulating redox balance during spermatogenesis, as demonstrated through knockout mice and proteomic analysis.

This study presents a droplet microfluidic assay to assess CAR-T cytotoxicity in vitro, enabling analysis of activity, expansion, and mechanism under varying conditions.

This study compares immune responses between BioNTech and Sinovac vaccines in Hong Kong, finding Sinovac induces lower neutralizing antibodies and wanes faster against SARS-CoV-2 variants.

This study identifies THEMIS as a substrate of SHP1 and shows it has phosphorylation-dependent and -independent roles in T cell development.

This study maps 3D genome reorganization during skeletal muscle stem cell activation, proliferation, and aging using Hi-C, revealing how chromatin architecture influences gene expression and lineage progression.

This study identifies REPTOR/CREBRF as key regulators of muscle energy metabolism, showing they repress glycolysis and promote oxidative phosphorylation in both flies and mammals.

This study uses single-cell RNA-sequencing to analyze immune cell diversity across 12 species, revealing conserved and divergent molecular mechanisms and cellular interactions.

The paper systematically simulates interactions of 100 mammalian PH domains with PIP-containing membranes, revealing conserved and novel interaction sites and mechanisms.

This study compares the structural and signaling differences between two μOR agonists, lofentanil and mitragynine pseudoindoxyl, revealing how their distinct binding modes lead to different G protein and β-arrestin activation profiles.

This study shows that a specific static magnetic field reduces oxidative stress and liver damage caused by alcohol consumption in mice.

This paper develops a computational model to predict immune synapse formation for TCEs in multiple myeloma, showing similar immune synapse numbers between two clinical TCEs at their efficacious doses.