J. Zhu

The paper presents the cryo-EM structure of the human SIRT6-nucleosome complex, revealing how SIRT6 deacetylates histone H3 K9 and K56.

This study shows that vaccinating with mycobacterial lipid-loaded nanoparticles induces persistent lipid antigen presence and memory T cell differentiation in mice.

This study identifies glycerophospholipid metabolism as a key factor in rheumatoid arthritis development through multi-omics analysis of gut microbiota, metabolites, and gene expression.

This study uses a genetic system to screen essential proteins in Mycobacterium smegmatis, identifying labile targets for PROTACs and showing their potential to enhance antibiotic efficacy.

This study shows stroke triggers inflammasome-dependent atherosclerotic plaque rupture, leading to recurrent stroke, and identifies DNA-mediated inflammasome activation as a therapeutic target.

This study reports the structures of C3a-bound C3aR and C5a-bound C5aR1, revealing their ligand recognition and activation mechanisms.

This study shows that tryptophan depletion increases AHR expression and kynurenine uptake, enhancing AHR activation and promoting regulatory T cell differentiation.

This study identifies the MTORC1-AHR pathway as a mechanism sustaining translation and autophagy in tumors under tryptophan stress by enhancing AHR activity and autophagy regulators.

This study identifies HERC5-catalyzed ISGylation of cGAS as a mechanism that enhances antiviral innate immunity by modulating the cGAS-STING pathway.

This study shows FAM76B inhibits NF-κB-mediated inflammation by affecting hnRNPA2B1 translocation in vitro and in a TBI mouse model, and identifies its interaction with hnRNPA2B1 in human TBI and neurodegenerative disease tissues.

The paper investigates drug resistance in Klebsiella pneumoniae, finding that rcsB regulates capsule formation, which affects drug resistance.

This study generates insulin-secreting organoids from human gastric stem cells that restore glucose homeostasis in diabetic mice.

This study shows that KDM5A/B promote HIV-1 latency and their inhibition with JQKD82, combined with AZD5582, reactivates HIV-1 and induces cell death.

The paper develops Cu-tRNAseq to study peptidyl tRNA turnover in Mtb, finding Pth is essential for prolyl-tRNA recycling and identifies Pth as a potential TB therapeutic target.

This paper uses molecular dynamics simulations to study how small molecules bind to the disordered AR-NTD, revealing structural mechanisms that explain their potency and provide insights for drug design.

This study evaluates the impact of Fcγ receptor affinity on CAR T cell efficacy and safety, finding that moderate affinity provides optimal antitumor activity while high affinity causes toxicity.

The paper profiles single-cell RNA sequencing data from Arabidopsis infected with Pseudomonas syringae to identify immune and susceptible cell clusters and their transcriptional responses.

This study evaluates the antiviral breadth of monoclonal and bispecific antibody cocktails against SARS-CoV-2 variants using a replication competent VSV-SARS-CoV-2 model, showing resistance to mutation in two cocktails.

This study identifies conserved cold-responsive regulators and their regulatory networks across three rosid species, revealing a hierarchical control involving circadian components.

This paper identifies key parameters and stages for all-aqueous printing of viscoelastic droplets in yield-stress fluids, providing a framework for precise 3D bioprinting.

This study optimizes a small molecule inhibitor targeting the aromatic-rich activation domain of the androgen receptor, showing improved affinity and antitumorigenic effects in prostate cancer models.

This study shows that cell surface excess (CSE) is crucial for protrusions and motility in 3D collagen matrices, with microtubules regulating its storage and release.

This study shows that mitochondrial dysfunction triggers a retrograde signaling program that reduces cellular maturity in metabolic tissues, and blocking this signaling can restore cell identity and improve hyperglycemia.

This study shows YAP suppresses AR-driven prostate cancer growth by blocking TEAD-mediated AR signaling through competitive binding.

This study shows porcine STING has antiviral activity independent of IFN and autophagy, and also triggers apoptosis to resist viral infections.

The paper identifies inhibitors of DNA sensors like AIM2, cGAS, and TLR9, including 4-sulfonic calixarenes and suramin, showing potential for treating DNA-driven inflammatory diseases.

This study examines age-related seroprevalence of four seasonal coronaviruses in children and postpartum women, showing waning passive immunity and resurgence of IgGs with age.

This study identifies TWD1 as an ER-actin adapter that links myosin XI-K to auxin transport, explaining defects in ABCB biogenesis and plant development.

This study identifies ZmEREB57 as a maize AP2/ERF transcription factor that enhances salt stress tolerance by regulating OPDA and JA signaling through two distinct pathways.

Glycan trimming of HIV-1 Env immunogens improves vaccine-induced neutralizing antibody responses in small animals and primates.