L. Wang

The paper identifies dysfunctional CD8 CAR T-cells in rrLBCL tumors and shows that pegenzileukin mitigates this dysfunction, improving CAR T-cell responses.

This paper shows that ubiquitin stabilizes Eps15 condensates, which are essential for clathrin-mediated endocytosis, and that ubiquitylation regulates the dynamics of endocytic assemblies.

This study shows that SNHG16 promotes paclitaxel resistance in breast cancer by suppressing Let-7a-5p and upregulating DUSP7, suggesting the SNHG16-Let-7a-5p-DUSP7 axis as a potential therapeutic target.

The paper analyzes the virological characteristics of the SARS-CoV-2 XBB.1.5 variant, showing reduced pathogenicity and impaired MHC expression due to mutations in ORF8 and S.

This study compares a novel VZV mRNA vaccine (ZOSAL) with Shingrix in mice and rhesus macaques, showing ZOSAL induces stronger T cell immunity and safety.

The study shows that HDAC6's role in inflammasome formation varies depending on the cellular context and model system used.

This paper develops a PROTAC molecule (NR-V04) that degrades NR4A1, leading to tumor inhibition and immune modulation in melanoma.

This study shows that fibronectin promotes stronger stiffness-dependent responses in human myoblasts compared to laminin and collagen, with softer substrates increasing nuclear wrinkling linked to proliferation.

This study identifies CDK8 and CDK19 as drivers of androgen-independent growth in castration-resistant prostate cancer and shows that their inhibition can suppress tumor growth and induce regression.

This paper introduces a method to rapidly and efficiently isolate extracellular vesicles with high purity and recovery, enabling downstream analyses for cancer diagnostics.

This paper develops a method to combine single-cell X-ray tomography and fluorescence imaging to study cellular structures and chemical element distributions.

This study identifies BrrRCO, a HD-Zip transcription factor, as a key gene regulating leaf lobe development in Brassica rapa, with cis-regulatory variations affecting its function and leaf shape.

This paper develops a small-molecule approach to detect reactive inorganic targets using pre-ligands and the Baby Spinach aptamer, bypassing in vitro selection and enabling cell-based sensing.

The paper shows O-GlcNAcylation of Keratin 18 coordinates TCA cycle enzymes to promote cholangiocarcinoma progression by stabilizing K18 and altering metabolite levels.

This study identifies distinct roles of MSH2 and MLH1 in basal-like breast cancer, showing MSH2 promotes metastasis while MLH1 enhances it, and reveals MSH2's role in immune modulation through IFNAR1 regulation.

This study identifies HSPB1 as a driver of chemoresistance in breast cancer by inhibiting ferroptosis and activating NF-κB signaling.

This study shows that intrinsically disordered proteins can undergo phase separation on lipid droplet surfaces, forming liquid-like protein-rich phases.

The paper describes CyVerse, an open-source cyberinfrastructure platform for life sciences, and outlines a strategic blueprint for managing SaaS and IaC as free and open-source software.

This study identifies TARBP1 as a driver gene in hepatocellular carcinoma that promotes tumor progression by methylating tRNA and enhancing glutamine metabolism.

The paper shows that the potato resistance gene RB uses alternative splicing to balance growth and immunity, with the pathogen effector IPI-O1 promoting splicing to enhance immunity.

This study identifies CD301+ macrophages as drivers of endometrial fibrosis and infertility, showing their inhibition improves pregnancy outcomes in mice.

This paper introduces a new method for isolating and transforming passion fruit protoplasts, achieving high yield and transfection efficiency for transient gene expression.

CytoSIP provides a database of cytokine-cytokine receptor interactions with SNPs, interfaces, and disease associations to aid drug design and precision medicine.

This study develops a genetically encoded redox-responsive collagen-like protein hydrogel that accelerates diabetic wound healing by enhancing cell viability and reducing oxidant stress.

This study identifies GTPBP8 as a critical factor for mitoribosomal assembly and mitochondrial translation, showing its depletion impairs subunit maturation and function.

This study shows Ikaros is essential for Treg function by cooperating with Foxp3 to regulate gene expression and suppress inflammation.

This study shows that prolonged exposure to herbivore-induced volatiles causes neighboring plants to exhibit a clocked temporal response, integrating priming and direct induction.

The study assesses vector competence of Belgian Culex mosquitoes for West Nile and Usutu viruses, finding Culex pipiens pipiens transmits WNV but not USUV, while Culex modestus transmits USUV but not WNV, with Wolbachia presence species-specific.

The paper identifies the AMP deaminase from Helix pomatia as a member of the ADGF family despite its preference for AMP over adenosine.

This study shows that combining bacteriophage Remus and vancomycin effectively reduces MRSA biofilm-like aggregates in both in vitro and in vivo models.