S. Lee

This study uses molecular dynamics simulations to show that GPCR activation in cell membranes involves microswitches and is regulated by PIP2 and calcium ions, differing from detergent environments.

This study shows that coronin 1a is required for M cell uptake and transcytosis of pathogens in human ileal enteroids, but not commensal bacteria.

This study shows that antibodies from early SARS-CoV-2 infections neutralize both the original and D614G variants, though neutralizing capacity decreases over time.

This study identifies QTL and candidate genes for flavor compounds in strawberry using multi-omics analyses, revealing novel genes and pathways involved in volatile compound biosynthesis.

This paper introduces a data-driven method for multiplexed microtomography using refractive index imaging to study endogenous subcellular dynamics without exogenous labels.

The paper develops deep learning models using RNA-seq data that incorporate isoform and exon information to improve smoking status prediction, achieving higher AUC than gene-level models.

This study shows that poly-PR and poly-GR DPR proteins inhibit ribosome peptidyl-transferase activity by blocking the polypeptide tunnel, as revealed by cryo-EM structures.

This study uses a Cd300lf conditional knockout mouse to show that CD300lf on tuft cells is essential for persistent MNoVCR6 infection, while myelomonocytic cells are major targets for non-persistent MNoVCW3, with STAT1 restricting its tropism.

This study investigates how cell geometry affects growth, chromosome segregation, and division in Bacillus subtilis L-forms, showing that surface area over volume and nucleoid positioning are key factors.

This paper introduces COSI, a label-free imaging method to quantify intra-thrombus mass and adhesive platelet dynamics under fluid shear stress with high precision.

This study investigates the role of ESR1-CCDC170 gene fusions in breast cancer endocrine resistance, showing they reduce endocrine sensitivity and can be targeted with HER2/SRC inhibitors.

This paper develops a long-term vagus nerve stimulation implant in mice and demonstrates its effectiveness in reducing inflammation over 4 weeks.

This study identifies MYB10 allelic variation as the primary driver of natural color variation in strawberry fruit, with specific mutations affecting anthocyanin biosynthesis in both diploid and octoploid species.

The paper characterizes SARS-CoV-2-specific T cells in recovered patients, finding they exhibit robust helper function, reduced terminal differentiation, and high proliferative potential.

This paper introduces Proxy-ResNeXt-CBAM, a metric learning network for chromosome classification and retrieval in karyotyping, achieving high accuracy and effective clustering of embeddings.

The paper develops a multiparametric scoring algorithm to assess the severity of missense mutations in the VHL protein using 285 ClinVar mutations, linking higher scores to pathogenicity.

This study uses live-cell 3D single-molecule tracking to show that the NuRD complex decompacts chromatin and alters enhancer dynamics by increasing their movement and reducing time in a fast-diffusing state.

The paper examines how different cropping systems affect soil fungal and prokaryote community diversity and stability over a growing season in a long-term field trial.

This paper introduces a method to sort single cells based on secreted products using microparticles, enabling high-throughput screening of cell function.

This study demonstrates that ThiL is essential for thiamine biosynthesis and salvage in Pseudomonas aeruginosa and identifies inhibitors with potential antibacterial activity.

This paper identifies and characterizes two distinct developmental forms of Orientia tsutsugamushi, intracellular and extracellular bacteria, showing differences in morphology, protein expression, and entry mechanisms into host cells.

This study identifies SPAs as regulators of thermomorphogenesis in Arabidopsis by modulating the phyB-PIF4 module in response to high temperature.

This study identifies and characterizes MLO gene family in diploid and octoploid strawberry, revealing potential susceptibility sources and eQTL associations with MLO transcript levels.

This study examines VEGFR-2 mobility and organization on endothelial cells, revealing how receptor heterogeneity influences VEGF activation mechanisms.

The paper introduces the Kinase Chemogenomic Set (KCGS), a curated collection of 187 selective kinase inhibitors covering 215 human kinases, for use in cell-based screens.

The paper identifies a novel IKK- and proteasome-independent mechanism of RelA activation in senescent cells that drives the senescence-associated secretome through transcriptional repression of NFKBIA.

This study measures 3-D morphology changes in human red blood cells under localized photothermal effects using gold nanorods and 3D quantitative phase imaging.

This study shows that hepatocytic Prominin-1 prevents liver fibrosis by stabilizing SMAD7, thereby inhibiting TGFβ signaling.

This paper uses 3-D quantitative phase imaging to study platelet activation dynamics, finding that thrombin and TRAP stimulation leads to lower cellular concentration and dry mass compared to resting platelets.

This study compares the microbiomes of three Periplaneta cockroach species using 16S rRNA sequencing, finding similar but distinct bacterial compositions despite shared rearing conditions.