S. Li

The paper identifies specific gyrA gene mutations in Mycobacterium tuberculosis isolates that cause discordant levofloxacin resistance between molecular and phenotypic testing.

The paper determines the crystal structure of a keratin 5 and 14 2B domain complex and identifies key interactions critical for intermediate filament assembly.

The paper identifies RosA, a sponge RNA in Bacillus subtilis, which regulates RoxS and FsrA sRNAs, linking carbon metabolism regulators to post-transcriptional control.

This paper introduces amino and PEG-amino functionalized graphene oxide grids to improve sample concentration, distribution, and protection for cryo-EM.

The paper tests the reproducibility of PDX drug responses and sequence results across different labs using standardized protocols and workflows.

This study examines changes in IL-10 expression in myocardial infarction and its association with macrophage activation and cardiomyocyte apoptosis over time.

The paper identifies peTrpL as a conserved bacterial leader peptide that, along with rnTrpL, mediates tetracycline-dependent destabilization of ribosomal protein mRNAs.

This study shows CpG-ODN 2007 reduces mortality and toxicity in zebrafish infected with Vibrio vulnificus and modulates immune gene expression.

The paper tests metagenomic sequencing with ONT MinION for strain-level identification of bacterial tomato pathogens, achieving success with Pto but showing challenges with field samples.

The paper develops a method to generate diverse peptide libraries in mammalian cells using an ldsDNA-based AND gate genetic circuit, demonstrating sequence and length diversity through HTS and identifying an MDM2-interacting peptide.

This study compares the gut microbiome of short-term and long-term medical workers to normal controls, finding significant structural changes linked to hospital exposure.

This paper develops a method to study clonal responses to chemotherapy in CLL by combining barcoding with single-cell RNA sequencing, revealing that rare drug-tolerant clones dominate post-treatment populations.

This paper establishes a novel human HCC patient-derived xenograft model in immunocompetent mice, showing high tumor formation rates and preserved tumor characteristics.

This study identifies arginine-GlcNAcylation as a mechanism by which bacterial effectors NleB and SseKs modulate host death receptor signaling to promote pathogenesis.

The paper identifies dysbiosis in RA tonsillar microbiota and shows that Streptococcus salivarius and its antibacterial peptides modulate autoimmunity by suppressing T cells and autoantibodies.

The paper introduces Q-scores to quantify atom resolvability in cryoEM maps and validates their reproducibility across different labs.

Ribosolve rapidly determines 3D RNA-only structures using cryo-EM, chemical mapping, and Rosetta modeling, validated by multiple benchmarks and showing high accuracy.

This study reports the absence of PD-1 expression on EBV-specific CD8+ T cells in LELC, suggesting anti-PD1/PD-L1 therapy may not be effective for this cancer type.

The paper investigates the role of CSI1 and microtubules in cell wall architecture during acid growth in Arabidopsis hypocotyls, finding that CSI1-dependent crossed-polylamellate walls are essential for auxin-induced cell elongation.

This study shows CD155/CD96 promotes immunosuppression in LUAD by inhibiting antitumor immune responses and up-regulating CD96 in CD8 T cells, with potential therapeutic implications.

This study shows that glutathione (GSH) is necessary for efficient post-Golgi trafficking of HPV16 genome to the nucleus.

This study investigates the nonreciprocal and conditional cooperativity between Sox2 and Oct4 in nucleosome targeting using single-molecule fluorescence microscopy.

This study adapts base editors to Streptomyces, achieving high-efficiency genome editing without DNA double-strand breaks.

The paper identifies 28s5-rtsRNA as an abundant rRNA-derived sRNA that regulates ribosomal protein mRNA levels by altering the 28s/18s rRNA ratio.

The paper investigates pre-existing adaptive immune responses to CRISPR Cas proteins and AAVs in non-human primates and finds such immunity is普遍存在 regardless of Cas proteins or AAVs.

This study shows that oscillatory movement of engineered antigen-presenting cells enhances T-cell activation and expands regulatory T cells more effectively than static cultures.

The paper uses electron cryo-tomography to reveal the structure and assembly mechanism of procentrioles in Chlamydomonas reinhardtii, identifying key components and intermediates.

The paper introduces a Nanopore-based sequencing method to rapidly map transgenic alleles in the soybean genome, offering a high-throughput and cost-efficient approach.

This paper elucidates the compartmentalized biosynthetic pathway of mycophenolic acid, revealing subcellular localization of enzymes and cooperation with β-oxidation machinery.

This study identifies SmbHLH37 as an antagonist of SmMYC2 in regulating jasmonate-mediated phenolic acid biosynthesis in Salvia miltiorrhiza.