S. Wang

A maize lipid droplet-associated protein is modulated by a virus to promote viral multiplication and infection

This study shows that rice black streaked dwarf virus recruits a maize lipid droplet-associated protein to regulate fatty acid metabolism, promoting viral multiplication and infection.

SCCA1/SERPINB3 promotes suppressive immune environment via STAT-dependent chemokine production, blunting the therapy-induced T cell responses

This study shows that SCCA1/SERPINB3 promotes an immunosuppressive tumor microenvironment by increasing chemokine production via STAT signaling, reducing T cell responses to radiotherapy.

iTie controls intestinal tolerance through suppressing the NLRP6 inflammasome

This study identifies iTie as a regulator of intestinal tolerance by suppressing the NLRP6 inflammasome, with implications for treating bowel diseases.

Insulin determines the effects of TGF-beta on HNF4alpha transcription and epithelial-to-mesenchymal transition in hepatocytes

This study shows insulin prevents TGF-beta-induced EMT in hepatocytes by inhibiting SMAD2/3 binding to C/EBP and SNAI1 promoters, maintaining HNF4 expression.

Structural insights into transcription activation mechanism of the global regulator GlnR from actinobacteria

This paper reports the crystal and cryo-EM structures of GlnR-DNA and GlnR-TAC complexes, revealing the transcription activation mechanism of GlnR in actinobacteria.

A cinnamyl alcohol dehydrogenase (CAD) like enzyme leads to a branch in the shikonin biosynthetic pathway in Arnebia euchroma

This study identifies AeHGO, a CAD-like enzyme, as the branch point enzyme in the shikonin biosynthetic pathway of A. euchroma, showing it catalyzes reversible oxidation/reduction of key intermediates.

Abnormal expression of Prolyl oligopeptidase (POP) and its catalytic products Ac-SDKP contributes to the ovarian fibrosis change in Polycystic ovary syndrome (PCOS) mice

This study shows that reduced Prolyl oligopeptidase (POP) and its product Ac-SDKP contribute to ovarian fibrosis in PCOS mice by altering MMP-2 and TGF-β1 expression.

MYSM1 co-activates ERα action via histone and non-histone deubiquitination to confer antiestrogen resistance in breast cancer

This study identifies MYSM1 as an ER co-activator that promotes antiestrogen resistance in breast cancer through histone and non-histone deubiquitination.

Elemental diet enriched in amino acids alters gut microbial community and prevents colonic mucus degradation in mice with colitis

This study shows that an amino acid-enriched elemental diet reduces mucolytic bacteria and protects the mucus layer in mice with colitis.

Deep learning-based predictive identification of functional subpopulations of hematopoietic stem cells and multipotent progenitors

This study develops a deep learning model to classify hematopoietic stem cells and multipotent progenitors using light microscopy images, demonstrating its effectiveness in distinguishing functional subpopulations.

Nucleic acid sensing by STING induces an interferon-like antiviral response in a marine invertebrate

This study shows that shrimp STING detects DNA to trigger an interferon-like antiviral response, independent of cGAS and involving the IRF-Vago pathway.

Identification of a key genetic factor governing arabinan utilization in the gut microbiome suggests a novel therapeutic target for constipation

The paper identifies the abfA cluster as a key genetic factor for arabinan utilization in gut microbiota, showing its therapeutic potential for constipation through improved gut motility and metabolite production.

A Deep Learning Approach for Histology-Based Nuclei Segmentation and Tumor Microenvironment Characterization

This study introduces HD-Yolo, a deep learning method for faster and more accurate nuclei segmentation and tumor microenvironment quantification in whole-slide images.

Lineage-mosaic and mutation-patched spike proteins for broad-spectrum COVID-19 vaccine

This study develops a bivalent vaccine using lineage-mosaic and mutation-patched spike proteins that elicit broad-spectrum antibodies and protect against multiple SARS-CoV-2 variants in hamsters.

Proteomic Landscape of Human Spermatozoa: Optimized Extraction Method and Application

This study optimizes protein extraction methods for human sperm and investigates antibiotic effects on sperm proteome, finding increased concentration and malformed sperm with altered proteome expression.

Monkeypox virus quadrivalent mRNA vaccine induces antibody responses and cellular immunity and protects mice against Vaccinia virus

This study develops two quadrivalent mRNA vaccines against monkeypox virus and shows they induce antibodies, cellular immunity, and protection against Vaccinia virus in mice.

A complex evolutionary history of genetic barriers to gene flow in hybridizing warblers

This study investigates genetic barriers to gene flow in hybridizing warblers, identifying long-lasting and recent selective sweeps in specific genomic regions.

RNA sequencing analyses of gene expression by CRISPR/Cas9 knockout of CLL-1 gene in acute myeloid leukemia cells

This study uses CRISPR/Cas9 to knockout CLL-1 in AML cells, identifies differentially expressed genes, and finds hub genes involved in chemokine signaling and ubiquitination.

Control of Clostridiodes difficile virulence and physiology by the flagellin homeostasis checkpoint FliC-FliW-CsrA in the absence of motility

This study investigates the role of the FliC-FliW-CsrA network in C. difficile virulence and physiology, showing that these proteins regulate toxin production and metabolism even in non-motile strains.

Disruption of OsLAT5 is sufficient to endow rice tolerance to dihydropyridine herbicides at commercial application concentrations

This study shows that disrupting OsLAT5 in rice confers tolerance to dihydropyridine herbicides without affecting yield or grain quality.

Evaluation of antibody kinetics and durability in health subjects vaccinated with inactivated COVID-19 vaccine (CoronaVac): A cross-sectional and cohort study in Zhejiang, China

This study evaluates antibody kinetics and durability after CoronaVac vaccination in health subjects, finding waning antibody levels over time and improved responses with a booster dose.

Excited-state dynamics of the all-trans protonated retinal Schiff base in CRABPII-based rhodopsin mimics

This study investigates the excited-state dynamics of the all-trans protonated retinal Schiff base in CRABPII-based rhodopsin mimics using transient absorption and fluorescence spectroscopy, revealing differences in dynamics across mutants and potential applications in bioimaging.

Mutagenesis and structural modeling implicate RME-8 IWN domains as conformational control points

The paper identifies IWN domains in RME-8 as conformational control points that regulate DNAJ domain exposure and function through interactions with SNX-1.

Splicing factor BUD31 promotes ovarian cancer progression through sustaining the expression of anti-apoptotic BCL2L12

This study identifies BUD31 as a splicing factor that promotes ovarian cancer by maintaining anti-apoptotic BCL2L12 expression through exon inclusion.

A germline-targeting chimpanzee SIV envelope glycoprotein elicits a new class of V2-apex directed cross-neutralizing antibodies

This study identifies a new class of V2-directed cross-neutralizing antibodies targeting a cryptic epitope in occluded-open HIV and SIV Env trimers.

Bacterial anomalies in seabed sediments associated with deep water hydrocarbon seepage

This study uses 16S rRNA gene sequencing to identify bacterial anomalies in deep-sea sediments linked to hydrocarbon seepage, finding distinct microbial signatures associated with thermogenic and biogenic hydrocarbons.

Treatment of prostate cancer with CD46 targeted 225Ac alpha particle radioimmunotherapy

This study develops and evaluates [225Ac]DOTA-YS5, a radioimmunotherapy for prostate cancer, showing high efficacy in xenograft models but nephrotoxicity at higher doses.

Long-term passaging of replication competent pseudo-typed SARS-CoV-2 reveals the antiviral breadth of monoclonal and bispecific antibody cocktails

This study evaluates the antiviral breadth of monoclonal and bispecific antibody cocktails against SARS-CoV-2 variants using a replication competent VSV-SARS-CoV-2 model, showing resistance to mutation in two cocktails.

Highly synchronized cortical circuit dynamics mediate spontaneous pain

This study shows that spontaneous pain induces synchronized neural dynamics in the primary somatosensory cortex, and reversing this synchronization alleviates pain.

Integrative multispecies omics reveals a hierarchy of cold-responsive regulatory network launched by circadian components in rosids

This study identifies conserved cold-responsive regulators and their regulatory networks across three rosid species, revealing a hierarchical control involving circadian components.