X. Chen

This study shows AMPK and UPR interact via a positive feedback loop in muscle cells exposed to palmitate, with AMPK agonists enhancing UPR gene expression.

The paper shows that RZ-1 and PRC2 work together to silence NCED6, a gene involved in ABA biosynthesis, which is essential for seed germination in Arabidopsis.

This study shows PBP1 in Staphylococcus aureus has essential roles in cell division through its enzymatic activity and PASTA domains, affecting septum formation and morphology.

This study shows macaque monkeys use strategy-based hierarchical decision-making to play Pac-Man with over 90% accuracy, revealing advanced cognitive capabilities previously unobserved in animals.

This paper introduces Deep-SMV, a deep learning-based method for super-resolution microbubble velocimetry that directly outputs blood velocity maps without requiring microbubble localization.

This study shows that CD147 antibody inhibits SARS-CoV-2 infection and cytokine storm in variants by blocking viral entry and reducing inflammatory responses.

The paper identifies mosaic evolution in multiple beta-barrel porin genes in E. coli, showing local recombination and sequence variation that may help bacteria evade environmental threats.

This study shows that Malus baccata contributes to the genomes of cultivated European and Chinese apples through gene flow, alongside Malus sylvestris and Malus sieversii.

This paper shows that glycosaminoglycans (GAGs) reduce long-range mechanical communication between cells in collagen networks by preventing collagen fiber alignment.

This paper introduces a high throughput single-cell pipeline for bispecific antibody discovery, demonstrating its efficiency in identifying rare functional clones and uncovering design principles for improved immunotherapeutics.

The paper identifies two ubiquitin-activating systems in plants, showing that one E1 plays a major role in plant immunity by differentially charging ERAD-associated E2s for ER stress tolerance.

The paper shows that PFOR supports aerobic photomixotrophic growth in cyanobacteria by utilizing ferredoxin instead of NAD(H), saving Gibbs free energy and decelerating metabolism.

The paper presents the cryo-EM structure of the human TACAN channel in a closed state and identifies key residues and cholesterol interactions involved in its function.

This paper uses micro-CT to study the appendage structure of Pygmaclypeatus daziensis, revealing its heteronomy and suggesting an ancestral exopodite morphology in Artiopoda.

The paper examines S. commune fruiting bodies and hyphae to confirm the presence of calcium oxalate crystallites, demonstrating biomineralization in this fungus.

This study investigates how hyperproteinemia disrupts blood cell homeostasis in an invertebrate model, identifying novel signaling pathways and potential biomarkers.

This study identifies that DENV NS1 and MMP-9 cooperate to induce vascular leakage by altering endothelial cell adhesion and tight junctions, suggesting MMP-9 as a potential therapeutic target for severe dengue.

This study identifies ERAD as a proteostasis checkpoint during β-selection, showing Sel1l deficiency causes ER stress and apoptosis, impairing β T cell development.

The paper identifies membraneless organelles in bacteria that enhance stress tolerance through liquid-liquid phase separation.

This study shows that targeting developmental states in rhabdomyosarcoma can prevent disease recurrence by eliminating myoblast-like cells and inhibiting EGFR-dependent paraxial mesoderm populations.

This study shows that PIK3CA mutations drive hepatocarcinogenesis independently of RASSF1A status, with early Galectin-1 upregulation and synergistic therapeutic effects of PIK3CA and Galectin-1 inhibitors.

This paper reviews preclinical studies showing that inhibiting cholesterol esterification reduces tumour burden across cancers, with SOAT inhibitors like avasimibe showing promise.

The paper identifies IL20RA as a key factor preventing ovarian cancer metastasis through immune crosstalk with peritoneal mesothelial cells.

The paper shows that autocrine TNF-α/TNFRI signaling drives CD4+ T cell lymphopenia and dysfunction in severe COVID-19, and TNF-α blockade improves outcomes.

This paper develops a deep-learning enhanced on-chip DSLM system for high-speed volumetric imaging of neural activity in moving Drosophila larvae.

This study identifies Rnd3 as a protective factor in placental mitochondria through PPARγ-UCP2 signaling, showing its role in mitigating oxidative stress in preeclampsia.

This paper identifies and characterizes a phage-derived depolymerase, Dpo71, which enhances antibiotic efficacy and immune response against multidrug-resistant Acinetobacter baumannii.

The paper shows that microtubules inhibit miR165/6 loading into AGO1 in the cytoplasm, enabling its non-cell autonomous movement in Arabidopsis roots.

This study shows that trimming N-glycans from the SARS-CoV-2 spike protein enhances immune responses and protection against variants in hACE2 mice.

This paper presents a deformable microfluidic device using microbeads to separate plasma and retrieve blood cells, supported by imaging and computational modeling.