X. Li

This study combines computational modeling and experiments to show that hypoxia and RBC aggregation enhance macrophage retention of sickle RBCs, contributing to splenic congestion in SCD.

The paper introduces SPOTIT and SPOTall sensors to detect GPCR agonist localization in the whole brain using fluorescent integrator sensors for multiple neuromodulators.

This study develops a genetically encoded redox-responsive collagen-like protein hydrogel that accelerates diabetic wound healing by enhancing cell viability and reducing oxidant stress.

This paper identifies ABI1 as an epigenetic regulator of transcriptional homeostasis in AR-driven cancers through novel DNA and AR binding mechanisms.

The paper develops and validates a high throughput screening platform using morphological profiling to predict DMD disease phenotype in patient-derived myotubes.

This study identifies RAPSYN-mediated neddylation of BCR-ABL as a mechanism driving Ph+ leukemia progression and presents it as a therapeutic target.

The paper identifies a 78-gene prognostic signature for lung adenocarcinoma that correlates with cell cycle activity and treatment response to PIM inhibitors.

This paper establishes a hairy root culture and genetic transformation system in Stephania tetrandra to enhance bisbenzylisoquinoline alkaloid production.

This study identifies N-myristoylation of Rpt2 as a mechanism for proteasome-membrane interaction, showing its role in membrane protein homeostasis and its impact on cellular processes and tumor growth.

This paper shows that a bispecific antibody targeting PD-L1 and TIGIT enhances T-cell response and tumor control compared to using the individual antibodies.

This study shows that loss of skeletal muscle pyruvate dehydrogenase causes lactic acidosis and early death, but high-fat diets can mitigate these effects.

ProteinGenerator uses a diffusion model based on RoseTTAFold to generate protein sequences and structures simultaneously, validated for functional properties and structural accuracy.

This study identifies a murine gut protozoan that alleviates Clostridium difficile infection by modulating arginine metabolism and host immune responses.

This study shows exogenous Complement C3 reduces apoptosis in human cardiomyocytes by interacting with the intrinsic apoptotic pathway.

The paper identifies broadly neutralizing antibodies against SARS-CoV-2 that target conserved regions on the spike RBD, showing resistance to antigenic drift and suggesting potential vaccine targets.

This study maps ex vivo terminal erythropoiesis from umbilical cord blood mononuclear cells and pluripotent stem cells, identifying differences in regulatory dynamics and CD99 expression affecting erythroid expansion and maturation.

This study shows that varying light intensity affects social interactions and collective behavior in schooling fish by altering their responses to obstacles and group motion patterns.

The study examines meiotic behavior in tea plant pollen mother cells, identifying normal and abnormal phenomena including cytomixis and other meiotic errors.

This study develops DCAF1-based PROTACs to overcome CRBN resistance in targeted protein degradation, demonstrating effective degradation of BTK in CRBN-resistant cells.

This study shows that inhibiting subchondral osteoclastogenesis maintains hypoxia in subchondral bone, slowing osteoarthritis progression by stabilizing HIF-1 and reducing cartilage degeneration.

The paper introduces a method to design pseudosymmetric protein hetero-oligomers by redesigning symmetric homo-oligomers and recombining them to form new hetero-oligomers with high structural specificity.

The paper shows IFN-gamma induces NOS2 and COX2 in ER-breast tumors, linked to poor outcomes, through spatial analysis of tumor microenvironments.

This study shows metformin improves bone healing in diabetic mice by enhancing BMSC differentiation and chondrogenesis.

This study identifies associations between gut microbiota composition and serum metabolites with clear cell renal cell carcinoma, suggesting potential risk factors for tumorigenesis.

The paper develops a method to quantify first and second phase insulin secretion dynamics using an insulin-nanoluc luciferase reporter system, validated through genetic and small-molecule screening.

This paper develops automated tumor immunophenotyping pipelines to predict clinical benefit from anti-PD-L1 therapy in NSCLC and TNBC patients.

The paper uses phylogenomic and phylotranscriptomic analyses to study the evolution of nitrogen-fixing root nodule symbiosis across the Nitrogen-Fixing Nodulation Clade, finding no convergence at the amino acid level and highlighting the role of NIN as a master regulator.

This study shows that B cell-intrinsic STAT3 supports gammaherpesvirus latency and suppresses interferon responses in mice, using a competitive infection model.