X. Liu

This paper shows that Hinokitiol reduces fungal load and inflammation in Aspergillus fumigatus keratitis by altering gene expression and inhibiting fungal growth.

This study identifies a biparatopic VH domain that neutralizes SARS-CoV-2 VOCs, including Omicron, with high potency in vitro and in a mouse model.

This study uses spatial transcriptomics and single-cell RNA-seq to analyze immune microenvironment changes in gastric cancer progression, identifying immune cell dysregulation and key signaling pathways.

The paper uses super-resolution microscopy and a fluorescent probe to analyze lysosome spatial organization relative to mitochondria, revealing changes in distance distribution patterns during autophagy and linking lysosome positioning to mitochondrial health.

This study shows that silencing the nt5 gene in Staphylococcus aureus reduces kidney abscess formation and enhances phagocytosis by host immune cells.

This paper develops a biparatopic nanobody with broad neutralization against multiple SARS-CoV-2 variants, including Omicron, showing strong affinity and activity.

The paper determines the structure of mTORC2 and shows how substrate-specific interactions and conformational changes regulate its activity.

This study shows cell mass homeostasis is maintained throughout the cell cycle, not just at G1/S, using ceQPM to measure dry mass in mammalian cells.

This paper identifies a second DNA binding site in yeast RFC that facilitates clamp loading at nicked or gapped DNA, enhancing DNA repair processes.

This study uses single-nuclei transcriptomics to analyze dog hippocampus cell types and identifies convergence between differentially expressed genes and putative positively selected genes related to nervous system development.

This study identifies HaRxL77, an effector from the plant pathogen Hpa, as hypermobile between cells and manipulates host defence by modifying plasmodesmata permeability and suppressing ROS bursts.

This study determines the cryo-EM structure of active-state RXFP1 bound to relaxin-2 and Gs protein, revealing an autoinhibition mechanism.

The paper identifies piperlongumine as a covalent E3 ligase recruiter that, when conjugated with CDK9 inhibitors, induces targeted protein degradation of CDK9 and EML4-ALK fusion oncoprotein.

This study maps chromatin reprogramming and transcriptional regulation during hexaploid wheat embryogenesis, revealing epigenetic mechanisms governing cell fate and organogenesis.

This paper introduces SPACX, a method to profile protein conformation and interactions in living cells, revealing subcellular-specific heterogeneity and functional differences in PTEN.

This study investigates the role of LHCBM1 in NPQ in Chlamydomonas reinhardtii, showing that its absence reduces NPQ despite normal LHCSR3 expression and pH response.

This study investigates how ALS-associated profilin variants affect actin assembly through biochemical assays and finds that some variants impair actin elongation when formin is present.

The paper identifies PDIA1 as a biomarker of β cell stress in type 1 diabetes using proteomics and validation in mouse models and human samples.

This study develops an organoid-based method to generate large quantities of NK cells from human pluripotent stem cells without feeder cells, achieving efficient and scalable iNK cell production.

This paper develops carbon dot-based fluorescent antibody nanoprobes for glioblastoma diagnostics, showing they are robust, photostable, and applicable in clinical settings.

This study identifies ion homeostasis as a key determinant of bacterial lifespan during starvation, showing that reducing its energetic cost extends survival.

The paper introduces a robust beta regression method for dose-response curve estimation and develops a web tool for its implementation.

This study develops an intranasal vaccine against SARS-CoV-2 using an influenza virus vector and shows it provides rapid, prolonged, and broad protection against multiple variants in hamsters.

This study shows that TAM proliferation in PDAC is driven by CSF1 from fibroblasts, leading to immunosuppression and tumor progression, but also increasing sensitivity to CD40 agonist therapy.

This study identifies ETV2 as a regulator of cell death in Tsc2-deficient cells through PARPBP and ER stress, suggesting a potential therapeutic target for LAM.

This study develops engineered small extracellular vesicles targeting FGL1 and PD-L1 to suppress immune rejection in transplantation by inhibiting T cell activation and improving graft survival.

The paper identifies STAT2 as a regulator of PD-L1 expression through multi-omics analysis and experimental validation, linking it to tumor immune evasion.

This study shows mRNA vaccines induce rapid antibody responses in mice by day 5, outperforming DNA, protein, and adenovirus vaccines for SARS-CoV-2 and HIV-1 antigens.

This paper assesses Virtual Trichrome technologies using Bridge Category Models to account for bridge ratings in Fibrosis staging of NASH tissue.