Y. Wang

This study shows that aging of lung mesenchymal stromal cells impairs the ability of alveolar epithelial stem cells to form 3D organoids, and that reducing Nox4 activity can partially reverse this effect.

This study identifies UBXN3B's critical role in B lymphopoiesis by maintaining BLNK stability and pre-BCR signaling, leading to impaired B cell development and increased vulnerability to viral infections.

The paper analyzes T-cell receptor repertoires in different phases of COVID-19 to identify immune response patterns and predict recurrent infection risk.

This study shows that Ror1/2 receptors are essential for cardiac myofibroblast differentiation and heart remodeling in response to pressure overload.

This study evaluates the antifungal activity of natural borneol against Candida albicans using vapor and liquid phase methods, finding it inhibits hyphae formation at sub-minimal concentrations.

This study analyzes evolutionary changes in Cdx2's DNA binding and transcriptional regulation between mice and rats, finding conserved transcriptional output despite divergent DNA binding.

This study uses cryo-EM to reveal the mechanism of TRiC/CCT ring assembly in yeast, showing subunit-specific roles and ATP-driven assembly dynamics.

This study shows that apoptotic extracellular vesicles (apoEVs) protect liver homeostasis and regeneration by forming a chimeric organelle with the Golgi apparatus and restoring hepatic ploidy.

This study uses single-cell RNA sequencing to identify cell type-specific molecular changes and altered intercellular communications in COPD, linking them to alveolar epithelial dysfunction.

This paper identifies host proteins proximal to 17 SARS-CoV-2 viral proteins, revealing mechanisms of antiviral signaling disruption and host translation inhibition.

This study transfers functional mitochondria into aged CD4+ T cells, improving their metabolism, reducing oxidative stress, and enhancing immune function against infections.

This study identifies OsNLP3 as a key regulator of nitrogen use efficiency and grain yield in rice under nitrate-sufficient conditions.

This paper develops magnetically propelled fecal surrogates to study the impact of solid-induced shear forces on colonic epithelial cells, finding that these forces modulate mucus production and cytokine secretion without harming cell viability.

The paper examines the serological response to the N-terminal domain (NTD) of SARS-CoV-2, showing it is less cross-reactive with SARS-CoV and less effective as an immunogen compared to the RBD.

This paper introduces a JSDM that accounts for imperfect detection and evaluates its performance compared to models that do not, finding that detection must be considered to avoid biased estimates of species correlations and distributions.

This study compares the antitumor effects of live and heat-inactivated oncolytic vaccinia viruses and identifies immune mechanisms underlying their efficacy.

The paper identifies accelerated evolution in the Nrk gene's exons in eutherian mammals, suggesting a new exon ignited positive selection linked to placental development.

Eliglustat inhibits autophagy in osteoclasts, reducing MM bone disease and suggesting its use as a treatment for bone loss disorders.

The paper identifies an immune gene signature linked to MGMT methylation in glioblastoma that predicts prognosis and immune response.

This study evaluates a recombinant chimpanzee adenovirus vaccine expressing a dimeric tandem-repeat RBD of SARS-CoV-2, showing enhanced immune responses and protection in mice.

This study identifies how primary tumor-associated macrophages prime disseminating tumor cells for invasion and dormancy, revealing a critical post-extravasation step in metastasis.

This study identifies five new Asgard archaeal phyla, expands the Asgard superphylum, and supports a 2-domain tree of life by showing Tyrarchaeota as a deeper branching lineage than Heimdallarchaeota.

This study shows that the cationic peptide L-K6 enhances doxorubicin's effectiveness in drug-resistant cancer cells by inhibiting P-glycoprotein function and expression.

This study compares three qRT-PCR assays for SARS-CoV-2 detection, finding that CCDC and IPBCAMS N gene assays outperformed WHO assays, while IPBCAMS ORF 1b assay had higher detection rates than others.

This study uses proteomic analysis of GSK3β knockout colorectal cancer cells to identify altered cell adhesion and metabolic pathways.

The paper identifies two public IGHV3-53/3-66 clonotypes with distinct CDR H3 motifs and shows Y58F mutation enhances binding affinity to SARS-CoV-2 RBD.

This study uses human stem cells to show that HNF1A deficiency leads to impaired insulin secretion, altered insulin:C-peptide ratios, and abnormal secretory granules in beta-cells.

The paper identifies dominant cytotoxic T lymphocyte epitopes of Marek's disease virus, confirms their immunoprotective effects, and highlights key factors for effective antitumor immunity.

This study evaluates mRNA-1273 vaccine efficacy in hamsters, showing reduced pulmonary immune activation and improved disease outcomes after prime-boost vaccination.