Y. Wang

Ligand supplementation restores the cancer therapy efficacy of an antirheumatic drug auranofin from serum inactivation

This study shows that adding thiols to auranofin restores its anticancer activity by modulating albumin-gold binding and enhancing therapeutic efficacy.

Tirzepatide restricts obesity-related tumor growth by reversing metabolic dysregulation and rescuing CD8+ T cell function

This study shows tirzepatide reduces obesity-related tumor growth by improving metabolism and restoring CD8+ T cell function without directly targeting cancer cells.

Biologically Driven In Vivo Occlusion Design Provides a Reliable Experimental Glaucoma Mouse Model

This paper develops a biologically inspired microbead platform for inducing chronic ocular hypertension in mice, leading to retinal ganglion cell loss and visual pathway impairment.

The triose phosphate/phosphate translocator exports photosynthetic glyceraldehyde 3-phosphate from chloroplasts to trigger antimicrobial immunity in plants.

This study identifies AtTPT as a chloroplast transporter that exports glyceraldehyde 3-phosphate to trigger antimicrobial immunity in plants.

Liver cancer initiation is dependent on metabolic zonation but decoupled from premalignant clonal expansion

This study shows that liver cancer initiation depends on metabolic zonation but is not linked to premalignant clonal expansion.

Loss of ZNRF3/RNF43 Unleashes EGFR in Cancer

The paper shows that ZNRF3/RNF43 ubiquitinates and degrades EGFR, and their loss increases EGFR signaling, promoting cancer growth.

Lateral Flow Assays Biotesting by Utilizing Plasmonic Nanoparticles Made of Inexpensive Metals - Replacing Colloidal Gold

This paper develops plasmonic nanoparticles made from inexpensive metals for lateral flow assays, showing they perform as well as or better than gold nanoparticles in biosensing.

Evolution of plant cell-type-specific cis-regulatory elements

The paper constructs a single-cell chromatin accessibility atlas in rice and compares it across grass species to study the evolution of cell-type-specific cis-regulatory elements.

Coordinated molecular and ecological adaptations underlie a highly successful parasitoid

This study identifies molecular and ecological adaptations in the parasitoid Trichopria drosophilae that enhance its success in parasitizing Drosophila hosts.

Signaling events at TMEM doorways provide potential targets for inhibiting breast cancer dissemination

This study identifies CSF-1 signaling as a key mechanism in TMEM doorway function, showing its role in promoting vascular openings and tumor cell intravasation in breast cancer.

RBM7 deficiency promotes breast cancer metastasis by coordinating MFGE8 splicing switch and NF-kB pathway

This study identifies RBM7 deficiency as a driver of breast cancer metastasis through MFGE8 splicing regulation and NF-kB pathway suppression.

Determination and characterization of papillomaviurs and parvovirus causing mass mortality of Chinese tongue sole (Cynoglossus semilaevis) in China

This study identifies two novel viruses, CsPaV and CsPV, as the causative agents of mass mortality in farmed Chinese tongue sole, revealing their co-infection and potential for further research on viral interactions.

"Two-Birds-One-Stone" Oral Nanotherapeutic Designed to Target Intestinal Integrins and Regulate Redox Homeostasis for Ulcerative Colitis Treatment

This paper develops an oral nanotherapeutic, OPNs@LMWH, that targets intestinal integrins and regulates redox homeostasis to treat ulcerative colitis, showing improved therapeutic efficacy and immune uptake.

De novo multi-mechanism antimicrobial peptide design via multimodal deep learning

This paper introduces M3-CAD, a deep learning pipeline for designing multi-mechanism antimicrobial peptides to combat multidrug-resistant organisms, showing effectiveness in a skin wound infection model.

Cooperative dynamics of DNA grafted magnetic nanoparticles optimize magnetic biosensing and coupling to DNA origami

This study shows that DNA grafting density on magnetic nanoparticles affects their dynamics and biosensing performance, with optimal sensitivity at intermediate densities.

A high-fidelity in vitro model of the human intestinal epithelium

This paper develops an in vitro model of the human intestinal epithelium that closely mimics in vivo cell types using single-cell transcriptomics and a biomedical foundation model.

Geometric Quantification of Cell Phenotype Transition Manifolds with Information Geometry

The paper introduces SCIM, a method using information geometry to quantify cell phenotype transition manifolds by analyzing curvature and velocity in single-cell gene expression data.

Orphan nuclear receptor NR2E3 and its small-molecule agonist induce cancer cell apoptosis through regulating p53, IFNα and MYC pathways

This study shows NR2E3 activates p53 and induces apoptosis in cancer cells, with its agonist 11a synergizing with Romidepsin to suppress cervical cancer through multiple molecular mechanisms.

Single-cell transcriptomics reveals cellular hierarchies and aberrant CTS contraction-mediated premature hair regression in androgenetic alopecia

This study uses single-cell transcriptomics to identify cellular hierarchies and CTS contraction as a driver of premature hair regression in AGA, showing ML-7 can improve hair growth.

Phenotypic and transcriptional features of the Araliaceae species under distinct light environments

This study compares phenotypic and transcriptomic features of sun- and shade-grown Araliaceae species under different light conditions, revealing differences in photosynthesis efficiency and gene regulation.

Fluorescent Chiral Quantum Dots to Unveil Origin-Dependent Exosome Uptake and Cargo Release

This study uses chiral quantum dots to investigate origin-dependent exosome uptake and cargo release mechanisms in different recipient cells.

Structural elucidation of how ARF small GTPases induce membrane tubulation for vesicle fission

The paper determines the structure of ARF6 protein lattice on tubulated membranes, revealing its role in vesicle fission and how GAP proteins interact with it.

CD5L associates with IgM via the J chain

This study identifies CD5L as a component of IgM pentamers, showing it binds to the J chain via a disulfide bond and reduces IgM binding to pIgR.

Broadly neutralizing antibody induction by non-stabilized SARS-CoV-2 Spike mRNA vaccination in nonhuman primates

Non-stabilized SARS-CoV-2 Spike mRNA vaccination in macaques induces B cell lineages targeting conserved epitopes on Omicron variants or cross-neutralizing epitopes on Sarbecoviruses.

Mutation of OsCDS5 confers broad-spectrum disease resistance in rice

This study shows that mutating OsCDS5 in rice enhances resistance to multiple diseases by increasing ROS production and defense gene expression.

Site Effects in Multisite Fetal Brain MRI: Morphological Insights into Early Brain Development

This study identifies key MRI acquisition factors affecting fetal brain morphology and shows that ComBat-GAM harmonization effectively reduces site effects while preserving developmental patterns.

Activating SRC/MAPK signaling via 5-HT1A receptor contributes to the effect of vilazodone on improving thrombocytopenia

This study shows vilazodone improves thrombocytopenia by activating SRC/MAPK signaling through 5-HT1A receptor in megakaryocyte differentiation.

Host E3 ubiquitin ligase ITCH mediates Toxoplasma gondii effector GRA35-triggered NLRP1 inflammasome activation and cell-autonomous immunity.

ARHGAP32 as a novel RhoGAP interacting with desmoplakin is required for desmosomal organization and assembly

This study identifies ARHGAP32 as a RhoGAP interacting with desmoplakin, essential for desmosomal organization and epithelial cell sheet integrity by regulating actomyosin contractility.

Battery-Free Optoelectronic Patch for Photodynamic and Light Therapies in Treating Bacteria-Infected Wounds

This paper introduces a battery-free optoelectronic patch for photodynamic and light therapies to treat bacterial infections, showing reduced bacterial load and enhanced tissue regeneration in animal models.