Y. Xiang

This paper develops a method to produce vascularised liver organoids from human PSCs without 2D patterning or ECM, demonstrating liver-like functions and cellular complexity.

The paper identifies STAT3 as an inhibitor of Myocardin-mediated cardiac hypertrophy by directly binding to Myocardin and suppressing its transcriptional activity.

This study shows that cytoplasmic RNAs, particularly tRNAs, regulate cGAS activity by promoting phase separation and modulating its interaction with dsDNA.

This paper identifies potent SARS-CoV-2 neutralizing nanobodies, develops multivalent cocktails with high neutralization potency, and highlights their therapeutic potential.

The paper develops a proteomic strategy to analyze antigen-engaged antibody repertoires, revealing high diversity and specificity of camelid heavy-chain antibodies in binding antigens.

This paper develops a nanobody platform for drug delivery, showing improved pharmacokinetics and therapeutic efficacy of NbHSA conjugates.

This study investigates how nucleotide analogs like Remdesivir affect SARS-CoV-2 polymerase activity using single-molecule techniques, revealing backtracking rather than termination and evasion of ddhCTP.

This study shows that ITGB4 in airway epithelial cells reduces CCL17 production, thereby suppressing Th2 responses and allergic inflammation in asthma.

B cells integrate innate TLR and adaptive CD40 signals to induce BATF3 transcription factor for production of IL-27, which together with INFg optimizes antibody responses.

This paper investigates how perturbing GABA biosynthesis in Arabidopsis affects leaf development by linking it to endoreplication and cell expansion.

The paper withdraws its manuscript due to invalid results and intends to revise the technical approach and interpretation.

This study shows Nrf1 represses tumor growth by inhibiting Wnt/β-catenin signaling and other pathways through ubiquitination of β-catenin and regulation of key genes.

This study shows that Crif1 promotes radiation-induced osteoporosis in mice by increasing RANKL expression and that targeting Crif1 could be a therapeutic strategy.

This study shows β-blockers like carvedilol can activate β2AR at low concentrations, enhancing L-type Ca2+ channel activity in neurons through localized cAMP/PKA signaling.

The paper identifies CP77 as a third orthopoxvirus inhibitor of rodent SAMD9L, showing it uniquely targets Chinese hamster SAMD9L and enables viral replication.

This study identifies α-tubulin in Laodelphax striatellus as a facilitator of rice stripe virus (RSV) passage through midgut and salivary glands, enhancing horizontal transmission.

This study shows that nucleoid size scales with cell size in bacteria, similar to eukaryotes, and links nucleocytoplasmic ratios to translation organization.

This study identifies the molecular mechanisms and post-translational modifications governing the generation of distinct Nrf1α/TCF11 proteoforms and their involvement in feedback circuits with regulatory proteins.

This study identifies topovectorial mechanisms that control Nrf1 proteolytic processing to generate mature CNC-bZIP transcription factor isoforms through ER-associated degradation.

This study assesses the acute and chronic toxicity of benzylpenicillin G residues in heat-treated animal food products using a mouse model, finding reduced LD50 and organ damage at high exposure levels.

This study shows that microtubule acetylation via dTAT is essential for mechanosensation in Drosophila, affecting touch, gravity, and sound responses but not thermal sensing.