Z. Guo

This study uses a tissue-engineered human dermal microvessel model to investigate Borrelia burgdorferi invasion and intravasation, finding no adhesin-mediated interactions and showing Bb-induced endothelium activation.

The paper introduces a raMVR microscope that achieves 6D super-resolution imaging of single molecules with high precision in 3D position and orientation.

This paper introduces MIP-FLF microscopy to enable fast, volumetric infrared spectroscopic imaging of living cells and organisms, revealing lipid metabolism changes in drug-resistant pancreatic cancer cells.

This study shows TDP-43 oligomerization and RNA binding work together to control its stability and localization, and their loss leads to different pathological outcomes.

This study shows dapagliflozin improves hemodynamics and endothelial integrity in endotoxin-treated mice via the ApoM/S1P pathway by preserving megalin expression.

The paper identifies CSC-derived extracellular vesicles that target MHCII- macrophages and PD1+ T cells, suggesting combination therapies targeting these cells may reduce HNSCC recurrence.

The paper sequenced full-length transcriptomes of four reef-building corals to uncover molecular mechanisms of calcification, symbiosis, and circadian genes.

This study shows Harringtonine inhibits SARS-CoV-2 membrane fusion by targeting both the viral S protein and host TMPRSS2, effectively blocking infection in delta and Omicron variants.

This study develops an enzyme-based method to extract plant extracellular vesicles, showing higher yield and therapeutic potential compared to traditional methods.

This study shows PPAR-delta drives metabolic reprogramming in pancreatic cancer, promoting metastasis, and its inhibition reduces invasiveness.

This study identifies METTL3's role in promoting homologous recombination repair and modulating chemotherapeutic response in breast cancer cells by regulating the EGF/RAD51 axis through m6A modification.

This study identifies acoustic and postural displays in Danionella dracula during aggressive interactions, showing differences based on residency and body size.

This study shows that humanized mice can be infected by SARS-CoV-2, leading to immune responses and immunopathology, providing a model for studying the virus and testing therapies.

This study identifies a TM4SF1-positive cancer subpopulation in bladder cancer that drives intratumor heterogeneity and is associated with poor prognosis.

This study shows that SARS-CoV-2 ORF7 increases monocyte chemotaxis via CCL2 and decreases neutrophil recruitment via reduced IL-8.

This study shows that exosomal miR-140-3p from diabetic BMSCs promotes bone restoration in diabetic rats by enhancing osteogenesis and inhibiting the plexin B1 signaling pathway.

This study shows that a 3D microenvironment enhances BBB phenotype and function in iPSC-derived microvessels compared to 2D cultures.

This paper introduces optical cellular micromotion as a method to measure tumour cell invasion in 3D environments, showing it correlates with motility and responds to migrastatic drugs.

This study shows miR-27a-5p suppresses Wilms tumor by inducing apoptosis and inhibiting proliferation, migration, and invasion through targeting PBOV1.

The paper identifies MITEs as a source of new miRNAs in angiosperms, showing they rapidly diversify miRNA repertoires through transposition and transcription.

This study identifies endophilin A1 as a calmodulin effector that drives dendritic spine enlargement via actin polymerization during LTP induction.

This study investigates how Trichostatin A (TSA) affects IL-17A-induced transformation of MRC5 cells into myofibroblasts and identifies the TGF-β1/Smads signaling pathway as the mechanism.

The paper sequenced two mangrove species to show extensive gene flow after speciation, with many small introgression blocks and genomic islets contributing to speciation.

The paper designs chimeric antisense oligonucleotides that degrade SARS-CoV-2 RNA via RNase L activation, showing twice the efficiency of classic antisense oligonucleotides and broad-spectrum antiviral activity.

This study shows prior SARS-CoV-2 infection in golden hamsters provides partial protection but not sterilizing immunity, and virus can still be transmitted between infected and naive animals through direct contact.

This paper investigates the role of apolipoprotein M in anthracycline cardiotoxicity, finding that ApoM protects against cardiac dysfunction and lysosomal injury through the autophagy-lysosome pathway.

The paper analyzes single-cell transcriptomes during liver transplantation to understand ischemia-reperfusion injury and identifies a protective role for TNIP3 in Kupffer cells.

This study characterizes urine metabolomics across the lifespan in healthy individuals, identifying age- and gender-specific metabolic patterns and pathway enrichments.

This study assesses bacterial abundance and diversity in 70-year-old desiccated soils, showing significant resuscitation potential and activity of certain taxa after rewetting.