Z. Li

This study identifies factors that induce CAR-T cells with stem-like properties, enhancing their long-term persistence and antitumor efficacy in vivo.

This paper shows that engineered T cells can cure asthma in mice by targeting eosinophils and blocking inflammatory cytokines.

The paper develops a co-evolution algorithm to predict bacterial iron interaction networks based on siderophore synthetase-receptor gene pairs across Pseudomonas genomes, revealing habitat- and pathogen-specific interactions.

This study identifies Stomidazolone as a chemical inhibitor of the bHLH heterodimer MUTE-SCREAM, disrupting stomatal differentiation in plants.

This study identifies USP10 as a novel regulator of β-catenin through dual mechanisms involving deubiquitination and phase separation, with implications for cancer treatment.

This study shows that a latent Pseudomonas aeruginosa infection in Drosophila melanogaster is silenced by an innate immune response, specifically melanization, and provides protection against secondary infections.

This paper develops a one-step virus detection method using immobilized thermotolerant Ago to separate amplification and cleavage steps, achieving high sensitivity and specificity.

The paper identifies public antibodies using VL6-57 light chains that target a conserved epitope on SARS-CoV-2 spike protein, showing how Omicron variants evolved to escape these antibodies.

This study shows that KRAS inhibition in lung adenocarcinoma leads to an AT1-like cell state that drives resistance, and targeting these cells improves treatment response.

This study develops a toxin-triggered liposomal system that releases antibiotics in response to LtxA from Gram-negative bacteria, showing selective release in LtxA-producing strains.

This paper introduces a method to map amino acid positions and post-translational modifications in single protein molecules with sub-nanometer resolution using FRET-based single-molecule protein fingerprinting.

This paper evaluates the antigenicity and receptor affinity of the SARS-CoV-2 BA.2.86 subvariant, finding it not more resistant to human sera than other variants but with specific mAb resistance and high receptor affinity.

The paper designs and tests a low-cost microfluidic cartridge with a pressure-driven check valve for molecular diagnostics, demonstrating fluid manipulation and integration with a benchtop LAMP system.

This study identifies Thbs4 as a muscle-derived myokine that promotes the conversion of white to beige adipocytes in subcutaneous adipose tissue, improving metabolic health and protecting against high-fat diet-induced disorders.

This study shows ER fusion proteins in breast cancer cell lines drive ligand-independent pro-oncogenic pathways, with subtype- and fusion-specific effects.

This study shows that mitochondrial defects in desmin-mutated cardiomyocytes contribute to cardiomyopathy and can be reversed by transferring normal mitochondria.

This study identifies and characterizes inhibitors of SMARCA4/SMARCA2 ATPases, showing their ability to induce lineage-specific chromatin changes and tumor regression in uveal melanoma.

This paper genetically engineers mesenchymal stem cells to act as a nitric oxide reservoir, enhancing therapeutic efficiency in acute kidney injury by precise spatiotemporal NO release.

This study identifies a mechanism by which tick-borne flaviviruses inhibit interferon signaling by targeting TYK2 catalytic activity through their NS5 protein.

The paper identifies PS clustering by membrane receptors as a trigger for LC3-associated phagocytosis (LAP), revealing a novel PS-mediated signal transduction mechanism.

This study identifies METTL3-mediated stabilization of RRBP1 mRNA via m6A in prostate cancer and develops small-peptide inhibitors to target this pathway.

This paper develops a stapled peptide inhibitor of METTL3-METTL14 that suppresses tumor growth by inhibiting m6A methylation and promoting METTL3 degradation.

This study identifies structurally diverse FSP1 inhibitors that sensitize cancer cells to ferroptosis, with FSEN1 showing potent on-target inhibition and synergy with ferroptosis inducers.

SIDERITE identifies new iron-binding molecules by analyzing chemical structures and confirming their iron-binding ability through experimental validation.

The paper compares genome evolution patterns between aphids and phylloxera, finding distinct X chromosome features despite similar reproductive modes.

This study shows influenza A virus dynamically changes its shape in response to membrane tension, favoring spheres under optimal conditions and filaments under antibody pressure, without requiring genetic changes.

The paper shows that individual behavioral differences in clonal ant colonies influence infection risk by altering division of labour and spatial distribution, leading to increased parasite transmission.

This paper shows artemisitene reduces Schistosoma japonicum infection and liver damage in mice by killing parasites and modulating immune responses.

This paper introduces TCIPs, molecules that activate cell death by rewiring cancer drivers, showing efficacy against DLBCL and potential for broader therapeutic applications.

This study shows that conventional NK cells rapidly lose effector functions upon entering tumors and that IL-15:IL-15Ra complexes can restore their function and tissue-residency.