Z. Wang

This study shows that variations in cuticular hydrocarbons, particularly methyl-branched CHCs, largely explain desiccation resistance differences among Drosophila species.

This study edits two IDA homologues in Brassica napus to prevent petal shedding, enhance silique shattering resistance, and extend flowering period, without affecting agronomic traits.

The paper identifies Muribaculaceae family bacteria as pathobionts that induce insulin-dependent diabetes in mice through translocation to the pancreas following gut microbiota disruption.

This study identifies P-TEFb as a factor that promotes cell survival by suppressing the intrinsic apoptosis pathway when p53 is activated, suggesting its potential as a therapeutic target in combination with apoptosis inducers.

The paper uses a consumer-resource model to show that microbial strains can coexist in boom-and-bust environments by differentiating on Monod parameters, resulting in 1-3 strains coexisting despite theoretical limits.

This study shows that MI-503 inhibits gastrin gene expression by blocking Menin nuclear export in gastrinomas.

This study compares humoral immune responses to different SARS-CoV-2 vaccination regimens, finding differences in antibody and memory B cell responses and neutralizing breadth against variants.

This paper introduces Zeno SWATH, a high-throughput proteomics method that improves protein identification and quantification in small sample amounts using fast chromatography.

This study compares memory B cell responses after single-dose Ad26.COV2.S and mRNA vaccines, finding lower quantities but comparable neutralizing quality in Ad26.COV2.S recipients.

The paper introduces PanGu Drug Model, a deep learning architecture for drug discovery that achieves state-of-the-art results in molecule property prediction, generation, and optimization.

This study shows that SARS-CoV-2 accessory protein ORF8 reduces antibody-dependent cellular cytotoxicity by binding CD16a and decreasing CD16 surface levels on monocytes and NK cells.

This study shows CRISPR/Cas9 can induce exon skipping in β-catenin, creating gain-of-function mutations that drive distinct liver cancer subtypes in mice and are found in human HCC patients.

This study identifies climate-driven factors shaping nematode diversity in forest soils across different climatic zones.

This study shows that seasonality, not photoperiodism, affects the susceptibility of spider mites to pesticides, with toxicity increasing in spring and summer and decreasing in winter.

The paper improves a DNA polymerase's efficiency for unnatural nucleotide incorporation by identifying two key mutations through machine learning and mechanistic analysis.

This study identifies a new RORγt+ antigen-presenting cell type, Thetis cells, that drives microbiota-dependent regulatory T cell differentiation and tolerance during early life.

The paper identifies GATOR1 as a tumor suppressor in MYC-driven lymphomagenesis using in vivo CRISPR screens and shows its sensitivity to mTOR inhibitors.

This study shows that a third mRNA vaccine dose increases the potency and breadth of SARS-CoV-2 neutralizing antibodies, particularly against the Omicron variant, through the expansion and evolution of memory B cells.

The paper identifies miR-306 and miR-79 as tumor-suppressor miRNAs that eliminate JNK-activated tumors in Drosophila by non-canonical activation of JNK signaling through targeting dRNF146.

The paper identifies conserved neutralizing epitopes on the N-terminal domain of SARS-CoV-2 spike proteins using NTD-specific probes and characterizes antibodies that neutralize multiple variants.

This study shows that lymphatic-preserving treatment sequences enhance cDC1-dependent antitumor immunity in HNSCC by avoiding lymphablation, which compromises ICI response.

This study examines blood chemistry changes in goats during a 100-year rain event linked to coccidiosis, suggesting potential clinical applications and climate change implications.

The paper identifies tuftsin as a natural human molecule that targets ACE2 and NRP1, impairing SARS-CoV-2 infection and suggesting its potential as a therapeutic for COVID-19.

This study shows elevated trimethylamine (TMA) in alcohol-associated hepatitis patients and demonstrates that inhibiting gut microbial TMA production protects mice from ethanol-induced liver injury.

This study designs a pan-sarbecovirus vaccine targeting conserved epitopes and shows it induces cross-neutralizing antibodies and T-cell responses in mice and humans.

The paper captures VyPAL2, a plant peptide ligase with a bound substrate, revealing the molecular basis for substrate recognition and ligation.

Skopi generates diffraction images for various XFEL experiments to aid in developing feedback mechanisms for non-crystalline biomolecular structure analysis.

The paper uses computational methods to study fluoride permeation through fluoride channels, finding that electronic polarization plays a key role in F- selectivity and transport.

This study identifies increased chondroitin sulfate proteoglycan levels in fibrolamellar carcinoma through gene expression, mass spectrometry, and single-cell sequencing.

This study demonstrates that microneedle-mediated local delivery of anti-CTLA-4 antibody reduces immune-related adverse events while effectively treating oral squamous cell carcinoma.