Yulong Li

The paper investigates how catecholamine signaling is affected by activity levels, showing that high tonic activity reduces phasic transmission and desensitizes responses.

The paper investigates the timing mismatch between somatic Ca2+ activity and neuropeptide release in Drosophila sLNv neurons, finding that terminal Ca2+ spiking and neuropeptide release peak midmorning, hours before their behavioral effects.

The paper develops improved GRABDA sensors to monitor dopaminergic activity in vivo, showing high sensitivity and spatially resolved DA release in mice during behaviors.

The paper investigates neuromodulator dynamics in mice during a naturalistic reward-threat task, finding distinct roles for norepinephrine, dopamine, and serotonin in encoding motivational states.

The paper develops GRAB sensors for detecting neuropeptides with high specificity and sensitivity, enabling in vivo monitoring of their release and function.

This study shows that timing of dopamine release from VTA to mPFC during specific delay periods modulates working memory performance in mice.

This paper develops improved GRABNE sensors to monitor norepinephrine release in vivo with high sensitivity and uses them to study NE dynamics in mice.

The paper shows astrocytes release ATP spontaneously and non-vesicularly, affecting hundreds of synapses without requiring calcium.

This paper develops dual-color GRAB sensors to monitor spatiotemporal serotonin release in vivo, revealing uniform and gradient release patterns and seizure-induced waves.

The paper develops a predictive model of cocaine relapse using dopamine release patterns and sex, showing that these factors predict relapse and extinction resistance.

This study shows that reducing CB1R signaling in the VTA decreases sign-tracking behavior and alters cue-outcome dopamine dynamics in the NAc of rats.

The paper shows that astrocytic GABA transporters regulate extracellular GABA levels in the SCN, which in turn controls circadian time-keeping through neuronal inhibition.

This study examines dopamine signaling in the dorsal bed nucleus of the stria terminalis during Pavlovian learning and reward violations, revealing strategy-dependent patterns of dopamine responses.

The paper develops a genetically encoded adenosine sensor to show activity-dependent non-vesicular adenosine release from somatodendritic regions via calcium influx and equilibrative transporters.

This paper develops genetically encoded sensors to measure histamine release in vitro and in vivo, showing high sensitivity and specificity for extracellular histamine detection.

The paper shows that serotonin signaling modulates the coincidence time window in Drosophila associative learning by a feedback circuit involving ACh and 5-HT.

The paper develops a new oxytocin sensor to study compartmental OT release in neurons and finds distinct calcium channel roles and fusion machinery differences in axons and somatodendritic regions.

The paper uses dual-color mesoscopic imaging in awake mice to show that cholinergic and cortical activity are spatiotemporally heterogeneous and linked to behavioral states.

This study identifies norepinephrine as a threat prediction error signal during fear learning, contrasting with dopamine's role in reward prediction.

GESIAP is a MATLAB-based image analysis program that processes genetically encoded sensor data to analyze neuromodulator transmission properties across cell types and species.

This paper develops a new genetically encoded fluorescent cAMP indicator, G-Flamp1, which shows high sensitivity, brightness, and fast response kinetics for in vivo cAMP imaging.

The paper shows that dopamine and acetylcholine levels in the striatum of mice fluctuate spontaneously with the same temporal relationship as during reward, driven by glutamatergic afferents rather than direct interactions between the neuromodulators.

The paper shows that dopamine activates PFC astrocytes via α1-adrenergic receptors, leading to calcium signals and regulation of extracellular ATP.

This study uses a genetically encoded dopamine sensor to measure dopamine release in the nucleus accumbens during social behaviors in mice, revealing distinct patterns in different phases of social interaction.

This study investigates how locus coeruleus-norepinephrine system activity and astrocytic responses change during sleep states, revealing dynamic fluctuations in norepinephrine levels and their relationship to sleep processes.

This paper introduces a neuropsin-based optogenetic tool, cOpn5, that enables precise control of Gq signaling with high temporal and spatial resolution.

The paper investigates how microglia change their phenotype in acute brain slices and how these changes affect neuronal network activity.

The paper introduces an in situ cut-and-paste genome editing method using CRISPR/Cas9 or Cas12a, demonstrating its ability to insert, substitute, and delete sequences in mammalian genomes.

The paper shows that associative learning induces compartmentalized, bidirectional plasticity of acetylcholine release in Drosophila mushroom body axons, with valence-dependent effects and distinct molecular mechanisms.

This study investigates how adenosine A1 receptors inhibit dopamine release in the nucleus accumbens, showing that astrocytic ENT1 regulates this inhibition and that ethanol disrupts it.