biophysical modeling

The paper characterizes bacterial diversity and adaptive traits in the Atacama Desert using 16S rRNA sequencing and whole genome sequencing of isolates.

This paper investigates the redox reactivity of membrane-bound Aβ1-42-Cu2+ complexes and shows that metallothionein-3 can suppress their harmful effects by reducing Cu2+ to Cu+.

The paper identifies genes associated with stromal resistance to placental and cancer invasion by comparing species and analyzing fibroblast responses.

The paper shows (p)ppGpp inhibits c-di-GMP synthesis in Caulobacter crescentus, linking metabolic stress to developmental arrest through direct molecular interaction.

This paper identifies digitiferin, an antimicrobial peptide from coral Acropora digitifera, which exhibits bactericidal activity against Vibrio coralliilyticus under low-salt conditions.

The paper investigates how periodic changes in cell polarity during migration are controlled by pulsations in Rac1 activity in live zebrafish embryos.

The paper analyzes >12,000 bacterial genomes to study the conservation and evolution of the programmed ribosomal frameshift in prfB, finding it was present in the last common ancestor of bacteria and linked to stop codon usage.

This study uses molecular dynamics simulations to show that increasing cholesterol concentrations reduces amyloid-induced membrane poration.

This study characterizes AcrIF11, an ADP-ribosyltransferase that inhibits CRISPR-Cas systems with high potency and specificity, and shows its reversibility through macrodomain enzymes.

The paper identifies T-dioxygenases in bacteriophages, revealing a subclass requiring a regulator protein for oxidation and structural insights into their function.

This study uses genomic data and a particle-tracking model to investigate the dispersal and stranding dynamics of Physalia physalis along the US East Coast.

This study shows that KLHL3 and WNK kinases are regulated by O-GlcNAcylation, affecting osmolarity control and ferroptosis, with implications for blood pressure and neuronal health.

This study links PIWIL2 downregulation in colon cancer to increased transposon activity and pro-tumorigenic phenotypes through bioinformatic and cell-based analyses.

This paper develops a biophysical model to explain how HIV-1 capsids translocate through the nuclear pore complex, showing that competitive binding and geometric changes enable fast and complete nuclear import.

The paper determines the structure of a plant-virus xrRNA and shows it forms a pseudoknot that confers exoribonuclease resistance, revealing a conserved mechanism across diverse viruses.

This study investigates the structure and function of human Xkr4, showing it scrambles lipids and adopts a novel conformation that promotes membrane thinning, essential for phosphatidylserine externalization.

The paper examines ant head shape evolution, finding that narrow heads with deep vertex depressions distribute stress more evenly, while broader heads concentrate stress around mandibular articulations, leading to biomechanical limitations.

The paper identifies two strategies using multichannel pharmacology to prolong action potential duration while reducing transmural dispersion of repolarization in cardiac myocytes.

The paper shows that core and shell proteins in paraspeckles compete for RNA binding, leading to layered condensate organization through immiscibility and competitive binding.

The paper identifies TcIMPDH as a druggable target for Chagas disease and shows AVN-944 has potent inhibition and selectivity in infected cells.

This study shows that intrinsically disordered regions (IDRs) of ER-phagy receptors drive ER fragmentation, not their membrane-remodeling domains.

This study shows that a monovalent MGD can recruit two E3 ligases redundantly to degrade SMARCA2/4, with tunable ligase preference through chemical and genetic modifications.

This study shows that GTP hydrolysis by AMPH-1 drives membrane remodeling through oligomerization and tubulation, essential for transport carrier formation.

This study identifies the molecular mechanism of gephyrin clustering at GABAergic synapses, showing collybistin and phosphoinositides drive high-molecular weight complex formation, while gephyrin phosphorylation at Ser325 disrupts it.

The paper shows Nde1 enhances Lis1 binding to autoinhibited dynein, facilitating Phi conformation opening through a novel intermediate state.

The paper converts an agonistic anti-TNFR2 biparatopic antibody into an antagonist by inserting peptide linkers into the hinge region, altering its immunocomplex formation.

The paper identifies ehOTUB1, a microsporidian deubiquitinase that inhibits human UBE2K's ubiquitin conjugation activity by blocking its interaction with the E1 enzyme.

This study uses biophysical modeling to assess how ocean circulation, temperature, and food supply affect larval recruitment of purple sea urchins in Southern California, finding that adult temperature exposure and larval behavior significantly influence recruitment.

This paper identifies FimX as a regulator of T4P positioning in Acinetobacter baylyi through interaction with the Pil-Chp chemosensory system.

This study investigates how pathogenic BRCA1 mutations disrupt BARD1-mediated allosteric control, revealing conformational changes that impair E3 ligase activity and contribute to cancer.