cell signaling & trafficking

This study examines circulating CD4 regulatory T cells in Parkinson's disease and finds they are largely preserved in phenotype and function, though show reduced HELIOS expression in naive subsets.

The paper investigates experience-dependent plasticity in somatostatin interneurons and identifies two-pore potassium (K2P) channels as a mechanism underlying this plasticity.

This paper develops a framework to engineer oncolytic vaccinia virus to support off-the-shelf NK cells by aligning viral payloads with NK cell manufacturing limitations.

This study shows STMN2 regulates microtubule dynamics and axonal resilience in human motor neurons, linking cytoskeletal homeostasis to ALS pathology.

DIALECT enables synthetic cells to communicate with mammalian cells via DNA-programmed ligand release and engineered receptors, achieving specific signaling and logic gate functions.

This paper demonstrates a drug-free method using laser-induced vapor nanobubbles to create immunogenic whole-cell vaccines for bladder cancer, showing reduced tumor growth and immune activation.

This study shows that tissue-like viscoelastic substrates enhance muscle stem cell expansion by creating mechanical memory through focal adhesion stabilization and Rac-Akt signaling.

This study shows that mechanical stress influences age-related changes in vestibular hair cell differentiation and regeneration through Notch signaling.

This study shows hypoxia induces LARP1-driven stress granules that protect mRNAs from decay, sustaining mitotic progression in cancer cells.

The paper predicts a cohesin acetylation complex in budding yeast that interacts with nicked DNA and confirms its function through experiments.

This study shows that IL4Ra signaling in SP thymocytes prolongs their medullary dwell time, enhancing their maturation and functional capabilities.

This study identifies the circadian clock's role in coordinating the Notch-to-Wnt signaling switch to enhance regenerative myogenesis in muscle stem cells.

This study shows that TMEM11-dependent cristae architecture limits mtROS production, thereby restraining IMQ-induced NLRP3 inflammasome activation.

The paper investigates how two types of layer 5 neurons in mouse secondary visual cortex process delta-theta rhythmic input, finding differences in filtering but not in spike timing once firing.

This study shows that haemoglobin from haemolysed plasma interferes with bioluminescence assays in ciPTECs, but does not severely injure the cells.

The paper uses imaging and modeling to study transient leaks in epithelial tight junctions, finding that dynamic strand breaking and sealing explain leak behavior at the junction level.

This study shows that yeast Gcn2 promotes P-body formation through eIF2α phosphorylation and Smu2-dependent mRNA granule maturation, even when eIF2α phosphorylation is blocked.

This study shows HIF1A-AS2 regulates the switch from HIF-1 to HIF-2 signaling in hypoxia by reducing HIF1A expression and increasing HIF-2 activity in endothelial cells.

BEHAV3D-Explorer provides a user-friendly platform for analyzing 3D live-cell imaging data using natural language guidance to select analysis strategies and configure workflows.

The paper shows that heat stress reverses the growth-promoting thermomorphogenesis pathway in Arabidopsis by suppressing auxin and PIF4 in cotyledons, revealing an active molecular mechanism.

This study shows that MCV small T protein recruits HSP70 to facilitate LT helicase remodeling and DNA unwinding, revealing a conserved mechanism for replication complex assembly.

This study reveals how mitochondrial complex III assembles from preformed matrix domain modules, showing dynamic subunit exchange and the role of specific residues in assembly and disease.

The paper identifies a non-canonical smooth muscle-like hypercontractility program in LUSC myCAFs using nanomechanical phenotyping, linking it to tumor mechanics and adverse outcomes.

The paper investigates how EGF and EREG influence early oncogenic transformation in intestinal organoids by altering crypt and villus development.

This study identifies reactive cysteine residues in NLRP3 and shows how their oxidation by ROS affects NLRP3 conformation and inflammasome activation.

The paper identifies three classes of palindromic regions in RNA based on structural context and availability, and evaluates their self-interaction stability using simulations.

This paper develops a conductive hydrogel that reduces glial and vascular damage in traumatic brain injury models.

This study identifies extensive horizontal gene transfer in the fungus gnat Bradysia coprophila, showing these genes contribute to stress tolerance and ecological adaptation.

The paper shows neurons entrain an intrinsic arteriole rhythm, shaping blood distribution and vascular responses through frequency-dependent mechanisms.