Neurotransmitter Receptor Influence on Behavior

This study investigates sex differences in mTORC1 activation and rapamycin's effect on alcohol use in male and female rodents.

This study shows that manipulating ERK2 levels in the nucleus accumbens of rats alters behaviors related to reward and aversion, with overexpression increasing depression-like and cocaine sensitivity behaviors, and knockdown reducing them.

This study examines RyR2 expression and localization in the vmPFC during drug and sucrose self-administration and reward recall, finding that drug recall alters RyR2P distribution and increases its somatic expression.

This study investigates how OEA affects alcohol self-administration and gene expression in specific brain regions, finding region-specific changes in dopamine and cannabinoid receptor genes and immune responses.

The paper examines transcriptomic changes in D1 and D2 medium spiny neurons of the nucleus accumbens after cocaine and morphine exposure, revealing shared and divergent regulatory patterns.

This paper proposes a theory that serotonin neurons encode predictive value signals, explaining various serotonergic responses better than existing theories.

This study investigates the role of mGlu2 deletion in Emx1-lineage neurons on behavioral flexibility in mice, finding no significant impact on drug consumption predisposition.

The paper identifies genetic influences on ethanol consumption in Diversity Outbred mice by analyzing gene expression and eQTLs in the prefrontal cortex.

This study shows that reducing GABA release from central amygdala neurotensin neurons decreases alcohol drinking in male mice but not females, with distinct behavioral effects in each sex.

This study examines how acute and prolonged morphine withdrawal affects motivation and goal-directed behavior in rats, finding distinct impacts on reward processing and flexibility.

This study shows that the D3R antagonist VK4-116 improves behavioral flexibility in rats with a history of cocaine use during abstinence.

This study shows that D1+ neurons in the nucleus accumbens fire more during reward expectation and trial initiation, while D2+ neurons respond more to reward delivery.

This study shows that timing of dopamine release from VTA to mPFC during specific delay periods modulates working memory performance in mice.

The paper characterizes heterogeneity in dopaminergic neurons across midbrain and olfactory bulb in mice, finding substantial differences in morphology and function between brain regions.

The paper identifies two disruptive SERT variants in treatment-resistant affective disorder patients and shows they cause partial loss-of-function, with one variant responsive to pharmacochaperoning.

This study shows that deleting D2 receptors from striatal cholinergic interneurons impairs action sequence learning, while viral replacement rescues this behavior.

This study replicates a positive association between serotonin 2A receptor binding and inward facets of neuroticism using the [11C]Cimbi-36 tracer and finds no moderating effect of cortisol awakening response.

The paper identifies molecular differences in the hippocampus between AUD-prone and AUD-resistant mice during alcohol withdrawal.

This study shows that VTA dopamine projections to the lateral amygdala are critical for cocaine cue associative learning but not for cocaine's direct rewarding effects or reinstatement via priming injections.

This study shows dopamine signals prediction errors during both latent learning of value-neutral cues and reward-based conditioning, suggesting a domain-general role in model-based learning.

This study examines how cue extinction affects dorsal striatal activity during goal-directed and habitual cocaine seeking, finding reduced DMS responses but not DLS responses.

The paper investigates how genetic variations affecting endosomal sorting processes influence neural responses in the reward system using fMRI and gene set analysis.

This study examines how outcome devaluation via sensory-specific satiety affects Pavlovian-conditioned behavior in male and female rats, finding sex differences in response sensitivity.

This study shows sex differences in cocaine-induced plasticity in D1- and D2-MSNs of the mouse nucleus accumbens shell, with males showing reduced D1-MSN excitability and females showing increased D2-MSN excitability.

This study shows chronic alcohol exposure increases social avoidance in male mice by enhancing serotonergic inputs to the nucleus accumbens, which inhibits dopamine release and reduces social motivation.

This study investigates the role of ventral pallidum to ventral tegmental area neurons in reward-seeking behavior, finding they reinforce but do not invigorate reward-seeking.

This study shows that unpredictable, intermittent reward access increases reward-seeking behavior in rats, suggesting implications for addiction modeling.

The paper shows that VTA dopamine neurons respond to both food and social stimuli, with overlapping populations and increased overlap under hunger or social experience.

This study shows that amphetamine induces sex-dependent endocytic down-regulation of the dopamine transporter in sensitized mice, with effects observed in the nucleus accumbens but not the dorsal striatum.

This study examines how junk-food diets affect food-motivated behavior and NAc glutamate plasticity in obesity-prone and resistant rats, identifying mechanisms of CP-AMPAR recruitment.