Malaria Research and Control

This study identifies conserved CD4+ T cell epitopes in PfCSP and shows their HLA-independent presentation, suggesting potential for strain-transcending malaria vaccines.

This study identifies the mitochondrial pyruvate carrier in Plasmodium berghei as non-essential for blood stages and ookinete formation, revealing an alternative metabolic pathway for acetyl-CoA production.

This study uses genomic data to show that imported Plasmodium falciparum infections from Gabon are contributing to malaria transmission on Bioko Island, highlighting the need for regional control efforts.

This study shows that host PMCA4b variations affect intraerythrocytic calcium and ROS levels, reducing artemisinin sensitivity in malaria parasites.

This study uses time-lapse microscopy to compare the effects of Chloroquine and Cabamiquine on Plasmodium falciparum-infected red blood cells, revealing Cabamiquine's delayed cytotoxic effect.

This study shows that S-type ribosomes in Plasmodium yoelii are not essential for mosquito-stage development but promote host-to-vector transmission and have distinct roles in blood-stage development.

This study uses metagenomics to analyze trophic interactions of Anopheles gambiae larvae in freshwater ecosystems, revealing shared resources and non-exclusive predation patterns.

This study uses computational methods to analyze the mutational landscape of Plasmodium falciparum DHFR, revealing evolutionary pathways and co-evolving networks that contribute to antifolate resistance.

This study investigates the role of anemia and tissue hypoxia in hyperlactatemia during severe malaria using a murine model and human samples.

This study identifies DMT1 and a chromosome 12 locus, including FtsH1, as novel contributors to Plasmodium falciparum resistance to quinine, alongside the known pfcrt gene.

This study uses scRNA-seq to identify gene expression profiles of asexual and sexual merozoites in Plasmodium falciparum, revealing key genes involved in invasion and sexual commitment.

The paper quantifies hemoglobin consumption variability in Plasmodium falciparum-infected red blood cells and attributes it to non-genetic host cell differences.

This paper develops a nanopore sequencing method to distinguish recrudescence from new infections in antimalarial trials, achieving high sensitivity and specificity.

The paper uses barcoded P. falciparum gene knockouts with BarSeq to phenotype parasite life cycle traits at scale.

The paper uses Micro-C to map DNA-DNA contacts in Plasmodium falciparum, revealing heterochromatic and euchromatic structures mediated by MORC/ApiAP2 and other factors.

This paper develops a chemogenomic platform using Plasmodium berghei artificial chromosomes to identify antimalarial drug targets through barcode sequencing and validation in Plasmodium falciparum.

This paper aggregates spatiotemporal data on 112,933 Plasmodium falciparum samples to track the global spread of artemisinin resistance, highlighting its emergence in East Africa and the role of genomic surveillance.

This paper identifies MMV1580853 as a fast-acting antimalarial with a mechanism distinct from artemisinin and chloroquine, showing rapid parasite killing in vitro.

This study designs antibodies targeting the LILRB1 receptor's D1D2 domain to block RIFIN-mediated immune evasion in malaria parasites, enhancing NK cell activity.

This study shows that somatic hypermutation increases cross-reactivity of anti-PfCSP antibodies by enhancing flexibility in antigen-bound complexes, but reduces serum stability.

Pf-HaploAtlas provides an interactive web tool for analyzing spatiotemporal genomic variation in Plasmodium falciparum using data from 16,203 samples across 33 countries.

This study shows that influenza co-infection protects mice from malaria-induced acute lung injury by altering immune responses, specifically through arginase-1-expressing alveolar macrophages.

MalKinID identifies malaria parasite genealogical relationships using IBD proportions and segment distributions, showing high accuracy in outcrossed importations but reduced performance in inbreeding scenarios.

This study investigates the association of PfACAS mutations S868G and V949I with antimalarial drug resistance using whole-genome sequencing and CRISPR/Cas9-engineered parasites.

This study models the effectiveness of combining insecticide-treated nets and indoor residual spraying for managing insecticide resistance in malaria control.

This paper evaluates deliberate and accidental micro-mosaics of insecticide deployments for resistance management, finding they are not beneficial compared to rotations or mixtures.

This paper identifies mCMQ069, a novel antimalarial with potential for single-dose cure and one-month chemoprevention, showing improved pharmacokinetic properties over KAF156.

This study identifies IgM as a key antibody isotype in immune responses against Plasmodium falciparum gametocytes, showing its superior complement fixation activity compared to IgG.

This study shows declining genetic diversity and purifying selection in Plasmodium knowlesi in Thailand, linked to increased transmission, with genetic similarity between southern Thailand and Malaysia.