Pain Mechanisms and Treatments

The paper uses single nuclei RNA sequencing and spatial transcriptomics to analyze human trigeminal nerves and neuromas, identifying molecular changes associated with neuropathic pain.

The paper identifies SLC45A4 as a pain-related gene encoding a neuronal polyamine transporter through GWAS and functional studies.

This study investigates the role of CeAGA neurons in acute and late-phase neuropathic pain, finding they have distinct effects on pain thresholds and anxiety behaviors.

This study demonstrates the use of engineered zinc finger repressors delivered via AAV to reduce SCN9A expression in preclinical models, showing efficacy in reducing neuropathic pain.

This study shows that satellite glial cells modulate proprioceptor activity via Gq GPCR signaling and purinergic receptors, suggesting therapeutic targets for sensorimotor disorders.

The paper identifies Nageotte nodules in diabetic painful neuropathy DRGs, showing they contain dead neurons and are linked to pain and sensory loss.

The paper identifies persistent changes in nociceptor mRNA translation following hyperalgesic priming and shows Gpr88 and Metrn regulate this state.

This study investigates how genomic and transcriptomic profiles interact with brain morphology to influence individual differences in pain sensitivity using multi-omics data from 432 participants.

The paper investigates how endocrine signaling and neuroimmune communication regulate neonatal pain, finding that GH signaling via STAT1 influences inflammatory pain through a novel neuroimmune loop.

This study identifies NGF-TrkA-PI3K signaling in keratinocyte-nociceptor interactions as a driver of obesity-induced small fiber neuropathy and suggests targeting these interactions as a therapeutic strategy.

This study identifies a brainstem circuit involving LPBN and RVM neurons that mediates pain-induced suppression of itch in mice.

The paper isolates nerve terminals from NaV1.9 knockout mice and performs proteomic analysis to identify dysregulated pathways in neuropathic pain signaling.

This study shows that ZFHX3 deficiency in mice leads to altered pain responses and reduced cautious-like behavior in both sexes, with female mice showing specific hypoalgesia to mechanical stimuli and hyperalgesia to heat.

This study shows that CBD3063, a CRMP2 modulator, reduces OA pain in rodents by decreasing CaV2.2 membrane expression and neural activity.

This paper evaluates synergistic antinociceptive effects of cannabinoid, adrenergic, and opioidergic agonists in a pain model using isobolgraphic analysis and combination indexes.

This study identifies keratinocytes and PDGF-B/PDGFRβ signaling as key mediators of peripheral opioid tolerance in mice, showing that PDGF-B release from keratinocytes drives tolerance through activation of PDGFRβ in sensory neurons.

The paper shows that spinal projection neurons reduce excitability during acute pain but not chronic pain, preventing pain chronification through increased potassium currents.

This study identifies CST-targeted spinal interneurons as a key circuit in chronic neuropathic pain following CNS injury in mice.

This study shows that conditioned medium from painful schwannomatosis tumors induces pain behaviors in mice, with effects varying based on tumor mutations.

This study shows that 12/15-Lipoxygenases contribute to neuropathic-like pain hypersensitivity in female mice, with inhibitors reversing pain symptoms.

The paper shows IL-6 increases nascent protein synthesis in human DRG nociceptors through MNK1/2-eIF4E signaling, using human DRG explants and inhibitors.

This study shows that uncertainty in thermosensory expectations enhances the perception of pain in the thermal grill illusion through predictive coding mechanisms.

This study identifies VLK as an extracellular kinase that mediates EphB2 phosphorylation and pain responses by regulating synaptic protein interactions.

The paper examines changes in nociceptive Schwann cells and terminal nerve fibers in a mouse model of prediabetic neuropathy, identifying L1CAM as a new marker for these cells.

The paper identifies parabrachial neurons expressing the NPY Y1 receptor as a hub that suppresses sustained pain through NPY signaling.

The paper compares genetic and pharmacological loss-of-function mechanisms of Nav1.7 analgesia, highlighting distinct opioid-dependent and -independent pathways in embryonic and adult stages.

This study identifies a BLAnoci ensemble in the basolateral amygdala that mediates both acute and chronic pain behavior through a novel amygdala-striatal circuit involving the nucleus accumbens shell.

The paper identifies NR1C2's role in inflammatory pain by showing its regulation via Magi-2 and Nedd4-1 ubiquitin ligase, and demonstrates pharmacological targeting of NR1C2.

This study shows that macrophages protect against sensory axon degeneration in diabetic neuropathy by delaying axonal loss through CCR2 signaling.