Mitochondrial Function and Pathology

This paper visualizes beat-to-beat ATP dynamics in ventricular myocytes of male and female mice, revealing sex-specific mitochondrial and cytosolic ATP production strategies.

This study identifies nutrient-responsive mitochondrial-derived structures in C. elegans muscle cells induced during refeeding, revealing a role in mitochondrial remodeling and metabolic adaptation.

This study identifies IP6K1 as a regulator of mitochondrial polyP synthesis and function, showing its role in energy homeostasis through 5-InsP7 production and a catalytic-independent mechanism.

The paper identifies toxic intermediate complexes formed during mitochondrial complex I assembly in NDUFS4 mutant mice, revealing hypoxia's role in rescuing disease by preventing pathological reverse electron transfer.

This study identifies ATAD3 as an essential component of the mitochondrial permeability transition pore (mPTP), showing its role in mPTP opening and reducing cardiac ischemia reperfusion injury.

This paper develops a Seahorse-based protocol to assess metabolic fuel usage in cardiac organotypic slices from human and mouse, showing its sensitivity and applicability across species.

The paper shows complex I regulates mitochondrial iron levels in bats, linking respiration to lipid metabolism and enabling metabolic flexibility for flight.

This study identifies PAF1 as a plant-specific assembly factor for the membrane arm of complex I, showing that assembly pathways differ between plants and mammals.

The paper studies mitochondrial morphogenesis during spermiogenesis in Drosophila, showing how coordinated membrane dynamics and vesicle-mediated remodeling drive organelle patterning.

This study shows that metformin improves mitochondrial function and neurogenesis in POLG mutant brain organoids by activating the AMPK/SIRT3/mTOR pathway.

This study shows that dendrite injury causes mitochondrial contraction and increased dendrite branching, regulated by KCNJ2 and Drp1.

This study shows that aging reduces axonal translation in sensory neurons, linked to decreased mitochondrial activity and ATP levels, which can be partially reversed by increasing ATP synthesis.

The paper investigates the role of the Mitochondrial Calcium Uniporter (MCU) in protecting hippocampal CA2 neurons from excitotoxic injury, finding that MCU expression correlates with resistance to NMDA-induced damage.

This study shows synaptic mitochondria prefer fatty acids over glucose for energy production, enhancing respiratory flexibility and ATP content in neurons.

The paper investigates the mechanism of age-related mtDNA mutation accumulation in human blood using whole genome sequences, revealing a two-step process involving cryptic mutations and clonal expansion.

This study shows that Drosophila Mtx2 is critical for beta-barrel protein biogenesis and muscle growth during pupal stages, but not larval stages, revealing stage-specific roles in mitochondrial function and muscle development.

The paper identifies the proximity interactome of the MICOS complex using APEX2 fusion proteins, revealing a network of proteins involved in mitochondrial biogenesis and function.

This study shows that expressing alternative oxidase (AOX) reduces reverse electron transfer and oxidative stress in ischemia-reperfusion brain injury, preserving complex I function and providing neuroprotection.

This study investigates how DJ-1 deficiency and aging jointly impact mitochondrial function in the retina and RPE, showing reduced OXPHOS complex levels and increased mtDNA damage.

The paper models mitochondrial fission and fusion dynamics using the Belousov-Zhabotinsky reaction framework, showing oscillatory behavior and therapeutic implications in disease states.

This study shows that impaired mitochondrial fusion in yeast leads to mtDNA loss due to unequal distribution and reduced synthesis.

The paper investigates how glucose deprivation affects mitochondrial RNA stability and transcription, revealing a metabolic link to mitochondrial gene regulation.

The paper assesses the impact of 13 mitochondrial factors on axonal microtubule organization in Drosophila neurons to identify mechanisms linking mitochondrial dysfunction to neurodegeneration.

This study examines how chemical mutagens affect mitochondrial DNA ploidy in iPSC cells, finding that certain mutagens cause significant changes in mitochondrial DNA content and organization.

This paper develops a high-content system to quantify mitochondrial morphology in patient-derived human cells, finding Huntington Disease fibroblasts have smaller, more circular mitochondria indicating increased fission.

The paper develops a method to profile mitochondrial function in specific kidney segments from mice and humans under thermodynamic control, revealing segment-specific bioenergetic differences.

The paper develops a fluorescent sensor to image ER-mitochondria contacts in live cells and shows nutrient deprivation reduces these contacts via PDZD8.

The paper uses cortical organoids to show MLC1 mutations cause mitochondrial hyperactivation and increased neural progenitor proliferation.

This study shows abnormal tau protein increases mitochondrial transfer from astrocytes to neurons via contact-dependent mechanisms, affecting mitochondrial function in tauopathies.

This study quantifies 4D mitochondrial networks in human organoids during development, identifying distinct phenotypes linked to cell type and age.