Circadian rhythm and melatonin

The paper develops a computational model to explain mitochondrial Prx/Srx redox oscillations in mammalian tissues, showing that delayed feedback and switches generate robust 24-hour rhythms.

This study examines lactate metabolism in the medial prefrontal cortex of aged and circadian desynchronized mice, finding disruptions in circadian rhythms and gene expression related to neurometabolism.

This study shows that Shank3 modulates sleep and circadian transcription factor expression in mice, with sleep deprivation exacerbating gene expression differences between Shank3 mutants and wild types.

The paper identifies a circadian pathway in Drosophila where morning and evening oscillators drive pre-motor centers via specific dopaminergic neurons, resulting in a two-peak locomotor activity pattern.

The paper develops bioluminescence reporter lines in Nannochloropsis species to study circadian rhythms and identifies a circadian oscillator in stramenopiles.

The paper shows BMAL1 DNA binding is tissue-specific and regulates rhythmic transcription through enhancer-enhancer interactions in the mouse liver.

The paper identifies a novel AstC/AstC-R2 signaling pathway in Drosophila that modulates evening locomotor activity under short photoperiods.

This study shows HNF4A trans-represses CLOCK:BMAL1 and is a core component of tissue-specific circadian networks in liver and colon cells.

This study measures pupil responses to melanopsin-directed contrast pulses and finds they are reliable and insensitive to background radiance changes.

LimoRhyde provides a flexible framework for analyzing rhythmic transcriptome data, enabling detection of differential rhythmicity and expression in circadian systems.

This study identifies MDM2 as a regulator of PER2 degradation and shows it influences circadian rhythm period length through a phosphorylation-independent mechanism.

This study shows how the circadian clock and environmental cycles influence cell size control and division timing in cyanobacteria.

The paper identifies robust circadian rhythms in human skin at the population level and develops single-sample biomarkers for circadian phase.

The paper performs a bifurcation analysis of a mammalian circadian clock model to understand how gene expression and protein activity influence oscillatory dynamics and feedback loops.

This study shows that LPS induces Stat3 mRNA expression in the SCN with daytime peaks and that night-time LPS injection delays locomotor activity recovery in rats.

This paper identifies a circadian output circuit in Drosophila that regulates sleep-wake arousal threshold by connecting circadian neurons to homeostatic sleep centers.

This study shows that foraging time in honey bees affects the molecular clock, with phase differences in clock genes and stronger effects when food is scented with linalool.

This study shows that dKDM2 is not essential for Drosophila viability but regulates circadian rhythms, with loss-of-function mutants showing arrhythmic behavior and overexpression causing shorter periods.

The paper analyzes mouse genome data to show ultradian genes are more evolutionarily conserved and linked to dawn/dusk transitions.

This study identifies genetic loci associated with circadian rhythmicity using UK Biobank data and finds polygenic associations with mood instability and major depressive disorder.

The paper improves rhythm detection in sparsely sampled genome-wide expression time series using bootstrapping and empirical Bayes methods, showing better consistency than existing methods.

The paper shows Drosophila S2 cells exhibit daily gene and metabolic oscillations without canonical circadian regulators.

This study identifies how VIP SCN neurons use firing rates and neuropeptide release to entrain circadian rhythms in gene expression and behavior.

The paper identifies tissue-specific circadian feedback loops by fitting mathematical models to gene expression data from different mammalian tissues.

This study shows that melanopsin-mediated pupil responses are impaired in early-stage Parkinson's disease, suggesting a potential biomarker for disease detection and monitoring.

The paper examines single-cell circadian rhythms in Arabidopsis seedlings, revealing robust oscillations and spatial waves of gene expression that coordinate clock activity across the plant.

The paper investigates how circadian gene expression is regulated across tissues by analyzing transcription factor activity rhythms and chromatin interactions in mouse tissues.

This study shows BMAL1 regulates astrocyte activation and function through cell-autonomous and non-cell-autonomous mechanisms, impacting neuronal survival and brain health.

The paper identifies novel circadian transcripts in the zebrafish retina and distinguishes between light-entrained and free-running oscillations.

The paper shows natural light changes affect circadian gene expression in cyanobacteria through RNA polymerase recruitment controlled by transcription factors.