Memory and Neural Mechanisms

Htr3a receptors control attenuation of fear responses by modulating the corticolimbic network activity and synchronization

This study shows that Htr3a receptors are essential for normal fear response attenuation by regulating oscillatory dynamics and synchronization in the corticolimbic network.

Formation of Task Representations and Replay in Mouse Medial Prefrontal Cortex

This study shows that task representations in the mPFC form de novo during learning, with neural sequences involved in evaluating outcomes rather than planning actions.

Ultraslow entorhinal oscillations shape spatial memory through grid cell drifting

The paper shows ultraslow entorhinal oscillations affect spatial memory by causing grid cell drifting and enabling dynamic access to different spatial memories.

Learning, sleep replay and consolidation of contextual fear memories: A neural network model

This paper introduces a neural network model of contextual fear memory consolidation, incorporating sleep-related processes like replay and synaptic homeostasis to explain memory stabilization and fear generalization.

Distinct representational properties of cues and contexts shape fear learning and reversal

This study investigates how the brain represents cues and contexts during fear learning and reversal, finding distinct neural strategies that predict fear renewal.

Noradrenaline causes a spread of association in the hippocampal cognitive map

This paper shows that noradrenaline causes a spread of association in the hippocampal cognitive map, leading to overgeneralisation errors and predicted by physiological markers.

Persistently increased expression of PKMζ and unbiased gene expression profiles identify hippocampal molecular traces of a long-term active place avoidance memory and 'shadow' proteins

The paper identifies molecular traces of long-term memory using gene expression and protein analysis, revealing shadow proteins like PKMζ that are not detected by transcriptome profiling.

Response dynamics of discrete subiculum->retrosplenial cortex projections underlying trace fear conditioning

The paper investigates how specific subiculum-to-retrosplenial cortex projections contribute to trace fear conditioning by analyzing their activity patterns during memory formation and recall.

Network reorganization distinguishes vulnerability and resilience to observational fear

The paper identifies distinct brain network architectures associated with susceptibility and resilience to socially acquired fear in rats.

GABAergic inhibition differentially gates recruitment of dentate gyrus interneurons by lateral entorhinal cortex inputs.

This study investigates how GABAergic inhibition controls the recruitment of dentate gyrus interneurons by lateral entorhinal cortex inputs in adult mice.

The relationship between cortisol, grid-like representations and path integration

This study shows cortisol impairs path integration by disrupting grid-like representations in the entorhinal cortex, affecting navigational performance.

Deconstruction of a memory engram reveals distinct ensembles recruited at learning

This study identifies distinct neuronal ensembles in dorsal CA1 that are differentially active during associative fear memory acquisition and reveals which ensembles form the core engram.

Hippocampal representations of temporal structure increase in scale and symmetry across development

The paper shows that hippocampal representations of temporal sequences reorganize during development, with increased temporal scale and bidirectional integration.

Locus Coeruleus-Amygdala Circuit Disrupts Prefrontal Control to Impair Fear Extinction

This study shows that stress and LC activation promote NE release in the BLA, disrupting vmPFC activity and impairing fear extinction.

Toroidal topology of grid-cell activity precedes spatial navigation during development

This study shows that toroidal manifolds in the MEC emerge early in rat pups, preceding spatial experience and exploration, suggesting innate computational motifs in spatial navigation.

Efficient memory sampling by hippocampal attractor dynamics with intrinsic oscillation

This paper introduces a momentum Hopfield model to explain how hippocampal attractor dynamics enable prioritized memory sampling, enhancing reinforcement learning for spatial navigation.

Active pursuit gates egocentric coding in Retrosplenial Cortex

The paper identifies head-centered target-encoding neurons in retrosplenial cortex during active pursuit, showing task-dependent retuning and coexistence of egocentric and allocentric coding.

MDMA enhances prefrontal plasticity and representational drift during fear extinction

This study shows MDMA increases prefrontal spine density and enhances functional connectivity during fear extinction, leading to accelerated representational drift in specific neurons.

Neural geometric representations of social memory for multi-individuals in medial prefrontal cortex

The paper shows that low-dimensional geometric subspaces in mPFC neural activity encode social memory of multiple individuals based on their social valence.

Acquisition and extinction of drug-context memories are linked to distinct epigenetic and transcriptional mechanisms in the mouse dentate gyrus

This study shows that drug-context memory acquisition and extinction in mice involve distinct epigenetic and transcriptional changes in the dentate gyrus, with non-overlapping genomic regions and gene functions.

Distinct hippocampal mechanisms support concept formation and updating

The paper uses fMRI and computational models to identify neural mechanisms for memory creation and updating during learning, finding distinct hippocampal involvement in learning outcomes.

vCA1 SST neurons represent avoidance states that guide anxiety-related behavioral choices

The paper identifies vCA1 SST interneurons as key regulators of avoidance behavior by showing their selective recruitment during avoidance and their role in shaping behavioral responses in threatening environments.

Modulation of exploration-avoidance behaviors by vmPFC-projecting BLA neurons

This study inhibits vmPFC-projecting BLA neurons in mice and finds it promotes avoidance behaviors in an elevated zero maze task, contrasting previous findings on BLA projections to mPFC.

Safety Signals Enable Single-Episode Active Avoidance paradigm and Expose Threat Generalization in Tuberous Sclerosis Complex

This study introduces a novel behavioral paradigm to assess threat discrimination and shows that oxytocin-modulated translational control stabilizes threat-safety discrimination, with disruptions leading to generalized avoidance in Tuberous Sclerosis Complex.

The Combinatorial Capacity and Robustness of Hierarchical Concept Coding in the Human Medial Temporal Lobe

This paper introduces a hierarchical coding framework to explain how the human medial temporal lobe encodes semantic concepts with high capacity and robustness, and applies it to understand Alzheimer's disease progression.

Time cells differentially populate trace and post-trace epochs, but do not remap for different trace intervals

The paper investigates time-cell behavior in trace-eyeblink conditioning, finding distinct time-cell epochs and no remapping between different trace intervals.

Differential modulation of aversive signaling by expectation across the cingulate cortex

The paper uses calcium imaging in mice to show that the retrosplenial cortex flexibly reorganizes during shock prediction, while the anterior cingulate cortex encodes ongoing nociception and defensive behavior.

Brain bases for navigating acoustic features

The paper investigates the neural basis of navigating an auditory dimension in humans, finding overlapping brain systems with physical navigation.

Dynamic updating of cognitive maps via traces of experience in the subiculum

The paper proposes a computational model of subiculum processing that explains vector trace cells (VTCs) and their role in updating spatial memory through mismatch detection between perceptual and mnemonic inputs.

Transcriptional Changes Fade Prior to Long-Term Memory for Sensitization of the Aplysia Siphon-Withdrawal Reflex

The paper investigates how transcriptional changes decay over time relative to long-term memory in Aplysia, finding that transcriptional changes fade faster than behavioral memory.