Microtubule and mitosis dynamics

This study shows that the hydrophobic patch mediates cyclin-CDK localization to the centrosome, which is essential for mitotic entry and CDK substrate phosphorylation.

The paper screens for genes affecting Drosophila female meiosis by testing RNAi constructs in germline-specific promoters to identify defects in chromosome congression and Mps1-GFP sequestration.

This study shows that the BUB-1 TPR domain directly binds phosphorylated KNL-1 motifs, essential for BUB-1-BUB-3 localization and function in C. elegans.

This study develops a method to express and purify recombinant cyclin B-Cdk1 and demonstrates its ability to perform multi-site phosphorylation in vitro, including on the condensin I complex.

This study reveals that myosin-5 takes variable step lengths along F-actin tracks, adapting to angular disorder in the track structure.

This study investigates the collective dynamics of formin and microtubule networks, revealing FHDC1's role in regulating actin wave nucleation and its crosstalk with microtubules.

This study shows Nek2A unclusters extra centrosomes and induces cell death in cancer cells, but not in normal cells, through interaction with KIF2C.

The paper shows that the CUL4-DDB1-DCAF1 E3 ligase complex targets PLK4 for degradation in G2 phase to prevent premature centriole duplication.

This study identifies distinct roles of Aurora A in regulating PAR protein localization during different stages of the C. elegans cell cycle, explaining varied polarity phenotypes observed in RNAi experiments.

This study shows that Kid (KIF22) forms a homodimer, moves processively along microtubules, and transports double-stranded DNA, reclassifying it as a processive and dimeric motor.

This study shows FBXB-65 regulates UNC-104 anterograde transport by modifying it near the PH domain, affecting cargo transport efficiency and motor dynamics.

The paper determines the high-resolution cryo-EM structure of the human KMN network, revealing its subunit organization and phosphorylation-dependent regulation.

The paper investigates the relationship between microtubule length and spindle size in C. elegans meiosis, finding a positive correlation and demonstrating the role of microtubule length in determining spindle dimensions.

This study identifies OSGN-1 as a conserved flavin-containing monooxygenase that stabilizes the intercellular bridge during late cytokinesis in C. elegans and human cells.

This study shows that F-actin, via Cofilin-1 and Arp2/3, promotes microtubule severing during cytokinetic abscission, independent of membrane scission.

This study edits endogenous tubulin to assess how different posttranslational modifications affect axonal growth and regeneration in C. elegans neurons.

This study shows that human kinesin-5 KIF11 drives helical motion and orbiting of microtubules, enabling flexible filament organization and torque regulation during mitosis.

The paper identifies kinesin-1 and RIC-7 as polarized transport complexes at the leading end of mitochondria driving anterograde axonal transport in C. elegans.

The paper identifies how Spo13Meikin rewires the phosphoproteome through kinase activity to drive two meiotic divisions in budding yeast.

This study shows that SAS-6 is essential for centriole formation in mouse embryos but not in mouse embryonic stem cells, highlighting context-dependent requirements.

The paper identifies two molecules that activate nitrotyrosine ligation to detyrosinated α-tubulin by targeting TTLL12, which suppresses this process, suggesting potential therapeutic applications for cancer and related pathologies.

This paper shows that prolonged PLK4 overexpression leads to centrosome amplification through interconnected centrosome rosette clusters (CRCs) that depend on centrosomal linker proteins.

This study identifies CKAP2 as a microtubule growth factor that regulates microtubule dynamics and ensures accurate chromosome segregation, with its loss leading to segregation errors and aneuploidy.

This study identifies the KIF18A alpha-4 helix as a therapeutic target, showing that mutations or inhibitors targeting this region disrupt proliferation of chromosomally unstable tumor cells.

This study functionally analyzes Cdc20's role in mitotic checkpoint signaling by identifying the CRY box's critical role in SAC through MCC formation and APC/C interaction.

The paper visualizes dynein and dynactin movement in axons, finding they move long-range together but are delivered separately to the axon tip.

The paper shows that Ca2+ oscillations drive cytoplasmic backflow, which helps maintain spindle position during fertilized mouse egg division.

The paper compares phosphoproteome changes during mitotic exit and meiosis I completion in budding yeast, finding qualitative rather than quantitative phosphoregulation at meiosis I end.

This study investigates HMMR's non-mitotic role in regulating TPX2 localization and microtubule dynamics in neurons, revealing its impact on neuronal morphology.

This study identifies a specialized Ran-GTP-driven spindle structure in medaka embryos that ensures accurate chromosome segregation during early cleavage divisions.