Ion channel regulation and function

This study shows HCN channels modulate action potential velocity and fidelity in central axons through cAMP and neuromodulators, with implications for energy consumption and temporal delays.

This study identifies the Drosophila ERG channel (sei) as critical for neuronal homeostasis and stress resistance, with implications for human hERG mutations in seizures.

This study identifies a gain-of-function mutation in the UNC-2/CaV2α channel in C. elegans that causes hyperactivity and excitation-dominant synaptic transmission by altering cholinergic and GABAergic transmission.

The paper investigates how Ca2+-activated K+ channels affect network excitability and sensory perception in Drosophila mutants, showing their role in improving adaptability and reducing energy costs.

The paper identifies and characterizes new ion channel subunits in skate electroreceptors through RNA-seq, cloning, and cross-species comparisons, revealing potential roles in generating fast oscillations.

The paper identifies tissue and cell-type specific expression of a splice variant of Cacna1b in mouse nervous system regions.

This study examines how type II diabetes affects neuronal excitability and ion channel expression in female mice's major pelvic ganglion neurons over time.

The paper quantifies differences in sodium channel density across segments of the electrosensory lateral line lobe and links these differences to burst coding and network regulation.

The paper investigates how membrane lipids modulate KIR channels in cerebral arteries to sense hemodynamic stimuli and regulate brain perfusion.

The paper analyzes SNPs in VGICs to identify disease-associated mutations and their functional impact on ion channel structure and function.

This study uses molecular dynamics simulations to uncover the dynamic interactions and conformational changes in the N-terminal domain of IP3 receptor during IP3 binding, revealing key molecular events in receptor activation.

The paper presents cryo-EM structures of LRRC8A in lipid nanodiscs with DCPIB inhibitor, revealing gating mechanisms and lipid-dependent structural changes.

The paper shows ionic current correlations exist in mouse neurons, extending findings from invertebrates to vertebrates.

The paper identifies a novel CaV2.2 channel antagonist with broad antinociceptive effects and reduced side effects in pain models.

This study uses droplet-hydrogel bilayers to simultaneously record electrical activity and visualize fluorescently labeled Piezo1 channels, demonstrating their insertion and activation.

This study investigates how ADAM22 and ADAM23 influence the targeting of LGI1 to the axon initial segment in rat hippocampal neurons.

The paper identifies how the HCN voltage sensor can drive pore opening in either direction, revealing a common principle in voltage-gated ion channels.

The paper uses computational models to show how neuromodulators in Drosophila photoreceptors trade off contrast gain against membrane bandwidth by modulating voltage-dependent K+ conductances.

The paper shows that h-channels contribute to differences in electrophysiological properties between human and mouse supragranular pyramidal neurons.

The paper investigates the role of M-current in a collision detecting neuron, showing it regulates firing mode and spike reliability to enhance collision detection.

This study identifies KCNJ13 as critical for tracheal tubulogenesis by maintaining ion homeostasis and actin polymerization in smooth muscle cells.

TraceSpecks automates noise removal and state quantification in patch-clamp and imaging data, providing accurate and detailed analysis of ion channel behavior.

The paper investigates voltage-gated sodium channels in rat neocortical pyramidal neurons and finds they exhibit Cole-Moore activation kinetics rather than traditional Hodgkin-Huxley kinetics.

This study shows that Ca2+/CaM inhibition of Drosophila EAG channels regulates presynaptic excitability and memory formation.

The paper identifies 267 NaV1.7-associated proteins in mice using epitope-tagged gene targeting and mass spectrometry, including novel interactors validated by co-immunoprecipitation and functional assays.

This study identifies ERG channel modulation as a mechanism governing persistent firing in rodent neocortical pyramidal cells through reduced leak K+ current and increased input resistance.

This study identifies a pathway by which dopamine modulates NCA channel activity in C. elegans through Gq-Rho and GRK-2 signaling.

This paper introduces an unsupervised algorithm based on the Minimum Description Length principle to idealize ion channel recordings, demonstrating its effectiveness in recovering channel currents and substates from noisy data.

This study identifies NCA-1 and NCA-2 as downstream targets of the Gq/Rho pathway in C. elegans, showing their role in regulating locomotion through neuronal activity.