Autophagy in Disease and Therapy

The paper identifies SQSTM1/p62 as a key autophagic receptor for CYP4A degradation, showing its role in preventing proinflammatory metabolite production and insoluble aggregates in liver cells.

The paper reports the crystal structure of a GABARAP~ATG3 conjugate, revealing a non-covalent interaction between GABARAP and the backside of ATG3's E2 catalytic center, which is important for PE conjugation.

The paper shows that neurons with Parkinson's disease-associated LRRK2 mutations increase secretion of autophagosomes and exosomes to manage cellular waste and communication, potentially delaying disease onset but contributing to neuroinflammation.

The paper shows that ATG8a turnover via the Arg/N-degron pathway regulates autophagy and thermotolerance in Arabidopsis during heat stress.

This study examines how obesity, caloric restriction, and exercise affect autophagy signaling in skeletal muscle, finding that CR+Ex reduces body mass and alters autophagy markers differently in red and white muscle.

The paper identifies stress-specific autophagy regulators using CRISPR screens, finding unique kinases for ER-phagy and pexophagy.

This study shows that lysosomal membrane permeabilization enhances the effectiveness of RNA Polymerase I inhibitors against cancer cells.

This study identifies a conserved PRP4K-CHMP4B/vps32 splicing circuit that regulates autophagy in both human cells and Dictyostelium discoideum.

This study identifies the p97-UBXD8 complex as a regulator of peroxisome abundance by suppressing pexophagy through ubiquitylation of PMP70.

The paper measures autophagic flux in 19 human blood cell sub-populations using flow cytometry, finding differences by cell type, sex, and age, with non-classical monocytes responding uniquely to amino acid withdrawal.

This study examines autophagic flux changes with age and diet in mice, revealing sexual dimorphisms across tissues.

The paper identifies two mitophagy peaks during retinal development, one PINK1-independent and one PINK1-dependent, linked to oxidative stress and RGC differentiation.

The paper shows ATG9A and ARFIP2 work together to regulate PI4P levels for lysosomal repair during damage and bacterial infection.

The paper identifies novel compounds that reduce lipid droplet accumulation in podocytes by inducing lipophagy, offering potential therapeutic benefits for lipid metabolism disorders.

This study identifies LAMP2B as a mediator of microlipophagy, showing its role in preventing obesity and related metabolic disorders through enhanced lipid hydrolysis.

This study shows that differential expression of GABARAP family members in GBM affects temozolomide sensitivity through p53 regulation.

This study shows that activating the alpha7 nicotinic receptor in macrophages triggers TFEB nuclear translocation and a pro-inflammatory gene signature without cytokine release.

This study shows that rapamycin-induced autophagy enhances lipid breakdown and reduces lipotoxicity in Atlantic salmon cells.

This study shows EMCV uses its 2C protein to degrade NDP52, evading autophagy and promoting viral survival.

The paper presents a fragment-based approach to improve LIR prediction using AlphaFold2, showing that fragment length and phosphomimetic mutations affect interaction predictions.

This study identifies RET-1d as an ER-phagy receptor mediating heat stress adaptation in C. elegans by promoting autophagosome biogenesis in neurons and epidermis.

This study shows age-related autophagy decline in RPE contributes to AMD, and topical trehalose improves autophagy and protects against light-induced retinal damage in mice.

This study examines sex-specific differences in autophagy and mitophagy in Alzheimer's disease using mouse models and machine learning to predict cellular outcomes.

The paper investigates RNase T2's role in ribosome autophagy in yeast, showing Rny1p's function in rRNA degradation and its importance for starvation adaptation.

This study identifies AKAP11 as a scaffold linking autophagy to PKA signaling, showing its role in phosphorylation regulation and neuronal homeostasis, with implications for schizophrenia and bipolar disorder.

The paper identifies an unconventional autophagic pathway that sequesters ATP to prevent its release during apoptosis, reducing immunogenicity.

This study shows that macroautophagy-induced lysosomal damage limits quiescent cell re-entry, and reducing this damage can enhance cell cycle re-entry in C. elegans and mammalian cells.

This study develops an image-based profiling approach to characterize autophagy-related phenotypes with high temporal resolution and identifies key morphological features for drug response prediction.