Neurogenesis and neuroplasticity mechanisms

The paper shows that mitochondria dynamics in postmitotic cells influence neurogenesis via Sirtuin-1-mediated chromatin remodeling in mouse and human cortical neurogenesis.

This study reprograms astrocytes to neurons after stroke, resulting in functional recovery and mature neuronal subtypes.

The paper shows BMP4 reduces H3K4me3 levels in human neural stem cells by downregulating SETD1A and WDR82, leading to decreased proliferation and increased differentiation.

This study shows environmental enrichment stimulates structural remodeling of pre-existing myelinated axons and oligodendrocytes in young adult mice, increasing axon diameter and myelin thickness without enhancing new myelin production.

This study investigates brain regeneration in adult Drosophila after traumatic injury, showing functional recovery and the generation of new neurons and glia.

This study shows that canonical Wnt/{beta}-catenin signaling modulates the timing and progression of dendritic growth in adult-born hippocampal neurons, with distinct effects in young and aged mice.

This study identifies CRL5 as a regulator of hippocampal development by controlling Arl4c and Arf6, which are essential for pyramidal neuron migration and dendritogenesis.

This study identifies CXCL5 as a negative regulator of myelination and repair after white matter stroke, mediated through endothelial signaling in a diet-induced obesity model.

This study shows that inhibiting Lipocalin-2 and Early Growth Response Protein 1 promotes oligodendrocyte differentiation and remyelination after white matter injury.

This study identifies retinoic acid signaling as critical for prefrontal cortex development and connectivity in primates, showing its role in molecular patterning, synaptogenesis, and evolutionary expansion.

The paper shows that signaling environments can control the diversity of neural progenitor cell populations in culture using single-cell RNA-seq and computational analysis.

This paper generates glial progenitor cells from human bone marrow stromal cells and shows their ability to remyelinate a congenitally dysmyelinated mouse model, improving motor function and lifespan.

The paper compares oligodendrocyte generation dynamics in mice and humans, finding that mouse precursors do not vary division times and that murine oligodendrogenesis resembles human patterns.

The paper identifies ABHD4 as a mediator of developmental anoikis that protects the prenatal brain from pathological insults by eliminating abnormally detached progenitor cells.

The paper shows that single oligodendrocyte loss in mouse cortex triggers precise remyelination and cell replacement, preserving original myelin patterns while creating new internodes on unmyelinated axons.

The paper disrupts enhancers and genes in human neural stem cells to study their effects on proliferation and identifies regulatory elements linked to neurodevelopmental disorders.

This study accelerates the maturation of human stem cell-derived cortical interneurons by activating mTOR signaling through PTEN deletion or AKT activation, enhancing synaptogenesis and dendritogenesis.

The paper describes a mouse model where a subset of CNS neurons is labeled by a Cre reporter system originally intended for immune cells.

This study examines age-related differences in oligodendrocyte precursor cells (OPCs) from mice and humans, showing distinct metabolic patterns and responses to FGF2 and anosmin-1 across developmental stages.

This study identifies a mutation in RRP7A linked to primary microcephaly, showing its role in neurogenesis, ribosomal biogenesis, and ciliary resorption in neural stem cells.

The paper identifies distinct neural progenitor pools in the LGE that generate diverse striatal spiny projection neurons with different properties and circuit integration.

This study shows that perinatal fluoxetine exposure in mice increases hippocampal neurogenesis at postnatal day 12 and persists at postnatal day 60, with no effect on neuron survival but increased cell death.

The paper shows that refeeding after fasting rapidly activates oligodendrocyte differentiation in the hypothalamic median eminence, altering extracellular matrix proteins and using mTORC1 signaling to monitor nutritional signals.

This study shows that γ-secretase inhibition in OPCs reduces OL differentiation and increases astrocyte specification through Hes1-Stat3 regulation.

This study shows that the paternal allele of the p57Kip2 gene is expressed in the developing mouse neocortex and its deletion reduces brain size by decreasing neural stem-progenitor cells.

The paper shows that MIR3607 promotes cerebral cortex expansion by activating Wnt/βCatenin signaling in mouse embryos and human organoids.

The paper identifies distinct oligodendrocyte populations with spatial preferences and differential responses to spinal cord injury.

The paper examines damage-related changes in the cerebellum of juvenile Oncorhynchus masou, showing increased proliferation and astrocytic response following injury.

The paper tracks progenitor cell movements in zebrafish embryos to uncover coordination mechanisms between neural crest and placode-derived lineages during olfactory neurogenesis.