Retinal Development and Disorders

The paper investigates how ON and OFF bipolar cells contribute to visual acuity through edge detection mechanisms in the retina.

This study shows that REEP6 deficiency causes retinal degeneration by reducing phototransduction proteins due to ER and Golgi dysfunction and inflammation.

This study identifies metabolic impairments and oxidative stress in Prpf31 mutant mouse RPE cells as key factors in retinitis pigmentosa pathogenesis.

The paper investigates how partial cone loss differentially affects two OFF ganglion cell pathways in the mouse retina, revealing distinct circuit modifications and functional changes.

This study evaluates AAV gene therapy in BCM mouse models, finding that older mutant mice show reduced treatment efficacy due to decreased transduction and cone degeneration, while specific promoters remain active.

The paper identifies Ankyrins as critical for synaptic connectivity between horizontal cells and photoreceptors in the mouse retina through single-cell RNA sequencing and functional analysis.

The paper develops a biophysical model of rod photoreceptors in mice to analyze the electroretinogram (ERG) a-wave, confirming that extracellular capacitive current and HCN1 channel activity shape the a-wave's relaxation and plateau.

This study shows that S1P signaling in Müller glia restricts immune cell accumulation, impairs neuron survival, and suppresses neurogenic reprogramming in damaged mouse retinas.

This study identifies master regulator genes involved in rod photoreceptor regeneration from endogenous progenitors in zebrafish retinas using single-cell RNA sequencing and gene knockdown experiments.

This study identifies YY1's role in zebrafish retina regeneration by showing its regulation of transcription, signaling pathways, and gene expression during Muller glia reprogramming.

The paper develops and validates high-throughput assays to assess RPE65 variant expression levels, aiding in reclassifying variants of unknown significance as pathogenic.

The paper develops a 4-shell current source density model to explain the biophysical basis of the in vivo electroretinogram in mice, showing it better explains ERG waveforms than the classic Rodieck-Ford model.

This study generates and compares T206A and K42E Dhdds mutant mice to model RP59, finding similar retinal degeneration phenotypes despite different mutation combinations.

This study identifies interleukin-34 signaling and mononuclear phagocyte debris clearance as critical for RPE regeneration in zebrafish.

The paper shows that phagocytosis of cone outer segments in larval zebrafish varies by cone subtype, with UV and blue cones showing rhythmic peaks while green and red cones are phagocytosed more evenly.

This study examines transcriptomic changes in grafted human neural progenitor cells and host retinal cells in a retinitis pigmentosa model, identifying mechanisms for vision preservation.

The paper examines how flicker-induced light stimulation affects retinal blood flow and electroretinography in mice, finding increased blood flow and b-wave amplitudes compared to steady light.

This study investigates the mechanism of photoreceptor cell death in rats exposed to prolonged LED light, finding that necroptosis, not apoptosis, is the dominant pathway in retinal degeneration.

The paper maps the spatial distribution of retinal ganglion cell types and identifies perivascular RGCs that show neuroprotection after optic nerve injury.

The paper identifies Sox15 as a transcription factor that promotes cone photoreceptor differentiation by inhibiting alternative rod fates in the developing mouse retina.

This study shows that PEDF deficiency in mice increases light-induced retinal damage, with worsened visual function, retinal thinning, and Galectin-3 expression.

This paper introduces a technique combining two-photon microscopy and multi-electrode array recordings to study the functional interaction between photoreceptors and retinal ganglion cells in acute retinal explants.

This study shows that the w1118 genetic background significantly affects ERG responses in Drosophila, with sex-specific differences and partial compensation by a UAS-hPLD1 construct.

The paper uses bulk and single-cell RNA sequencing to study Norrin's role in retinal neurogenesis, finding altered gene expression and cell composition in NDP knockout retinal organoids.

This study investigates how mislocalized P23H rhodopsin affects synaptic protein levels in rod photoreceptors using mouse models and proteomics.

The paper shows that passage 1 human iPSC-derived RPE cells form more extensive monolayers after transplantation compared to passage 2 cells, highlighting a subpopulation with higher transplantation potential.

This study shows that viral-mediated Oct4 overexpression and Notch inhibition together induce neurogenic competence in mammalian Muller glia, enabling transdifferentiation into bipolar neurons.

This study shows that AAV-mediated delivery of proneural factors to adult Müller glia stimulates neurogenesis in vivo, producing neurons similar to those in the retina.

The paper investigates whether visual cortex and superior colliculus in rd10 mice show cross-modal plasticity after retinal degeneration, finding no significant changes in tactile or auditory responses but detecting abnormal oscillatory activity.

This paper introduces a novel mouse model of dominant retinitis pigmentosa caused by the RHO{Delta}I255 mutation, showing rapid photoreceptor degeneration, neuroinflammation, and disrupted neuronal connectivity.