Retinal Development and Disorders

The paper shows that On-cone bipolar cells use NaV channels from coupled amacrine cells to enhance signal transmission in dim light.

This study characterizes a LacZ knock-in/knock-out allele at the Vsx2 locus in mice, revealing its role in retinal development and identifying potential incomplete knock-out effects.

A mutation in AdipoR1 causes retinal degeneration in a subset of Cfh-/- mice, suggesting a genetic interaction between Cfh and AdipoR1.

This study enhances plasmid-based transcriptional activation in developing mouse photoreceptors by using optimized cis-regulatory elements from the Crx gene.

This study shows that blocking P2Y receptors with suramin prevents stress-induced RPE and photoreceptor degeneration in vitro and in a zebrafish model.

The paper investigates the loss of shortwave cone opsins in cartilaginous fish, linking it to eye adaptation and the presence of tapetum lucidum.

This study shows that Oa1 deficiency in mice impairs retinal neurogenesis by reducing CREB phosphorylation, leading to disrupted differentiation and binocular vision.

This study identifies aberrant splicing caused by the NR2E3 c.932G>A mutation and shows that splice-shifting ASOs can restore full-length protein function.

The paper tests a drug to reduce noise in retinal circuits of mice with retinitis pigmentosa, finding it preserves visual sensitivity while decreasing circuit noise.

This study investigates the therapeutic potential of RPE-secreted small extracellular vesicles in rescuing photoreceptors in retinal degeneration, showing gene expression reversal and functional improvement in a rat model.

IBEX imaging enables simultaneous identification of all cell types in the vertebrate retina across multiple species.

This paper models retinal rewiring in retinitis pigmentosa using pathoconnectomics and predicts altered signaling patterns in Aii amacrine cells.

This study identifies a specific Muller glia subpopulation that can be reprogrammed into photoreceptor-like cells through transplantation of human amniotic epithelial cells.

Hexafluoro improves visual function and reduces retinal degeneration in zebrafish models of Usher syndrome 1F by protecting photoreceptors from light-induced damage.

This study identifies and characterizes wide-field amacrine cells in mouse retina that encode stimulus orientation through molecular and functional analysis.

This study identifies a small molecule cocktail that reprograms Muller glia into retinal neurons, restoring vision in mice with RGC injury.

The paper identifies 18 genes regulating retinal ganglion cell regeneration in zebrafish using a combination of genetic models and single-cell omics.

This paper demonstrates a dual-AAV gene therapy strategy for USH1F, restoring hearing, balance, and retinal function in mouse and human models.

This study identifies a novel ABCA4 mutation and demonstrates significant genetic and phenotypic diversity in ABCA4 retinopathies among Lebanese families.

This study identifies FAT3's role in bipolar cells for high-frequency light response in mouse retina, showing its necessity for synaptic localization of GRIK1.

This study shows that inhibiting Notch signaling and NFI factors can efficiently reprogram adult mammalian retinal glia into neurons, with enhanced effects under retinal injury.

This study investigates the effects of HBS1L deficiency on retinal dystrophy, showing proteomic changes and photoreceptor cell loss in both human and mouse models.

The paper identifies evolutionarily conserved VSX2 enhancer modules in retinal development and shows their functional conservation across species.

This study shows that Taprenepag, a PGE2 receptor agonist, improves cilia formation and light sensitivity in CEP290-deficient models by stimulating cAMP synthesis.

This study shows that metabolic states, particularly glycolysis and oxidative metabolism, influence RPE cell fate decisions during regeneration.

This study shows that increasing rod outer segment growth in zebrafish does not lead to accelerated shedding, revealing principles of size control.

This study investigates the spatial distribution and functional integration of displaced ipRGCs in mice, showing they form complete mosaics with their regularly placed counterparts.

This study shows that Abca4 inhibition in a cone-rich rodent model leads to retinal degeneration similar to human Stargardt Disease type 1.