Sleep and Wakefulness Research

Social defeat induces REM sleep fragmentation through the PFC-VLPO pathway

This study shows that the PFC-VLPO pathway regulates REM sleep fragmentation in response to social defeat stress.

Hypothalamic supramammillary neurons that project to the medial septum control wakefulness

The paper identifies hypothalamic supramammillary neurons projecting to the medial septum as a key circuit for controlling wakefulness through optogenetic and chemogenetic experiments.

Ultrastructural effects of sleep and wake on the parallel fiber synapses of the cerebellum

The paper investigates how sleep and wake affect parallel fiber synapses in Purkinje cells, finding that sleep increases 'naked' spines and alters branched synapse dynamics.

Early life sleep disruption has long lasting, sex specific effects on later development of sleep in prairie voles

This study investigates how early life sleep disruption affects later sleep patterns in prairie voles, finding sex-specific changes in REM and NREM sleep in adulthood.

Targeting targeted memory reactivation: characteristics of cued reactivation in sleep

This study investigates the characteristics of cued memory reactivation during sleep and identifies optimal cue timing for enhancing memory through targeted reactivation.

Mapping Typical and Altered Neurodevelopment with Sleep Macro- and Micro-Architecture

The paper develops a sleep-based metric to quantify brain maturation using EEG data from children, showing high accuracy in predicting chronological age and detecting neurodevelopmental differences.

Wearing an Eye Mask During Overnight Sleep Improves Episodic Learning and Alertness

Wearing an eye mask during sleep improves episodic memory and alertness the next day, with benefits linked to increased slow wave sleep.

Relating pupil diameter and blinking to cortical activity and hemodynamics across arousal states

This study examines how pupil diameter and blinking correlate with cortical activity and hemodynamics across different arousal states in mice, finding strong relationships that can reliably indicate arousal state.

Chemogenetic enhancement of cAMP signaling renders hippocampal synaptic plasticity resilient to the impact of acute sleep deprivation

This study shows that increasing cAMP levels in hippocampal neurons during sleep deprivation prevents deficits in long-term potentiation, indicating cAMP signaling mediates sleep loss effects on synaptic plasticity.

Evaluation of the Efficacy of the Hypocretin/orexin Receptor Agonists TAK-925 and ARN-776 in Narcoleptic Orexin/tTA; TetO-DTA Mice

This study evaluates the efficacy of TAK-925 and ARN-776, HCRTR2 agonists, in reducing cataplexy and promoting wakefulness in narcoleptic mice.

Sleep-related consolidation and generalizability of motor skills learned by physical practice, motor imagery and action observation

This study investigates whether sleep spindle activity supports consolidation of motor skills learned through physical practice, motor imagery, and action observation, finding a common spindle organization but distinct outcomes.

Machine learning approaches to identify sleep genes

This study uses machine learning to predict sleep-related genes from genomic data and validates the NF-κB pathway's role in sleep duration in mice.

Reactivating Positive Personality Traits During Sleep Promotes Positive Self-Referential Processing

The paper shows that combining wakeful training with sleep-based memory reactivation enhances positive self-referential processing.

Do naps benefit novel word learning? Developmental differences and white matter correlates

This study examines the effect of daytime naps on word learning in children and adults, finding naps maintain explicit memory but no lexical integration, with white matter correlates in children.

Electrophysiological Markers of Memory Consolidation in the Human Brain when Memories are Reactivated during Sleep

The paper investigates memory consolidation during sleep by reactivating memories with sounds and measuring electrophysiological responses, finding gamma band activity correlates with memory improvement.

Astrocytic Sleep Homeostasis Model

The paper proposes a mathematical model of astrocytic sleep-awake homeostasis that explains the regulation of sleep pressure and synaptic strength dynamics through feedback control loops.

A marked enhancement of a BLOC-1 gene, pallidin, associated with somnolent mouse models deficient in histamine transmission

The paper identifies pallidin, a BLOC-1 gene, as upregulated in mice lacking histamine and orexin, associated with sleep disorders and altered neurotransmitter systems.

Abnormal brain state distribution and network connectivity in a SYNGAP1 rat model

This study analyzes EEG brain state distribution and connectivity in SYNGAP1 mutant rats, finding altered state dynamics and reduced connectivity during sleep spindles.

The theta paradox: 4-8 Hz EEG oscillations reflect both local sleep and cognitive control

This study examines theta oscillations (4-8 Hz) in EEG during cognitive tasks and sleep deprivation, finding differences in topography but suggesting a common mechanism.

Sleep alterations in a mouse model of Spinocerebellar ataxia type 3

This study quantifies sleep EEG changes in a SCA3 mouse model, finding increased REM duration, beta power, and spectral alterations in homozygous mice compared to wild-type.

Memory loss at sleep onset

The paper shows that N1 sleep leads to more memory forgetting compared to N2 sleep, with alpha/theta power ratio linked to forgetting rates.

Non-rapid eye movement sleep determines resilience to social stress

This study shows that increased non-rapid eye movement (NREM) sleep in the prefrontal cortex is necessary and sufficient for promoting resilience to social stress in mice.

Acute sleep deprivation induces synaptic remodeling at the soleus muscle neuromuscular junction in rats

This study shows that acute sleep deprivation alters neuromuscular junction structure and function in rat soleus muscle, with partial recovery after sleep restoration.

Improving Memory via Automated Targeted Memory Reactivation during Sleep

The paper develops an automated system for Targeted Memory Reactivation during sleep and shows it can improve spatial memory when stimulus intensity is controlled.

Acute hyper- and hypoglycemia uncouples the metabolic cooperation between glucose and lactate to disrupt sleep

This study shows that acute hyper- and hypoglycemia disrupt the metabolic cooperation between glucose and lactate in the brain, affecting sleep-wake cycles.

Spatiotemporal patterns of sleep spindle activity in human anterior thalamus and cortex

The paper analyzes sleep spindle activity in human anterior thalamus and cortex using EEG and DBS recordings, finding coordinated patterns and frequency-dependent topography.

The human thalamus orchestrates neocortical oscillations during NREM sleep.

This study uses intrathalamic recordings to show that different thalamic nuclei coordinate neocortical oscillations during NREM sleep in humans, with distinct timing relationships between thalamic and cortical slow oscillations and spindles.

Scream's roughness confers a privileged access to the brain during sleep

This study shows that roughness in screams enhances neural processing during sleep and wakefulness, increasing sleep spindle activity and response reliability.

Shank3 influences mammalian sleep development

This study shows that Shank3{Delta}C mice have reduced total sleep, altered REM/NREM sleep dynamics, and impaired sleep latency responses, suggesting sleep abnormalities are a core feature of ASD.

Entrainment to sleep spindles reflects dissociable patterns of connectivity between cortex and basal ganglia

This study investigates how sleep spindles coordinate neural activity between the cortex and basal ganglia in non-human primates, revealing distinct patterns of connectivity in different BG regions.