Neonatal and fetal brain pathology

Lactate receptor HCAR1 regulates neurogenesis and microglia activation after neonatal hypoxia-ischemia

This study shows that HCAR1 promotes tissue regeneration after neonatal hypoxia-ischemia by regulating neural progenitor cell proliferation and microglia activation.

A unique cerebellar pattern of microglia activation in a mousemodel of encephalopathy of prematurity

This study investigates the effects of perinatal inflammation on cerebellar development in a mouse model of encephalopathy of prematurity, finding unique microglia activation and type I interferon signaling dysregulation in the cerebellum.

Functional recovery from tactile stimulation after perinatal cortical injury is mediated by FGF-2

This study shows that tactile stimulation and FGF-2 administration after perinatal cortical injury in rats promote functional recovery by altering neuronal morphology and FGF-2 expression.

Establishment of a hypoxia ischemia reperfusion brain damagemodel in neonatal rats

This study establishes a new neonatal rat model for hypoxia ischemia reperfusion brain damage by using a CCA muscle bridge method, showing effective ischemia reperfusion and brain damage.

An exploratory study of EEG connectivity during the first year of life in preterm and full-term infants

This study compares EEG connectivity in full-term and preterm infants during their first year, finding age-related trends and differences between groups.

Brain age predicted using graph convolutional neural network explains developmental trajectory in preterm neonates

This paper uses a graph convolutional neural network to predict brain age in preterm neonates, showing it outperforms other methods and links brain age to future neurodevelopmental outcomes.

Moderately Inducing Autophagy Reduces Tertiary Brain Injury After Perinatal Hypoxia-Ischemia

The paper shows that inducing autophagy after perinatal hypoxia-ischemia reduces cell death and improves neurological outcomes in rats.

The neuroprotective effects of Sonic hedgehog pathway agonist SAG in a rat model of neonatal stroke

This study shows that a single dose of SAG, a Shh pathway agonist, reduces brain injury and improves cognitive outcomes in a rat model of neonatal stroke.

Increased Excitability and Heightened Magnitude of Long-term Potentiation at Hippocampal CA3-CA1 Synapses in a Mouse Model of Neonatal Hyperoxia Exposure

This study shows that neonatal hyperoxia exposure in mice leads to heightened CA3-CA1 synaptic function in early adulthood, potentially contributing to hippocampal shrinkage and cognitive deficits.

A physiologically-validated rat model of term birth asphyxia with seizure generation after, not during, brain hypoxia

This paper introduces a rat model of birth asphyxia where seizures occur after, not during, hypoxia, and shows that intermittent hypoxia promotes neuronal hyperexcitability leading to seizures.

Genome-wide postnatal changes in immunity following fetal inflammatory response

The paper identifies molecular changes in immunity postnatal in ELGANs with fetal inflammatory response, showing innate immune activation and adaptive immunity impairment.

MicroRNA-9 Mediated the Protective Effect of Ferulic Acid on Hypoxic-Ischemic Brain Injury in Neonatal Rats

This study shows that ferulic acid protects against hypoxic-ischemic brain injury in neonatal rats by inhibiting miRNA-9 expression, which restores BDNF levels and reduces neuronal damage.

Transient uterine hypercontractility causes fetal cerebral oxidative stress and enduring mitochondrial and behavioral abnormalities in adolescent male rat offspring

This study shows that transient placental ischemia-hypoxemia in pregnant rats causes oxidative stress and long-term mitochondrial and behavioral issues in male offspring.

Altered motoneuron properties contribute to motor deficits in a rabbit hypoxia ischemia model of cerebral palsy

This study investigates how altered spinal motoneuron properties contribute to motor deficits in a rabbit hypoxia-ischemia model of cerebral palsy, finding significant physiological differences between affected and unaffected groups.

Endogenous responses in brain pH and PO2 in a rodent model of birth asphyxia

The paper investigates brain pH and PO2 changes in a rodent asphyxia model, finding that hypercapnia restores brain PO2 and protects against acidosis, unlike hypoxia.

Intravenous edaravone plus therapeutic hypothermia offers limited neuroprotection in the hypoxic-ischaemic newborn piglet

This study evaluates the neuroprotective effects of edaravone combined with therapeutic hypothermia in newborn piglets after hypoxic-ischaemic injury, finding no significant improvement over hypothermia alone.

The effects of carnosine pretreatment on the inflammatory response and the PI3K/Akt signaling pathway following hypoxia-ischemia in neonatal rats

This study investigates the effects of carnosine pretreatment on inflammation and the PI3K/Akt pathway in neonatal rats after hypoxia-ischemia, finding reduced inflammation and increased Akt activation.

Human Umbilical Cord blood monocytes, but not adult blood monocytes, rescue brain cells from hypoxic-ischemic injury: Mechanistic and therapeutic implications

The paper shows that cord blood monocytes, not adult blood monocytes, protect brain cells from hypoxic-ischemic injury through secreted factors, with CD14+ monocytes being critical.

Network based statistics reveals trophic and neuroprotective effect of early high dose erythropoetin on brain connectivity in very preterm infants

This study uses connectomic analysis to show that early high-dose EPO in preterm infants strengthens brain connectivity, particularly in frontal and temporal lobes, and increases network segregation.

Chorioamnionitis Is a Risk Factor for Intraventricular Hemorrhage in Preterm Infants: A Systematic Review and Meta-Analysis

This paper conducts a systematic review and meta-analysis showing chorioamnionitis is a risk factor for intraventricular hemorrhage in preterm infants, but not directly linked to prematurity severity.

Disruption to functional networks in neonates with perinatal brain injury predicts motor skills at 8 months

The paper uses fcMRI to predict motor impairment in neonates with perinatal brain injury by analyzing disruption in functional brain networks.

The Effect Of Perinatal Brain Injury On Dopaminergic Function And Hippocampal Volume In Adult Life

This study finds that perinatal brain injury in very preterm humans is linked to reduced dopamine synthesis and hippocampal volume in adulthood.

Integrative genomics study of microglial transcriptome reveals effect of DLG4 (PSD95) on white matter in preterm infants.

This paper identifies DLG4 (PSD95) expression in microglia and links genetic variation in DLG4 to white matter structure in preterm infants.